記事
デジタルデータあり（つくばリポジトリ）
すぐに読む
学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
Application of Proteomic Profiling Based on 2D-DIGE for Classification of Compounds According to the Mechanism of Action
資料詳細
要約等：
- The development of new anticancer agents derived from natural resources requires a rapid identification of their molecular mechanism of action. To mak...
全国の図書館の所蔵
国立国会図書館以外の全国の図書館の所蔵状況を表示します。
所蔵のある図書館から取寄せることが可能かなど、資料の利用方法は、ご自身が利用されるお近くの図書館へご相談ください
書誌情報
この資料の詳細や典拠（同じ主題の資料を指すキーワード、著者名）等を確認できます。
デジタル
- 資料種別
- 記事
- 著者標目
- 出版年月日等
- 2010-05
- 出版年（W3CDTF）
- 2010-05
- タイトル（掲載誌）
- Chemistry & biology
- 巻号年月日等（掲載誌）
- 17 5
- 掲載巻
- 17
- 掲載号
- 5
- 掲載ページ
- 460-470
- 掲載年月日（W3CDTF）
- 2010-05
- ISSN（掲載誌）
- 10745521
- 出版事項（掲載誌）
- Elsevier
- 本文の言語コード
- en
- 件名標目
- 対象利用者
- 一般
- 標準番号（その他）
- PMID : 20534344
- DOI
- 10.1016/j.chembiol.2010.03.016
- オンライン閲覧公開範囲
- インターネット公開
- 著作権情報
- © 2010 Elsevier Ltd
- 関連情報（URI）
- 参照
- Identification of a Molecular Target of a Novel Fungal Metabolite, Pyrrolizilactone, by Phenotypic Profiling SystemsTerpendole E and its Derivative Inhibit STLC‐ and GSK‐1‐Resistant Eg5Methyl 3-((6-Methoxy-1,4-dihydroindeno[1,2-<i>c</i>]pyrazol-3-yl)amino)benzoate (GN39482) as a Tubulin Polymerization Inhibitor Identified by MorphoBase and ChemProteoBase Profiling Methods3β,23,28-Trihydroxy-12-oleanene 3β-Caffeate from <i>Desmodium sambuense</i>-Induced Neurogenesis in PC12 Cells Mediated by ER Stress and BDNF–TrkB Signaling PathwaysDevelopment of a Terpenoid-Production Platform in <i>Streptomyces reveromyceticus</i> SN-593A chemical genomic study identifying diversity in cell migration signaling in cancer cellsAffinity-based target identification for bioactive small moleculesIntegrated profiling methods for identifying the targets of bioactive compounds: MorphoBase and ChemProteoBaseRecent advances in target identification of bioactive natural productsDecomposition Profile Data Analysis for Deep Understanding of Multiple Effects of Natural ProductsDiscovery of small-molecule modulator of heterotrimeric Gi-protein by integrated phenotypic profiling and chemical proteomicsCharacterization of proteome profile data of chemicals based on data-independent acquisition MS with SWATH methodBioenergetic and proteomic profiling to screen small molecule inhibitors that target cancer metabolismsIdentification of a Small-Molecule Inhibitor of DNA Topoisomerase II by Proteomic ProfilingDevelopment of Orthogonal Linear Separation Analysis (OLSA) to Decompose Drug Effects into Basic ComponentsProteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survivalMultidrug Sensitive Yeast Strains, Useful Tools for Chemical Genetics3,6-Epidioxy-1,10-bisaboladiene induces ferroptosis-like cell death through lipid peroxidationTarget identification of small molecules based on chemical biology approachesPhoto-cross-linked small-molecule affinity matrix as a tool for target identification of bioactive small moleculesA novel inhibitor of tumorspheres reveals the activation of the serine biosynthetic pathway upon mitochondrial inhibitionProteomic Profiling for Target Identification of Biologically Active Small Molecules Using 2D DIGEMorphobase, an Encyclopedic Cell Morphology Database, and Its Use for Drug Target IdentificationA small molecule that induces reactive oxygen species via cellular glutathione depletionIdentification of a Small Compound Targeting PKM2-Regulated Signaling Using 2D Gel Electrophoresis-Based Proteome-wide CETSAIdentification of Dihydroorotate Dehydrogenase Inhibitors─Indoluidins─That Inhibit Cancer Cell GrowthTwo-dimensional electrophoresis–cellular thermal shift assay (2DE-CETSA) for target identification of bioactive compoundsProteomic profiling reveals that collismycin A is an iron chelatorFuraquinocins I and J: novel polyketide isoprenoid hybrid compounds from Streptomyces reveromyceticus SN-593Chemical and biological studies of reveromycin AAllantopyrone A activates Keap1–Nrf2 pathway and protects PC12 cells from oxidative stress-induced cell deathTarget Protein Identification on Photocatalyst‐Functionalized Magnetic Affinity BeadsIdentification of a Small-Molecule Glucose Transporter Inhibitor, Glutipyran, That Inhibits Cancer Cell Growth天然物に適したフェノティピックスクリーニングEstablishment of a New Detection System for the Dimerization of IRE1α by BiFC AssayDevelopment of a Novel Platform of Proteome Profiling Based on an Easy-to-Handle and Informative 2D-DIGE SystemInteresting Properties of Profile Data Analysis in the Understanding and Utilization of the Effects of Drugs薬物の包括的な作用理解を実現する作用分離解析の開発
- 参照
- Phoslactomycin targets cysteine‐269 of the protein phosphatase 2A catalytic subunit in cellsActinomycin and DNA transcription.Concanamycin A, the Specific Inhibitor of V-ATPases, Binds to the Vo Subunit cProteomics-based Target IdentificationThe value of natural products to future pharmaceutical discoveryProteasome inhibitors: valuable new tools for cell biologistsIdentifying off-target effects and hidden phenotypes of drugs in human cellsTotal Synthesis of Iejimalide A−D and Assessment of the Remarkable Actin-Depolymerizing Capacity of These Polyene MacrolidesThe Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and DiseaseRole of Nuclear Lamins in Nuclear Organization, Cellular Signaling, and Inherited DiseasesEffects of inhibitors of tubulin polymerization on GTP hydrolysis.Absolute stereochemistry and antitumor activity of iejimalidesInhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kineticsInhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation.Localization of Critical Histidyl Residues Required for Vinblastine-induced Tubulin Polymerization and for Microtubule AssemblyDNA TOPOISOMERASE POISONS AS ANTITUMOR DRUGSCatalytic inhibitors of DNA topoisomerase IIThe Mechanism by which Cycloheximide and Related Glutarimide Antibiotics Inhibit Peptide Synthesis on Reticulocyte RibosomesAntitumor bisdioxopiperazines inhibit yeast DNAtopoisomerase II by trapping the enzyme in the form of a closed proteinclamp.HSP27 favors ubiquitination and proteasomal degradation of p27 <sup>Kip1</sup> and helps S‐phase re‐entry in stressed cellsInhibition of DNA topoisomerase II by ICRF-193 induces polyploidization by uncoupling chromosome dynamics from other cell cycle events.Gene and Protein Expression Profiling of Human Ovarian Cancer Cells Treated with the Heat Shock Protein 90 Inhibitor 17-Allylamino-17-DemethoxygeldanamycinFluorescent two-dimensional difference gel electrophoresis unveils the potential of gel-based proteomicsThe identification of an osteoclastogenesis inhibitor through the inhibition of glyoxalase IDiscovering potent and selective reversible inhibitors of enzymes in complex proteomesPolyproline-Rod Approach to Isolating Protein Targets of Bioactive Small Molecules: Isolation of a New Target of IndomethacinEffects of cytochalasin and phalloidin on actin.Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinasesDaunorubicin and doxorubicin, anthracycline antibiotics, a physicochemical and biological reviewGene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulatorsOpen source clustering softwareAntibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycinEpoxyquinol A, a Highly Functionalized Pentaketide Dimer with Antiangiogenic Activity Isolated from Fungal MetabolitesKinetic Cell-Based Morphological Screening: Prediction of Mechanism of Compound Action and Off-Target EffectsAntitumor Activity of ZSTK474, a New Phosphatidylinositol 3-Kinase InhibitorJasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin.New atpenins, NBRI23477 A and B, inhibit the growth of human prostate cancer cellsA specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).HSP27 Is a Ubiquitin-Binding Protein Involved in I-κBα Proteasomal DegradationUp-regulation of Heat Shock Protein 27 Induces Resistance to 17-Allylamino-Demethoxygeldanamycin through a Glutathione-Mediated MechanismProteomic analysis of pancreatic endocrine tumor cell lines treated with the histone deacetylase inhibitor trichostatin AProteasome inhibition leads to the activation of all members of the heat‐shock‐factor familyJava Treeview—extensible visualization of microarray dataBafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells.Maximising sensitivity for detecting changes in protein expression: Experimental design using minimal CyDyesBrefeldin A: insights into the control of membrane traffic and organelle structure.A Phase I Trial of Twice-Weekly 17-Allylamino-Demethoxy-Geldanamycin in Patients with Advanced CancerInhibition of topoisomerase II by antitumor agents bis(2,6-dioxopiperazine) derivativesDiscovery of a novel antitumor benzolactone enamide class that selectively inhibits mammalian vacuolar-type (H+)-ATPasesTunicamycin, a new antibiotic. I. Isolation and characterization of tunicamycinIejimalides Show Anti-Osteoclast Activity<i>via</i>V-ATPase Inhibition＜ファクトデータベース・フリーウェア特集号＞ 理化学研究所・天然化合物バンク(RIKEN NPDepo)の 化合物データベース"理化学研究所・天然化合物エンサイクロペディア(RIKEN NPEdia)"
- 連携機関・データベース
- 国立情報学研究所 : CiNii Research
- 提供元機関・データベース
- 学術機関リポジトリデータベースCrossrefPubMedCrossrefCrossrefCrossrefCrossrefCrossrefCrossrefCrossrefCrossrefCrossrefCrossrefCrossrefCrossrefCrossrefCrossrefCrossrefCrossrefCrossrefCrossrefCrossrefCrossrefCrossrefCrossrefCrossrefCrossrefCrossrefCrossrefCrossrefCrossrefCrossrefCrossrefCrossrefCrossrefCrossrefCrossrefCrossrefCrossrefCrossrefCrossrefIntegbioデータベースカタログ