MiR-494-3p regulates mitochondrial biogenesis and thermogenesis through PGC1-α signalling in beige adipocytes

• 資料種別: 記事
• タイトル: MiR-494-3p regulates mitochondrial biogenesis and thermogenesis through PGC1-α signalling in beige adipocytes
• 著者標目: Mengistu Lemecha; https://orcid.org/0000-0002-4162-5053; Katsutaro Morino; https://orcid.org/0000-0003-2420-3817; Takeshi Imamura; Hirotaka Iwasaki; https://orcid.org/0000-0002-0528-4263; Natsuko Ohashi; Shogo Ida; Daisuke Sato; Osamu Sekine; Satoshi Ugi; Hiroshi Maegawa; https://orcid.org/0000-0002-4611-8149
• 出版年月日等: 2018-10-10
• 出版年（W3CDTF）: 2018-10-10
• タイトル（掲載誌）: Scientific Reports
• 巻号年月日等（掲載誌）: 8 1
• 掲載巻: 8
• 掲載号: 1
• 掲載ページ: 15096-
• 掲載年月日（W3CDTF）: 2018-10-10
• 出版事項（掲載誌）: Springer Science and Business Media LLC
• 件名標目: Male; Organelle Biogenesis; Temperature; Gene Expression; Thermogenesis; Models, Biological; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Article; Mitochondria; Mice; MicroRNAs; Oxygen Consumption; Genes, Reporter; 3T3-L1 Cells; Animals; RNA Interference; Adipocytes, Beige; RNA, Messenger; 3' Untranslated Regions; Signal Transduction
• 対象利用者: 一般
• 標準番号（その他）: PMID : 30305668
• DOI: 10.1038/s41598-018-33438-3
• 作成日（W3CDTF）: 2018-10-04
• オンライン閲覧公開範囲: インターネット公開
• 著作権情報: https://creativecommons.org/licenses/by/4.0
• 関連情報（URI）: https://www.nature.com/articles/s41598-018-33438-3.pdf; https://www.nature.com/articles/s41598-018-33438-3
• 参照: MicroRNA-494-3p inhibits formation of fast oxidative muscle fibres by targeting E1A-binding protein p300 in human-induced pluripotent stem cells.; https://cir.nii.ac.jp/crid/1050569094162047104; Linoleic Acid Upregulates Microrna-494 to Induce Quiescence in Colorectal Cancer; https://cir.nii.ac.jp/crid/1360294643795918208; Cynandione A induces adipogenesis and beige adipocyte-related phenotype in 3T3-L1 cells; https://cir.nii.ac.jp/crid/1360572092649721344; Regulatory expression of uncoupling protein 1 and its related genes by endogenous activity of the transforming growth factor‐β family in bovine myogenic cells; https://cir.nii.ac.jp/crid/1360853567552430464; PERK-Mediated Suppression of microRNAs by Sildenafil Improves Mitochondrial Dysfunction in Heart Failure; https://cir.nii.ac.jp/crid/1360853567697288192
• 参照: Mitochondrial Actions for Fat Browning and Energy Expenditure in White Adipose Tissue; https://cir.nii.ac.jp/crid/1360011143784611072; Nuclear Outsourcing of RNA Interference Components to Human Mitochondria; https://cir.nii.ac.jp/crid/1360011143995879040; Isoproterenol Increases Uncoupling, Glycolysis, and Markers of Beiging in Mature 3T3-L1 Adipocytes; https://cir.nii.ac.jp/crid/1360011144831328256; Muscle-Enriched MicroRNAs Isolated from Whole Blood Are Regulated by Exercise and Are Potential Biomarkers of Cardiorespiratory Fitness; https://cir.nii.ac.jp/crid/1360011144893276416; Resistin Inhibits the Synthesis of Insulin by miR-494 through Traget on CREB1; https://cir.nii.ac.jp/crid/1360011145191700736; MicroRNAs; https://cir.nii.ac.jp/crid/1360292617909472512; Intermittent cold exposure improves glucose homeostasis associated with brown and white adipose tissues in mice; https://cir.nii.ac.jp/crid/1360292618718998784; Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human; https://cir.nii.ac.jp/crid/1360292620759625344; Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1; https://cir.nii.ac.jp/crid/1360574094962018688; A New Era in Brown Adipose Tissue Biology: Molecular Control of Brown Fat Development and Energy Homeostasis; https://cir.nii.ac.jp/crid/1360574095045545216; UCP1 in Brite/Beige Adipose Tissue Mitochondria Is Functionally Thermogenic; https://cir.nii.ac.jp/crid/1360855571283890432; Factors involved in white‐to‐brown adipose tissue conversion and in thermogenesis: a review; https://cir.nii.ac.jp/crid/1361137044914099328; Intermittent Cold Exposure Enhances Fat Accumulation in Mice; https://cir.nii.ac.jp/crid/1361137045340713728; Molecular Mechanisms of Insulin Resistance in Humans and Their Potential Links With Mitochondrial Dysfunction; https://cir.nii.ac.jp/crid/1361418520049863296; Mitochondrial (Dys)function in Adipocyte (De)differentiation and Systemic Metabolic Alterations; https://cir.nii.ac.jp/crid/1361418520508922624; PGC-1α regulation by exercise training and its influences on muscle function and insulin sensitivity; https://cir.nii.ac.jp/crid/1361699994334271744; Adaptive thermogenesis in adipocytes: Is beige the new brown?; https://cir.nii.ac.jp/crid/1361699995093406976; Carboxyatractyloside effects on brown-fat mitochondria imply that the adenine nucleotide translocator isoforms ANT1 and ANT2 may be responsible for basal and fatty-acid-induced uncoupling respectively; https://cir.nii.ac.jp/crid/1361699995860554752; The Role of microRNAs in Mitochondria: Small Players Acting Wide; https://cir.nii.ac.jp/crid/1361981470616898688; Voluntary wheel exercise alters the levels of miR-494 and miR-696 in the skeletal muscle of C57BL/6 mice; https://cir.nii.ac.jp/crid/1361981470628411264; Sequential alterations of microrna expression in hepatocellular carcinoma development and venous metastasis; https://cir.nii.ac.jp/crid/1362262945755631744; Bi-directional interconversion of brite and white adipocytes; https://cir.nii.ac.jp/crid/1362544419628284544; Cold-Inducible SIRT6 Regulates Thermogenesis of Brown and Beige Fat; https://cir.nii.ac.jp/crid/1362544420389292032; Regulation of human subcutaneous adipose tissue blood flow; https://cir.nii.ac.jp/crid/1362825893922223104; Brown and beige fat: development, function and therapeutic potential; https://cir.nii.ac.jp/crid/1362825896005073536; The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria; https://cir.nii.ac.jp/crid/1363107370956256256; Depletion of Tumor-Associated Macrophages Slows the Growth of Chemically Induced Mouse Lung Adenocarcinomas; https://cir.nii.ac.jp/crid/1363107371144331008; Turning WAT into BAT: a review on regulators controlling the browning of white adipocytes; https://cir.nii.ac.jp/crid/1363388843697240320; MicroRNA-494 regulates mitochondrial biogenesis in skeletal muscle through mitochondrial transcription factor A and Forkhead box j3; https://cir.nii.ac.jp/crid/1363388844336354688; Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis; https://cir.nii.ac.jp/crid/1363670319514208768; β₃‐Adrenoceptor knockout in C57BL/6J mice depresses the occurrence of brown adipocytes in white fat; https://cir.nii.ac.jp/crid/1363670319923712896; Regulatory networks of non-coding RNAs in brown/beige adipogenesis; https://cir.nii.ac.jp/crid/1363951795818888320; Induction of Beige-Like Adipocytes in 3T3-L1 Cells; https://cir.nii.ac.jp/crid/1390001206429104384
• 連携機関・データベース: 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/
• 提供元機関・データベース: Crossref; https://www.crossref.org; 科学研究費助成事業データベース; https://kaken.nii.ac.jp/ja

• 要約等: <jats:title>Abstract</jats:title><jats:p>Mitochondria are critical in heat generation in brown and beige adipocytes. Mitochondrial number and function...