Human mesenchymal stem/stromal cells suppress spinal inflammation in mice with contribution of pituitary adenylate cyclase-activating polypeptide (PACAP)

• 資料種別: 記事
• タイトル: Human mesenchymal stem/stromal cells suppress spinal inflammation in mice with contribution of pituitary adenylate cyclase-activating polypeptide (PACAP)
• 著者標目: Tomomi Tsumuraya; Hirokazu Ohtaki; https://ci.nii.ac.jp/author/DB00435179; Dandan Song; Atsushi Sato; Jun Watanabe; Yutaka Hiraizumi; Tomoya Nakamachi; Zhifang Xu; Kenji Dohi; Hitoshi Hashimoto; Takashi Atsumi; Seiji Shioda
• 出版年月日等: 2015-02-22
• 出版年（W3CDTF）: 2015-02-22
• タイトル（掲載誌）: Journal of Neuroinflammation
• 巻号年月日等（掲載誌）: 12 1
• 掲載巻: 12
• 掲載号: 1
• 掲載ページ: 35-
• 掲載年月日（W3CDTF）: 2015-02-22
• 出版事項（掲載誌）: Springer Science and Business Media LLC
• 件名標目: Lipopolysaccharides; Time Factors; Immunology; Cell- and Tissue-Based Therapy; Mice, Transgenic; Cellular and Molecular Neuroscience; Interferon-gamma; Mice; Cell Movement; Animals; Humans; Spinal Cord Injuries; Cell Line, Transformed; Inflammation; Research; Mesenchymal Stem Cells; Mice, Inbred C57BL; Disease Models, Animal; Neurology; Gene Expression Regulation; Cytokines; Pituitary Adenylate Cyclase-Activating Polypeptide; Locomotion; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I
• 対象利用者: 一般
• 標準番号（その他）: PMID : 25889720
• DOI: 10.1186/s12974-015-0252-5; https://doi.org/10.1186/s12974-015-0252-5
• 作成日（W3CDTF）: 2015-02-21
• オンライン閲覧公開範囲: インターネット公開
• 著作権情報: http://creativecommons.org/licenses/by/4.0
• 関連情報（URI）: http://link.springer.com/content/pdf/10.1186/s12974-015-0252-5.pdf; http://link.springer.com/article/10.1186/s12974-015-0252-5/fulltext.html; http://link.springer.com/content/pdf/10.1186/s12974-015-0252-5; https://link.springer.com/content/pdf/10.1186/s12974-015-0252-5.pdf
• 参照: The enhancement of CCL2 and CCL5 by human bone marrow-derived mesenchymal stem/stromal cells might contribute to inflammatory suppression and axonal extension after spinal cord injury; https://cir.nii.ac.jp/crid/1360005742501962880; Effect of PACAP on Heat Exposure; https://cir.nii.ac.jp/crid/1360298755631571712; PACAP as a neuroprotective factor in ischemic neuronal injuries; https://cir.nii.ac.jp/crid/1360567182379480448; Pituitary adenylate cyclase-activating polypeptide (PACAP) contributes to the proliferation of hematopoietic progenitor cells in murine bone marrow via PACAP-specific receptor; https://cir.nii.ac.jp/crid/1360848658463622656; Intrapancreatic injection of human bone marrow-derived mesenchymal stem/stromal cells alleviates hyperglycemia and modulates the macrophage state in streptozotocin-induced type 1 diabetic mice; https://cir.nii.ac.jp/crid/1360848662546019712
• 参照: Unraveling the ischemic brain transcriptome in a permanent middle cerebral artery occlusion model by DNA microarray analysis; https://cir.nii.ac.jp/crid/1050282677601446272; Administration of TSG-6 improves memory after traumatic brain injury in mice; https://cir.nii.ac.jp/crid/1360002216087732736; Bone marrow stromal cells attenuate sepsis via prostaglandin E2–dependent reprogramming of host macrophages to increase their interleukin-10 production; https://cir.nii.ac.jp/crid/1360011145498055296; How mesenchymal stem cells interact with tissue immune responses; https://cir.nii.ac.jp/crid/1360011145673589248; PACAP Stimulates Functional Recovery after Spinal Cord Injury through Axonal Regeneration; https://cir.nii.ac.jp/crid/1360285706483794304; The anti-inflammatory property of human bone marrow-derived mesenchymal stem/stromal cells is preserved in late-passage cultures; https://cir.nii.ac.jp/crid/1360285707275140352; Intravenous Mesenchymal Stem Cells Improve Survival and Motor Function in Experimental Amyotrophic Lateral Sclerosis; https://cir.nii.ac.jp/crid/1360292619798187776; Interleukin-1 participates in the classical and alternative activation of microglia/macrophages after spinal cord injury; https://cir.nii.ac.jp/crid/1360565168930828288; Synergistic Induction of Pituitary Adenylate Cyclase‐Activating Polypeptide (PACAP) Gene Expression by Nerve Growth Factor and PACAP in PC12 Cells; https://cir.nii.ac.jp/crid/1360574095441156608; Review on the Protective Effects of PACAP in Models of Neurodegenerative Diseases In Vitro and In Vivo; https://cir.nii.ac.jp/crid/1360574096429852288; IL-6 and PACAP Receptor Expression and Localization after Global Brain Ischemia in Mice; https://cir.nii.ac.jp/crid/1360848656437117184; Altered psychomotor behaviors in mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP); https://cir.nii.ac.jp/crid/1360855569826846720; Pituitary adenylyl cyclase-activating polypeptide is an intrinsic regulator of Treg abundance and protects against experimental autoimmune encephalomyelitis; https://cir.nii.ac.jp/crid/1360855569948550272; Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: From Structure to Functions; https://cir.nii.ac.jp/crid/1360866223603861888; Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-κB signaling in resident macrophages; https://cir.nii.ac.jp/crid/1361137044611206400; The bright side of the glial scar in CNS repair; https://cir.nii.ac.jp/crid/1361137046249658240; Steroids and Spinal Cord Injury; https://cir.nii.ac.jp/crid/1361418518567056000; Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) and Its Receptors: Neuroendocrine and Endocrine Interaction; https://cir.nii.ac.jp/crid/1361418520415530240; Mesenchymal stem cells in health and disease; https://cir.nii.ac.jp/crid/1361699994877601536; Alternative Activation of Macrophages: An Immunologic Functional Perspective; https://cir.nii.ac.jp/crid/1361699995199816448; Effects of Combinatorial Treatment with Pituitary Adenylate Cyclase Activating Peptide and Human Mesenchymal Stem Cells on Spinal Cord Tissue Repair; https://cir.nii.ac.jp/crid/1361981468995769216; Impaired nerve regeneration and enhanced neuroinflammatory response in mice lacking pituitary adenylyl cyclase activating peptide; https://cir.nii.ac.jp/crid/1362544420339591680; Alternative activation of macrophages; https://cir.nii.ac.jp/crid/1362544420348104192; Cross‐talk between human mesenchymal stem/progenitor cells (MSCs) and rat hippocampal slices in LPS‐stimulated cocultures: the MSCs are activated to secrete prostaglandin E2; https://cir.nii.ac.jp/crid/1362544421072767744; Expression of the receptor for pituitary adenylate cyclase-activating polypeptide (PAC1-R) in reactive astrocytes; https://cir.nii.ac.jp/crid/1362544421110848384; Specificity and timing of neocortical transcriptome changes in response to BDNF gene ablation during embryogenesis or adulthood; https://cir.nii.ac.jp/crid/1362825894443252864; “Stemness” Does Not Explain the Repair of Many Tissues by Mesenchymal Stem/Multipotent Stromal Cells (MSCs); https://cir.nii.ac.jp/crid/1362825895757055872; Bone marrow-derived mesenchymal stromal cells for the repair of central nervous system injury; https://cir.nii.ac.jp/crid/1362825895813044224; Human stem/progenitor cells from bone marrow promote neurogenesis of endogenous neural stem cells in the hippocampus of mice; https://cir.nii.ac.jp/crid/1362825896103213440; Mesenchymal Stem/Stromal Cells (MSCs): Role as Guardians of Inflammation; https://cir.nii.ac.jp/crid/1362825896314513664; Concise Review: Bone Marrow for the Treatment of Spinal Cord Injury: Mechanisms and Clinical Applications; https://cir.nii.ac.jp/crid/1363107368680000384; Stem/progenitor cells from bone marrow decrease neuronal death in global ischemia by modulation of inflammatory/immune responses; https://cir.nii.ac.jp/crid/1363388845203717632; Pituitary adenylate cyclase-activating polypeptide (PACAP) decreases ischemic neuronal cell death in association with IL-6; https://cir.nii.ac.jp/crid/1363670318956958976; Progesterone increases mRNA levels of pituitary adenylate cyclase-activating polypeptide (PACAP) and type I PACAP receptor (PAC1) in the rat hypothalamus; https://cir.nii.ac.jp/crid/1363670320861356544; Intravenous hMSCs Improve Myocardial Infarction in Mice because Cells Embolized in Lung Are Activated to Secrete the Anti-inflammatory Protein TSG-6; https://cir.nii.ac.jp/crid/1363951793287653632; Role of PACAP in Ischemic Neural Death; https://cir.nii.ac.jp/crid/1363951795240816000; Alternative Activation of Macrophages: Mechanism and Functions; https://cir.nii.ac.jp/crid/1364233269048334592; Basso Mouse Scale for Locomotion Detects Differences in Recovery after Spinal Cord Injury in Five Common Mouse Strains; https://cir.nii.ac.jp/crid/1364233269224748928
• 連携機関・データベース: 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/
• 提供元機関・データベース: Crossref; https://www.crossref.org; 科学研究費助成事業データベース; https://kaken.nii.ac.jp/ja

• 要約等: Adult human mesenchymal stem/stromal cells (hMSCs) from bone marrow have been reported to exhibit beneficial effects on spinal cord injury (SCI). A ne...