複合体医薬品の性状に関する研究-1-アミノフィリンの示差熱天秤分析
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- 資料種別
- 記事
- 著者・編者
- 西庄 重次郎竹中 富美子
- タイトル（掲載誌）
- 薬学雑誌 = Journal of the Pharmaceutical Society of Japan / 日本薬学会 編
- 巻号年月日等（掲載誌）
- 99(8) 1979.08
- 掲載巻
- 99
- 掲載号
- 8
- 掲載ページ
- p824～829
- 掲載年月日（W3CDTF）
- 1979-08
- ISSN（掲載誌）
- 0031-6903
- ISSN-L（掲載誌）
- 0031-6903
- 出版事項（掲載誌）
- 東京 : 日本薬学会
- 出版地（国名コード）
- JP
- 本文の言語コード
- jpn
- NDLC
- 対象利用者
- 一般
- 記事種別、記事分類
- 記事分類: 薬学
- 所蔵機関
- 国立国会図書館
- 請求記号
- Z19-411
- 連携機関・データベース
- 国立国会図書館 : 国立国会図書館雑誌記事索引
- 書誌ID（NDLBibID）
- 2093961
- 整理区分コード
- 632
- 要約等
- Liberation of ethylenediamine and crystal water from aminophylline JP was examined by differential thermal balance and X-ray diffraction methods. Differential thermal balance analysis of aminophylline, carried out in air, at the temperature elevation rate of 2.5°/min, showed that loss in weight started at around 67°, accompanied with endothermic peak which transited to a small endothermic peak, and the thermal change ended at around 130°when weight loss was completed. The thermal balance curve also showed changes corresponding to the two endothermic peaks. Samples were collected at various decomposition rates for analysis and it was found that there may be two routes of decomposition ; one in which aminophylline would lose ethylenediamine and crystal water and convert directly into anhydrous theophylline, and the other in which it loses a part of crystal water to change into aminophylline with about one-half molecule of crystal water (tentatively termed α-aminophylline) and then change into anhydrous theophylline. It was considered that the first endothermic peak corresponds to the overlapping of the process of conversion of aminophylline directly into anhydrous theophylline and the process of aminophylline changing into α-aminophylline, and the second endothermic peak corresponds to the process of liberation of ethylenediamine and crystal water from α-aminophylline.
- DOI
- 10.1248/yakushi1947.99.8_824
- オンライン閲覧公開範囲
- インターネット公開
- 連携機関・データベース
- 科学技術振興機構 : J-STAGE
- 要約等
- Liberation of ethylenediamine and crystal water from aminophylline JP was examined by differential thermal balance and X-ray diffraction methods. Differential thermal balance analysis of aminophylline, carried out in air, at the temperature elevation rate of 2.5°/min, showed that loss in weight started at around 67°, accompanied with endothermic peak which transited to a small endothermic peak, and the thermal change ended at around 130°when weight loss was completed. The thermal balance curve also showed changes corresponding to the two endothermic peaks. Samples were collected at various decomposition rates for analysis and it was found that there may be two routes of decomposition ; one in which aminophylline would lose ethylenediamine and crystal water and convert directly into anhydrous theophylline, and the other in which it loses a part of crystal water to change into aminophylline with about one-half molecule of crystal water (tentatively termed α-aminophylline) and then change into anhydrous theophylline. It was considered that the first endothermic peak corresponds to the overlapping of the process of conversion of aminophylline directly into anhydrous theophylline and the process of aminophylline changing into α-aminophylline, and the second endothermic peak corresponds to the process of liberation of ethylenediamine and crystal water from α-aminophylline.
- DOI
- 10.1248/yakushi1947.99.8_824
- 関連情報（URI）
- 連携機関・データベース
- 国立情報学研究所 : CiNii Research
- 提供元機関・データベース
- Japan Link Center雑誌記事索引データベースCrossrefCiNii Articles
- 書誌ID（NDLBibID）
- 2093961
- NII論文ID
- 110003653042