Human genetic and immunological determinants of critical COVID-19 pneumonia

• 資料種別: 記事
• タイトル: Human genetic and immunological determinants of critical COVID-19 pneumonia
• 著者標目: Qian Zhang; Paul Bastard; Adem Karbuz; Adrian Gervais; Ahmad Abou Tayoun; Alessandro Aiuti; Alexandre Belot; Alexandre Bolze; Alexandre Gaudet; Anastasiia Bondarenko; Zhiyong Liu; András N. Spaan; Andrea Guennoun; Andres Augusto Arias; Anna M. Planas; Anna Sediva; Anna Shcherbina; Anna-Lena Neehus; Anne Puel; Antoine Froidure; Antonio Novelli; Aslınur Özkaya Parlakay; Aurora Pujol; Aysun Yahşi; Belgin Gülhan; Benedetta Bigio; Bertrand Boisson; Beth A. Drolet; Carlos Andres Arango Franco; Carlos Flores; Carlos Rodríguez-Gallego; Carolina Prando; Catherine M. Biggs; Charles-Edouard Luyt; Clifton L. Dalgard; Cliona O’Farrelly; Daniela Matuozzo; David Dalmau; David S. Perlin; Davood Mansouri; Diederik van de Beek; Donald C. Vinh; Elena Dominguez-Garrido; Elena W. Y. Hsieh; Emine Hafize Erdeniz; Emmanuelle Jouanguy; Esra Şevketoglu; Estelle Talouarn; Eugenia Quiros-Roldan; Evangelos Andreakos; Eystein Husebye; Fahad Alsohime; Filomeen Haerynck; Giorgio Casari; Giuseppe Novelli; Gökhan Aytekin; Guillaume Morelle; Gulsum Alkan; Gulsum Iclal Bayhan; Hagit Baris Feldman; Helen C. Su; Horst von Bernuth; Igor Resnick; Ingrid Bustos; Isabelle Meyts; Isabelle Migeotte; Ivan Tancevski; Jacinta Bustamante; Jacques Fellay; Jamila El Baghdadi; Javier Martinez-Picado; Jean-Laurent Casanova; Jeremie Rosain; Jeremy Manry; Jie Chen; John Christodoulou; Jonathan Bohlen; José Luis Franco; Juan Li; Juan Manuel Anaya; Julian Rojas; Junqiang Ye; K. M. Furkan Uddin; Kadriye Kart Yasar; Kai Kisand; Keisuke Okamoto; Khalil Chaïbi; Kristina Mironska; László Maródi; Laurent Abel; Laurent Renia; Lazaro Lorenzo; Lennart Hammarström; Lisa F. P. Ng; Lluis Quintana-Murci; Lucia Victoria Erazo; Luigi D. Notarangelo; Luis Felipe Reyes; Luis M. Allende; Luisa Imberti; Majistor Raj Luxman Maglorius Renkilaraj; Marcela Moncada-Velez; Marie Materna; Mark S. Anderson; Marta Gut; Marwa Chbihi; Masato Ogishi; Melike Emiroglu; Mikko R. J. Seppänen; Mohammed J. Uddin; Mohammed Shahrooei; Natalie Alexander; Nevin Hatipoglu; Nico Marr; Nihal Akçay; Oksana Boyarchuk; Ondrej Slaby; Ozge Metin Akcan; Peng Zhang; Pere Soler-Palacín; Peter K. Gregersen; Petter Brodin; Pierre Garçon; Pierre-Emmanuel Morange; Qiang Pan-Hammarström; Qinhua Zhou; Quentin Philippot; Rabih Halwani; Rebeca Perez de Diego; Romain Levy; Rui Yang; Şadiye Kübra Tüter Öz; Saleh Al Muhsen; Saliha Kanık-Yüksek; Sara Espinosa-Padilla; Sathishkumar Ramaswamy; Satoshi Okada; Sefika Elmas Bozdemir; Selma Erol Aytekin; Şemsi Nur Karabela; Sevgi Keles; Sevtap Senoglu; Shen-Ying Zhang; Sotirija Duvlis; Stefan N. Constantinescu; Stephanie Boisson-Dupuis; Stuart E. Turvey; Stuart G. Tangye; Takaki Asano; Tayfun Ozcelik; Tom Le Voyer; Tom Maniatis; Tomohiro Morio; Trine H. Mogensen; Vanessa Sancho-Shimizu; Vivien Beziat; Xavier Solanich; Yenan Bryceson; Yu-Lung Lau; Yuval Itan; Aurélie Cobat
• 出版年月日等: 2022-01-28
• 出版年（W3CDTF）: 2022-01-28
• 寄与者: Howard Hughes Medical Institute; Rockefeller University; St. Giles Foundation; National Institutes of Health (US); National Center for Advancing Translational Sciences (US); George Mason University; National Human Genome Research Institute (US); Yale University; Fisher Center for Alzheimer's Research Foundation; Meyer Foundation; JPB Foundation; Agence Nationale de la Recherche (France); Fondation pour la Recherche Médicale; European Commission; Square Foundation; Ministère de l’Enseignement supérieur et de la Recherche (France); Institut National de la Santé et de la Recherche Médicale (France); Université de Paris; Fondation Bettencourt Schueller; Regione Lazio; National Institute of Allergy and Infectious Diseases (US); Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]; Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN) ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN) ; CHU Pitié-Salpêtrière [AP-HP] ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP] ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU); Génétique Evolutive Humaine - Human Evolutionary Genetics ; Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité); ANR-20-COV6-0001,CRISPR-TARGET-CoV,Cribles CRISPR à l'échelle du génome pour identifier de nouvelles cibles thérapeutiques et inhiber la réplication du SARS-CoV-2(2020); UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie; Özçelik, Tayfun; Zhang, Q; Bastard, P; Karbuz, A; Gervais, A; Tayoun, Aa; Aiuti, A; Belot, A; Bolze, A; Gaudet, A; Bondarenko, A; Spaan, An; Guennoun, A; Arias, Aa; Planas, Am; Sediva, A; Shcherbina, A; Neehus, A-; Puel, A; Froidure, A; Novelli, A; Parlakay, Ao; Pujol, A; Yahsi, A; Gulhan, B; Bigio, B; Boisson, B; Drolet, Ba; Franco, Caa; Flores, C; Rodriguez-Gallego, C; Prando, C; Biggs, Cm; Luyt, C-; Dalgard, Cl; O'Farrelly, C; Matuozzo, D; Dalmau, D; Perlin, D; Mansouri, D; van de Beek, D; Vinh, Dc; Dominguez-Garrido, E; Hsieh, Ewy; Erdeniz, Eh; Jouanguy, E; Sevketoglu, E; Talouarn, E; Quiros-Roldan, E; Andreakos, E; Husebye, E; Alsohime, F; Haerynck, F; Casari, G; Novelli, G; Aytekin, G; Morelle, G; Alkan, G; Bayhan, Gi; Feldman, Hb; Su, Hc; von Bernuth, H; Resnick, I; Bustos, I; Meyts, I; Migeotte, I; Tancevski, I; Bustamantem, J; Fellay, J; El Baghdadi, J; Martinez-Picado, J; Casanova, J-; Rosain, J; Manry, J; Chen, J; Christodoulou, J; Bohlen, J; Franco, Jl; Li, J; Anaya, Jm; Rojas, J; Ye, J; Uddin, Kmf; Yasar, Kk; Kisand, K; Okamoto, K; Chaibi, K; Mironska, K; Marodi, L; Abel, L; Renia, L; Lorenzo, L; Hammarstrom, L; Ng, Lfp; Quintana-Murci, L; Erazo, Lv; Notarangelo, Ld; Reyes, Lf; Allende, Lm; Imberti, L; Renkilaraj, Mrlm
• タイトル（掲載誌）: Nature
• 巻号年月日等（掲載誌）: 603 7902
• 掲載巻: 603
• 掲載号: 7902
• 掲載ページ: 587-598
• 掲載年月日（W3CDTF）: 2022-01-28
• ISSN（掲載誌）: 00280836
• 出版事項（掲載誌）: Springer Science and Business Media LLC
• 件名標目: [SDV]Life Sciences [q-bio]; Critical Illness; Health sciences; 610; COVID-19; Dendritic Cells; Settore MED/03 - GENETICA MEDICA; Toll-Like Receptor 3; Basic medicine; Age Distribution; Toll-Like Receptor 7; Interferon Type I; Humans; Sex Distribution; Autoantibodies; Genome-Wide Association Study
• 対象利用者: 一般
• 標準番号（その他）: PMID : 35090163
• DOI: 10.1038/s41586-022-04447-0; https://doi.org/10.1038/s41586-022-04447-0
• 作成日（W3CDTF）: 2022-01-28
• オンライン閲覧公開範囲: インターネット公開
• 著作権情報: https://www.springer.com/tdm
• 関連情報（URI）: https://www.nature.com/articles/s41586-022-04447-0.pdf; https://www.nature.com/articles/s41586-022-04447-0; http://hdl.handle.net/10261/304301; http://hdl.handle.net/20.500.11768/125855; http://hdl.handle.net/2078.1/263109; http://hdl.handle.net/2078.1/258547; http://hdl.handle.net/11693/111756; http://hdl.handle.net/2108/294680
• 参照: Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs; https://cir.nii.ac.jp/crid/1360017280669962752; Cellular and Molecular Mechanisms of Pathogenic and Protective Immune Responses to SARS-CoV-2 and Implications of COVID-19 Vaccines; https://cir.nii.ac.jp/crid/1360021389818400384; Elevated Myl9 reflects the Myl9-containing microthrombi in SARS-CoV-2–induced lung exudative vasculitis and predicts COVID-19 severity; https://cir.nii.ac.jp/crid/1360298341433148416; The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies; https://cir.nii.ac.jp/crid/1360298757418354432; Decoding the Human Genetic and Immunological Basis of COVID-19 mRNA Vaccine-Induced Myocarditis; https://cir.nii.ac.jp/crid/1360298757442982656; Respiratory viral infections in otherwise healthy humans with inherited IRF7 deficiency; https://cir.nii.ac.jp/crid/1360298757449207040; Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children; https://cir.nii.ac.jp/crid/1360302865536957440; Human <i>STAT1</i> gain of function with chronic mucocutaneous candidiasis: A comprehensive review for strengthening the connection between bedside observations and laboratory research; https://cir.nii.ac.jp/crid/1360302866850063232; Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia; https://cir.nii.ac.jp/crid/1360580229830040320; Dysfunctional Sars-CoV-2-M protein-specific cytotoxic T lymphocytes in patients recovering from severe COVID-19; https://cir.nii.ac.jp/crid/1360580230584468864; Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19; https://cir.nii.ac.jp/crid/1360580232431717248; Neutralizing Type I Interferon Autoantibodies in Japanese Patients with Severe COVID-19; https://cir.nii.ac.jp/crid/1360861705573402496
• 参照: SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonists; https://cir.nii.ac.jp/crid/1880865117677744512; Low morbidity in Danish patients with common variable immunodeficiency disorder infected with severe acute respiratory syndrome coronavirus 2; https://cir.nii.ac.jp/crid/1883680965507114368
• 連携機関・データベース: 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/
• 提供元機関・データベース: Crossref; https://www.crossref.org

• 要約等: SARS-CoV-2 infection is benign in most individuals but, in around 10% of cases, it triggers hypoxaemic COVID-19 pneumonia, which leads to critical ill...