外科的閉経を伴う婦人科がんサバイバーの手術前後の生活の質、感情、更年期症状の変化およびホルモン補充療法の有効性についての検討 ：1年間の縦断的観察研究

• 資料種別: 博士論文
• タイトル: 外科的閉経を伴う婦人科がんサバイバーの手術前後の生活の質、感情、更年期症状の変化およびホルモン補充療法の有効性についての検討 ：1年間の縦断的観察研究
• 著者・編者: 唐木田, 智子
• 著者標目: 唐木田, 智子
• 出版事項: MDPI
• 並列タイトル等: Changes in quality of life, depression, and menopausal symptoms after surgical menopause and the efficacy of hormone replacement therapy in gynecological cancer survivors: A one-year prospective longitudinal study
• 授与機関名: 鹿児島大学
• 授与年月日: 2025-11-12
• 報告番号: 甲総研第809号
• 学位: 博士(医学)
• 本文の言語コード: eng
• 件名標目: gynecological cancer survivors; quality of life; surgical menopause; menopausal symptoms; depression; hormone replacement therapy
• 対象利用者: 一般
• 一般注記: 出版タイプ： VoR; 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨; Background and Objectives: This study investigated changes in quality of life (QOL), depression, and menopausal symptoms after surgical menopause, and the efficacy of hormone replacement therapy (HRT) in gynecological cancer survivors (GCS). Materials and Methods: Participants undergoing gynecologic cancer surgery (N = 155) were divided into those who received HRT after surgical menopause (SH, N = 47), those after surgical menopause (SM, N = 54), and those after natural menopause (NM, N = 54). QOL, depression, and menopausal symptoms were assessed using the Functional Assessment of Cancer Therapy-General (FACT-G), Center for Epidemiologic Studies Depression Scale (CES-D), and Endocrine Symptoms Subscale-19 (ESS-19), respectively. Assessments were conducted before and at 6 and 12 months after surgery. Results: In SH and SM, FACT-G and CES-D were worst before surgery, gradually improved by 6 months, and remained stable for the following 6 months. FACT-G and CES-D showed an inverse relationship. ESS-19 did not change in SH and SM for 12 months. Among the items on the ESS-19, worsened vasomotor symptoms (VMSs), assessed with ES1, showed more improvement in SH than in SM, while worsened arthralgia assessed with BRM1 was maintained in SM. Multivariate analysis showed that HRT was not independently correlated with changes in QOL and depression status. Conclusions: In GCS, the prevalence of depression was highest at cancer disclosure along with declining QOL. QOL gradually improved by 6 months after surgery in SH and SM, but not in NM. Although menopausal HRT is known to alleviate VMS, anxiety, and depression, its efficacy for cancer-related emotional distress and the associated decline in QOL seems limited.; Noriko Karakida, Shintaro Yanazume, Natsuko Uchida, Mika Sakihama, Tsutomu Douchi and Hiroaki Kobayashi Changes in Quality of Life, Depression, and Menopausal Symptoms After Surgical Menopause and the Efficacy of Hormone Replacement Therapy in Gynecological Cancer Survivors: A One-Year Prospective Longitudinal Study Medicina 2025, 61(7), 1191 https://doi.org/10.3390/medicina61071191
• 記録形式（IMT）: application/pdf
• 一次資料へのリンクURL: Diss_karakida_noriko_ISK809_2025.pdf （fulltext）; https://ir.kagoshima-u.ac.jp/record/2001901/files/Diss_karakida_noriko_ISK809_2025.pdf
• オンライン閲覧公開範囲: インターネット公開
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 鹿児島大学 : 鹿児島大学リポジトリ