並列タイトル等血漿レニン活性値は、急性心筋梗塞患者の独立した予後予測因子である
一般注記type:Thesis
Background: Plasma renin activity (PRA) is associated with cardiovascular events in patients with heart failure (HF), but its prognostic role in acute myocardial infarction (AMI) is unclear. Methods and Results: A total of 878 patients with information on baseline PRA on admission were selected from 1,055 AMI patients who underwent emergency coronary angiography between 2007 and 2016. The patients were divided into 2 groups according to their median PRA (2.0 ng/mL/h). The primary endpoint was major adverse cardiac events (MACE), defined as a composite of cardiovascular death and hospitalization because of HF. During follow-up (median 4.5±3.1 years), MACE occurred in 108 patients. Kaplan-Meier analysis showed that the high PRA group had significantly lower MACE-free survival than the low PRA group (log-rank P=0.0009). By multivariate analysis, high PRA was an independent predictor of MACE (hazard ratio (HR) 1.573; 95% confidence interval (CI) 1.049–2.396, P=0.0282). Similarly, among 580 patients who had not been previously treated with renin-angiotensin system inhibitors or β-blockers on admission, high PRA was an independent predictor of MACE (HR 1.732; 95% CI 1.010–3.047, P=0.0460). Conclusions: In the studied AMI patients, elevated levels of PRA were independently associated with poor prognosis.
博士（医学）・甲第745号・令和2年6月30日
日本循環器学会の許諾を得て登録（2020年10月19日付）
ジャーナル公式サイト（日本循環器学会HP内）：https://www.j-circ.or.jp/journal/
公開サイト（J-STAGE）：https://www.jstage.jst.go.jp/browse/circj/
identifier:Circulation journal Vol.83 No.6 p.1324-1329 (2019 May)
identifier:13469843
identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3752
identifier:Circulation journal, 83(6): 1324-1329
DOIinfo:doi/10.1253/circj.CJ-18-1195
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