The suppressive effect of immune stress on LH secretion is absent in the early neonatal period in rats

• 資料種別: 博士論文
• ISSN: 0736-5748
• タイトル: The suppressive effect of immune stress on LH secretion is absent in the early neonatal period in rats
• 巻次・部編番号: 46
• 著者・編者: Munkhzaya, Munkhsaikhan; Matsuzaki, Toshiya; Iwasa, Takeshi; Tungalagsuvd, Altankhuu; Kawami, Takako; Kato, Takeshi; Kuwahara, Akira; Irahara, Minoru
• 著者標目: Munkhzaya, Munkhsaikhan; Matsuzaki, Toshiya; Iwasa, Takeshi; Tungalagsuvd, Altankhuu; Kawami, Takako; Kato, Takeshi; Kuwahara, Akira; Irahara, Minoru
• 出版事項: Elsevier|International Society for Developmental Neuroscience
• 出版年月日等: 2015-07-15
• 出版年（W3CDTF）: 2015-07-15
• 並列タイトル等: 生後早期のラットでは免疫ストレスによるLH分泌抑制反応が確立されていない
• タイトル（掲載誌）: International Journal of Developmental Neuroscience
• 授与機関名: 徳島大学
• 授与年月日: 2017-03-23
• 授与年月日（W3CDTF）: 2017-03-23
• 報告番号: 甲第3023号
• 学位: 博士（医学）
• 博論授与番号: 甲第3023号
• 本文の言語コード: eng
• 件名標目: LPS; Cytokines; Stress; Hyporesponsive period; HPG axis; LH
• 対象利用者: 一般
• 一般注記: Some physiological functions display weak responses to stress in the early neonatal period; i.e., theyexhibit stress hyporesponse periods. In this study, we evaluated whether gonadotropin regulatory fac-tors exhibit stress hyporesponsive periods in male and female rats. Rats were intraperitoneally injectedwith lipopolysaccharide (100 μg/kg) (LPS group) or saline (control group) on postnatal day (PND) 5,10, 15, or 25. Then, their serum luteinizing hormone (LH) concentrations and hypothalamic mRNAlevels of gonadotropin regulatory factors; i.e., kisspeptin (Kiss1), the kisspeptin receptor (Kiss1r), andgonadotropin-releasing hormone (GnRH), were measured at 2 h after the injection. The hypothalamicmRNA levels of pro-inflammatory cytokines were also measured because they suppress gonadotropinsecretion. The serum LH concentration of the LPS group was lower than that of the control group atPND25 in both sexes, but no such difference was seen at PND5, 10, or 15 in either sex. In both sexes,the hypothalamic tumor necrosis factor (TNF)α and interleukin (IL)-6 mRNA expression levels of the LPSgroup were higher than those of the control group at PND25, but not at PND5 or 10. The hypothalamicIL-1β mRNA expression level of the LPS group was higher than that of the control group at all time points. The hypothalamic Kiss1, Kiss1r, and GnRH mRNA expression levels of the LPS and control groups did notdiffer at any time point in either sex. These findings suggest that gonadotropin regulatory factors exhibitstress hyporesponse periods. The hypothalamic–pituitary–gonadal axis (HPG) might become responsiveto immune stress between PND15 and 25, which could be related to enhanced hypothalamic cytokineexpression. The avoidance of infectious stress during the early neonatal period might be important fornormal development of the HPG axis.
• DOI: info:doi/10.1016/j.ijdevneu.2015.06.007; https://doi.org/info:doi/10.1016/j.ijdevneu.2015.06.007
• 国立国会図書館永続的識別子: info:ndljp/pid/10951839; https://dl.ndl.go.jp/pid/10951839
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2017-09-02T15:28:24+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://repo.lib.tokushima-u.ac.jp/110115
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp