記事
Transforming mutations of RAC guanosine triphosphatases in human cancers
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Transforming mutations of RAC guanosine triphosphatases in human cancers
- 資料種別
- 記事
- 著者
- Masahito Kawazuほか
- 出版者
- Proceedings of the National Academy of Sciences
- 出版年
- 2013-02-04
- 資料形態
- デジタル
- 掲載誌名
- Proceedings of the National Academy of Sciences 110 8
- 掲載ページ
- p.3029-3034
資料詳細
要約等：
- <jats:p>Members of the RAS superfamily of small guanosine triphosphatases (GTPases) transition between GDP-bound, inactive and GTP-bound, active state...
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デジタル
- 資料種別
- 記事
- 著者標目
- 出版年月日等
- 2013-02-04
- 出版年（W3CDTF）
- 2013-02-04
- タイトル（掲載誌）
- Proceedings of the National Academy of Sciences
- 巻号年月日等（掲載誌）
- 110 8
- 掲載巻
- 110
- 掲載号
- 8
- 掲載ページ
- 3029-3034
- 掲載年月日（W3CDTF）
- 2013-02-04
- ISSN（掲載誌）
- 00278424
- 出版事項（掲載誌）
- Proceedings of the National Academy of Sciences
- 件名標目
- 対象利用者
- 一般
- 標準番号（その他）
- PMID : 23382236
- DOI
- 10.1073/pnas.1216141110
- 作成日（W3CDTF）
- 2013-02-05
- 参照
- Rho signaling research: history, current status and future directionsRho-family small GTPasee: from highly polarized sensory neurons to cancer cellsPotential of GSPT1 as a novel target for glioblastoma therapyVariegated RHOA mutations in adult T-cell leukemia/lymphomaDOCK1 inhibition suppresses cancer cell invasion and macropinocytosis induced by self-activating Rac1P29S mutationDi-Ras2 Protein Forms a Complex with SmgGDS Protein in Brain Cytosol in Order to Be in a Low Affinity State for Guanine Nucleotides<scp>RAC</scp>1 inhibition as a therapeutic target for gefitinib‐resistant non‐small‐cell lung cancerMutational Landscape and Antiproliferative Functions of ELF Transcription Factors in Human CancerDeletion of Rac1GTPase in the Myeloid Lineage Protects against Inflammation-Mediated Kidney Injury in MiceDevelopment of a versatile HPLC-based method to evaluate the activation status of small GTPasesRegulation of MKL1 via actin cytoskeleton dynamics drives adipocyte differentiationRecurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinomaPLAGL2 regulates actin cytoskeletal architecture and cell migrationCross-Linking Antisense Oligodeoxyribonucleotides with a Photoresponsive α-Chloroaldehyde Moiety for RNA Point MutationsA Novel Rac1-GSPT1 Signaling Pathway Controls Astrogliosis Following Central Nervous System InjuryAntitumor activity and pharmacologic characterization of the depsipeptide analog as a novel histone deacetylase/ phosphatidylinositol 3‐kinase dual inhibitor<b><i>NUP214-RAC1</i></b> and <b><i>RAC1-COL12A1</i></b> Fusion in Complex Variant Translocations Involving Chromosomes 6, 7 and 9 in an Acute Myeloid Leukemia Case with <b><i>DEK-NUP214</i></b><i>De novo ARF3</i> variants cause neurodevelopmental disorder with brain abnormalityPathophysiological Mechanisms in Neurodevelopmental Disorders Caused by Rac GTPases Dysregulation: What’s behind Neuro-RACopathiesLonidamine and domperidone inhibit expansion of transformed cell areas by modulating motility of surrounding nontransformed cellsTargeting Ras-Driven Cancer Cell Survival and Invasion through Selective Inhibition of DOCK1Conformational landscape alternations promote oncogenic activities of Ras-related C3 botulinum toxin substrate 1 as revealed by NMRReal-Time Monitoring of RAS Activity Using In Vitro and In-Cell NMR SpectroscopyDecreased conformational stability in the oncogenic N92I mutant of Ras-related C3 botulinum toxin substrate 11．非小細胞肺癌のドライバー変異
- 参照
- High‐throughput resequencing of target‐captured cDNA in cancer cellsRac signaling in breast cancer: A tale of GEFs and GAPsp21 with a phenylalanine 28—-leucine mutation reacts normally with the GTPase activating protein GAP but nevertheless has transforming properties.Identification of transforming gene in two human sarcoma cell lines as a new member of the ras gene family located on chromosome 1Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane culturesFocus on pancreas cancerGuanosine Triphosphatase Activating Protein (GAP) Interacts with the p21 <i>ras</i> Effector Binding DomainThe cytoplasmic protein GAP is implicated as the target for regulation by the ras gene productFive-Year Follow-up of Patients Receiving Imatinib for Chronic Myeloid LeukemiaEffect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: a retrospective analysisAn essential role for Rac in Ras transformationA novel Cdc42Hs mutant induces cellular transformationCharacterization of a newly derived human sarcoma cell line (HT-1080)The small GTP-binding protein rac regulates growth factor-induced membrane rufflingA Landscape of Driver Mutations in MelanomaRas historyRac Guanosine Triphosphatases Represent Integrating Molecular Therapeutic Targets for BCR-ABL-Induced Myeloproliferative DiseaseThe Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRFActivated N-ras controls the transformed phenotype of HT1080 human fibrosarcoma cellsA transforming gene present in human sarcoma cell linesHuman RAS Superfamily Proteins and Related GTPasesExome sequencing identifies recurrent somatic RAC1 mutations in melanomaSuppression of Rac activity induces apoptosis of human glioma cells but not normal human astrocytesIdentification of the transforming EML4-ALK fusion gene in non-small lung cancer
- 連携機関・データベース
- 国立情報学研究所 : CiNii Research
- 提供元機関・データベース
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