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博士論文
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DOI[10.24561/00019580]のデータに遷移します
Topographic Map of Serotonin system : a foundation study for investigating pathophysiology of Autism Spectrum Disorder
- 国立国会図書館永続的識別子
- info:ndljp/pid/12313435
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- type:textIt is well established that serotonergic fibers distribute throughout the brain. Abnormal densities or patterns of serotonergic fibers have b...
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デジタル
- 資料種別
- 博士論文
- 著者・編者
- JANAK, RAJ AWASTHI
- 出版事項
- 出版年月日等
- 2021
- 出版年(W3CDTF)
- 2021
- 並列タイトル等
- 自閉症の病態生理の理解にむけたセロトニン繊維走行の解明
- タイトル(掲載誌)
- 博士論文(埼玉大学大学院理工学研究科(博士後期課程))
- 授与機関名
- 埼玉大学
- 授与年月日
- 2021-03-25
- 授与年月日(W3CDTF)
- 2021-03-25
- 報告番号
- 乙第261号
- 学位
- 博士(学術)
- 博論授与番号
- 乙第261号
- 本文の言語コード
- eng
- 対象利用者
- 一般
- 一般注記
- type:textIt is well established that serotonergic fibers distribute throughout the brain. Abnormal densities or patterns of serotonergic fibers have been implicated in neuropsychiatric disorders. Although many classical studies have examined the distribution pattern of serotonergic fibers, most of them were either limited to specific brain areas or had limitations in demonstrating the fine axonal morphology. In this study, we utilize transgenic mice expressing GFP under the serotonin transporter (SERT) promoter to map the topography of serotonergic fibers across the rostro-caudal extent of each brain area. We demonstrate previously unreported regional density and fine-grained anatomy of serotonergic fibers. Our findings include: 1) SERT fibers distribute abundantly in the thalamic nuclei close to the midline and dorsolateral areas, in most of the hypothalamic nuclei with few exceptions such as the median eminence and arcuate nuclei, and within the basal amygdaloid complex and lateral septal nuclei, 2) the source fibers of innervation of the hippocampus traverse through the septal nuclei before reaching its destination, 3) unique, filamentous type of straight terminal fibers within the nucleus accumbens, 4) laminar pattern of innervation in the hippocampus, olfactory bulb and cortex with heterogenicity in innervation density among the layers, 5) cortical labelling density gradually decreases rostro-caudally, 6) fibers traverse and distribute mostly within the gray matter, leaving the white fiber bundles uninnervated, and 7) most of the highly labelled nuclei and cortical areas have predominant anatomical connection to limbic structures. Although the precise role of serotonergic projections in all of these nuclei are yet to be fully determined, we discuss their possible functional relevance. In conclusion, we provide novel, regionally specific insights on the distribution map of serotonergic fibers using transgenic mouse.ACKNOWLEDGEMENTS ................................................................................................................................... 01. INTRODUCTION...................................................................................................................................... 42. REVIEW OF LITERATURES ....................................................................................................................... 4 2.1. HISTORY OF SEROTONIN MAPPING .......................................................................................................... 4 2.2. BIOCHEMISTRY OF SEROTONIN ............................................................................................................... 7 2.3. DIVERSITY OF SEROTONERGIC NEURONS ................................................................................................... 8 2.4. DEVELOPMENT OF 5-HT RAPHE NEURONS AND THEIR PROJECTIONS ................................................................ 9 2.5. PROJECTIONS OF RAPHE NEURONS ........................................................................................................ 10 2.6. SEROTONIN TRANSPORTER: FUNCTIONAL AND CLINICAL IMPLICATIONS ........................................................... 12 COMPREHENSIVE TOPOGRAPHIC MAP OF THE SEROTONERGIC FIBERS IN THE MOUSE BRAIN ..................... 15 ABSTRACT .................................................................................................................................................... 151. INTRODUCTION.................................................................................................................................... 162. MATERIAL AND METHODS ................................................................................................................... 17 2.1. ANIMALS ....................................................................................................................................... 17 2.2. IMMUNOHISTOCHEMISTRY ................................................................................................................. 17 2.3. IMAGES ACQUISITION AND ANALYSIS ..................................................................................................... 18 3. RESULTS ............................................................................................................................................... 18 3.1. ASCENDING 5-HT PATHWAY AND SUB-PATHWAYS IN THE ADULT BRAIN.......................................................... 19 3.1.1. SUPPLEMENTARY ASCENDING FIBER BUNDLE ....................................................................................... 20 3.2. RAPHE SYSTEM ................................................................................................................................ 20 3.3. INNERVATION PATTERN IN THE THALAMUS ............................................................................................. 22 3.3.1. MIDLINE NUCLEI .......................................................................................................................... 22 3.3.2. INTRALAMINAR NUCLEI.................................................................................................................. 22 3.3.3. ASSOCIATION NUCLEI .................................................................................................................... 23 3.3.4. PRINCIPAL NUCLEI ........................................................................................................................ 23 3.3.5. MEDIAL AND LATERAL HABENULA (EPITHALAMUS) ................................................................................ 24 3.3.6. RETICULAR NUCLEUS..................................................................................................................... 24 3.3.7. OTHER AREAS ............................................................................................................................. 24 3.4. INNERVATION PATTERN IN THE HYPOTHALAMUS ...................................................................................... 24 3.4.1. PREOPTIC REGION ........................................................................................................................ 25 3.4.2. SUPRAOPTIC REGION .................................................................................................................... 25 3.4.3. TUBERAL REGION ......................................................................................................................... 26 3.4.4. MAMILLARY REGION ..................................................................................................................... 26 3.4.5. OTHER AREAS WITHIN THE HYPOTHALAMIC ZONE ................................................................................. 27 3.5. INNERVATION PATTERN IN THE AMYGDALA ............................................................................................. 27 3.5.1. DEEP OR BASOLATERAL GROUP ........................................................................................................ 28 3.5.2. SUPERFICIAL OR CORTICAL-LIKE GROUP .............................................................................................. 28 3.5.3. CENTROMEDIAL GROUP ................................................................................................................. 28 3.5.4. OTHER NUCLEI ............................................................................................................................ 29 3.6. INNERVATION PATTERN IN THE SEPTUM ................................................................................................. 29 3.6.1. THE NUCLEUS OF DIAGONAL BAND (NBD) AND MEDIAL SEPTUM (MS) ...................................................... 29 3.6.2. LATERAL SEPTAL NUCLEUS .............................................................................................................. 30 3.6.3. OTHER SEPTAL AREAS ................................................................................................................... 31 3.7. INNERVATION PATTERN IN THE BASAL GANGLIA ....................................................................................... 31 3.8. INNERVATION PATTERN IN THE NUCLEUS ACCUMBENS .............................................................................. 32 3.9. INNERVATION PATTERN IN THE BED NUCLEUS OF STRIA TERMINALIS ............................................................. 32 3.10. INNERVATION PATTERN IN THE HIPPOCAMPUS......................................................................................... 32 3.11. INNERVATION PATTERN IN THE CORTEX ................................................................................................. 33 3.11.1. PREFRONTAL CORTEX ................................................................................................................... 34 3.11.2. RETROSPLENIAL CORTEX ................................................................................................................ 34 3.11.3. MOTOR CORTEX .......................................................................................................................... 35 3.11.4. SOMATOSENSORY CORTEX ............................................................................................................. 35 3.11.5. AUDITORY AND VISUAL CORTEXES .................................................................................................... 35 3.11.6. RHINAL AREA ............................................................................................................................. 36 3.11.7. PIRIFORM CORTEX........................................................................................................................ 36 3.12. INNERVATION PATTERN IN THE OLFACTORY TUBERCLE AND OLFACTORY BULB ................................................. 36 3.13. INNERVATION PATTERN IN THE CEREBELLUM ........................................................................................... 374. DISCUSSION ......................................................................................................................................... 37 4.1. THALAMUS ..................................................................................................................................... 39 4.2. HYPOTHALAMUS .............................................................................................................................. 40 4.3. AMYGDALA..................................................................................................................................... 42 4.4. BASAL GANGLIA ............................................................................................................................... 43 4.5. CORTEX ......................................................................................................................................... 445. CONCLUSION ....................................................................................................................................... 45DEVELOPMENT OF SEROTONERGIC PROJECTIONS TO SUPRACHIASMATIC NUCLEUS IN THE MOUSE BRAIN . 64ABSTRACT ..................................................................................................................................................... 641. INTRODUCTION.................................................................................................................................... 652. MATERIALS AND METHOD ................................................................................................................... 66 2.1. ANIMALS ....................................................................................................................................... 66 2.2. IMMUNOHISTOCHEMISTRY ................................................................................................................. 66 2.3. IMAGES ACQUISITION AND ANALYSIS ..................................................................................................... 663. RESULTS ............................................................................................................................................... 674. DISCUSSION ......................................................................................................................................... 685. CONCLUSION ....................................................................................................................................... 69SCOPE OF THE STUDY .................................................................................................................................... 70REFERENCES .................................................................................................................................................. 73指導教員 : SHIMOGORI Tomomi
- DOI
- 10.24561/00019580
- 国立国会図書館永続的識別子
- info:ndljp/pid/12313435
- コレクション(共通)
- コレクション(障害者向け資料:レベル1)
- コレクション(個別)
- 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
- 収集根拠
- 博士論文(自動収集)
- 受理日(W3CDTF)
- 2022-08-08T06:02:54+09:00
- 作成日(W3CDTF)
- 2022-06-15
- 記録形式(IMT)
- application/pdf
- オンライン閲覧公開範囲
- 国立国会図書館内限定公開
- デジタル化資料送信
- 図書館・個人送信対象外
- 遠隔複写可否(NDL)
- 可
- 連携機関・データベース
- 国立国会図書館 : 国立国会図書館デジタルコレクション