In vivo transdermal delivery of diclofenac by ion-exchange iontophoresis with geraniol

• 資料種別: 記事
• タイトル: In vivo transdermal delivery of diclofenac by ion-exchange iontophoresis with geraniol
• 著者・編者: Kaoru Kigasawa; Kazuaki Kajimoto; Misuzu Watanabe 他
• 著者標目: Kaoru Kigasawa; Kazuaki Kajimoto; Misuzu Watanabe
• タイトル（掲載誌）: Biological and pharmaceutical bulletin
• 巻号年月日等（掲載誌）: 32(4) 2009.4
• 掲載巻: 32
• 掲載号: 4
• 掲載ページ: 684～687
• 掲載年月日（W3CDTF）: 2009-04
• ISSN（掲載誌）: 0918-6158
• ISSN-L（掲載誌）: 0918-6158
• 出版事項（掲載誌）: Tokyo : Pharmaceutical Society of Japan
• 出版地（国名コード）: JP
• 本文の言語コード: eng
• 件名標目: iontophoresis; transdermal drug delivery; diclofenac sodium; geraniol; anti-inflammatory drug
• NDLC: ZS51
• 対象利用者: 一般
• 所蔵機関: 国立国会図書館
• 請求記号: Z53-V41
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館雑誌記事索引; https://ndlsearch.ndl.go.jp
• 書誌ID（NDLBibID）: 10194358; http://id.ndl.go.jp/bib/10194358
• 整理区分コード: 632

• 要約等: A novel iontophoretic system utilizing ion-exchange membranes is effective for selective transdermal delivery of ionized drugs. In the present study, we examined <i>in vivo</i> availability and safety of ion-exchange iontophoresis in the transdermal delivery of anionic diclofenac, a well known anti-inflammatory medication, to rat dorsal skin. While iontophoresis increased the plasma concentration of diclofenac sodium and skin injury was not observed, no anti-inflammatory effect was exerted. To enhance the efficiency of transdermal delivery of diclofenac sodium, iontophoresis was combined with topical application of one of three terpenes (menthol, nerolidol or geraniol) as chemical enhancers. By combining iontophoresis with geraniol, the plasma concentration of diclofenac sodium increased over 20-fold, and suppression of inflammation was achieved. Skin irritation was not seen even after 1.5 h iontophoresis. The enhancing effect of geraniol is attributed to increased penetration of the drug into the stratum corneum as well as enhanced transport across the anion-exchange membrane. Ion-exchange iontophoresis combined with geraniol is a highly effective transdermal delivery system.
• DOI: 10.1248/bpb.32.684
• オンライン閲覧公開範囲: インターネット公開
• 連携機関・データベース: 科学技術振興機構 : J-STAGE; http://www.jstage.jst.go.jp

• 要約等: A novel iontophoretic system utilizing ion-exchange membranes is effective for selective transdermal delivery of ionized drugs. In the present study, we examined <i>in vivo</i> availability and safety of ion-exchange iontophoresis in the transdermal delivery of anionic diclofenac, a well known anti-inflammatory medication, to rat dorsal skin. While iontophoresis increased the plasma concentration of diclofenac sodium and skin injury was not observed, no anti-inflammatory effect was exerted. To enhance the efficiency of transdermal delivery of diclofenac sodium, iontophoresis was combined with topical application of one of three terpenes (menthol, nerolidol or geraniol) as chemical enhancers. By combining iontophoresis with geraniol, the plasma concentration of diclofenac sodium increased over 20-fold, and suppression of inflammation was achieved. Skin irritation was not seen even after 1.5 h iontophoresis. The enhancing effect of geraniol is attributed to increased penetration of the drug into the stratum corneum as well as enhanced transport across the anion-exchange membrane. Ion-exchange iontophoresis combined with geraniol is a highly effective transdermal delivery system.
• DOI: 10.1248/bpb.32.684; https://doi.org/10.1248/bpb.32.684
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（URI）: http://id.ndl.go.jp/bib/10194358; https://ndlsearch.ndl.go.jp/books/R000000004-I10194358; http://www.jstage.jst.go.jp/article/bpb/32/4/32_4_684/_pdf; https://search.jamas.or.jp/link/ui/2009266117
• 参照: Noninvasive and per-sistence transfollicular drug delivery system using a combination of liposome and iontophoresis; https://cir.nii.ac.jp/crid/1050306506458942848; Electric Stimulus Opens Intercellular Spaces in Skin; https://cir.nii.ac.jp/crid/1360848658910754176; 電位勾配を用いた経皮投与の基礎理論と応用; https://cir.nii.ac.jp/crid/1390282679251175424
• 参照: Enhanced skin permeation of diclofenac by iontophoresis: in vitro and in vivo studies; https://cir.nii.ac.jp/crid/1360574094662666240; Characterization of the Permselective Properties of Excised Human Skin During Iontophoresis; https://cir.nii.ac.jp/crid/1360855569019717376; lontophoretic Devices for Drug Delivery; https://cir.nii.ac.jp/crid/1360855571126591616; A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION; https://cir.nii.ac.jp/crid/1361137044247851392; The effects of electric current applied to skin: A review for transdermal drug delivery; https://cir.nii.ac.jp/crid/1361137044685830272; The effect of iontophoresis and vehicle pH on the in-vitro permeation of lignocaine through human stratum corneum; https://cir.nii.ac.jp/crid/1361137046203557376; Enhancing effect of terpenes on the in vitro percutaneous absorption of diclofenac sodium; https://cir.nii.ac.jp/crid/1361418521092069632; A Review of Selected Investigational Nonsteroidal Antiinflammatory Drugs of the 1980s; https://cir.nii.ac.jp/crid/1361699993393142656; Clinical Pharmacokinetics of Diclofenac; https://cir.nii.ac.jp/crid/1361699994204818432; Iontophoresis: Applications in Transdermal Medication Delivery; https://cir.nii.ac.jp/crid/1361699994779969408; The effect of terpene concentrations on the skin penetration of diclofenac sodium; https://cir.nii.ac.jp/crid/1362262945093837824; Comparison of Depolarizing and Direct Current Systems on Iontophoretic Enhancement of Transport of Sodium Benzoate Through Human and Hairless Rat Skin; https://cir.nii.ac.jp/crid/1362262945129792256; Iontophoretic Delivery Model Inorganic and Drug Ions; https://cir.nii.ac.jp/crid/1362262945448222208; Iontophoretic Delivery of Nonpeptide Drugs: Formulation Optimization for Maximum Skin Permeability; https://cir.nii.ac.jp/crid/1362825894014625792; Terpenes and the Lipid–Protein–Partitioning Theory of Skin Penetration Enhancement; https://cir.nii.ac.jp/crid/1362825894409055488; Transdermal iontophoresis of insulin; https://cir.nii.ac.jp/crid/1363670319368028032; Iontophoretic Drug Delivery: Effects of Physicochemical Factors on the Skin Uptake of Nonpeptide Drugs; https://cir.nii.ac.jp/crid/1363670320575936768; Influence of Electrical and Chemical Factors on Transdermal Iontophoretic Delivery of Three Diclofenac Salts.; https://cir.nii.ac.jp/crid/1390001204626324224; Effect of lipophilicity on in vivo iontophoretic delivery; https://cir.nii.ac.jp/crid/1390282679603139456
• 連携機関・データベース: 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/
• 提供元機関・データベース: Japan Link Center; https://japanlinkcenter.org/top; 雑誌記事索引データベース; https://ndlsearch.ndl.go.jp; Crossref; https://www.crossref.org; CiNii Articles
• 書誌ID（NDLBibID）: 10194358; http://id.ndl.go.jp/bib/10194358
• NII論文ID: 110007160679