IL-22 Upregulates Epithelial Claudin-2 to Drive Diarrhea and Enteric Pathogen Clearance

• 資料種別: 記事
• タイトル: IL-22 Upregulates Epithelial Claudin-2 to Drive Diarrhea and Enteric Pathogen Clearance
• 著者標目: Pei-Yun Tsai; Bingkun Zhang; Wei-Qi He; Juan-Min Zha; Matthew A. Odenwald; Gurminder Singh; Atsushi Tamura; Le Shen; Anne Sailer; Sunil Yeruva; Wei-Ting Kuo; Yang-Xin Fu; Sachiko Tsukita; Jerrold R. Turner
• 出版年月日等: 2017-06
• 出版年（W3CDTF）: 2017-06
• タイトル（掲載誌）: Cell Host & Microbe
• 巻号年月日等（掲載誌）: 21 6
• 掲載巻: 21
• 掲載号: 6
• 掲載ページ: 671-681.e4
• 掲載年月日（W3CDTF）: 2017-06
• ISSN（掲載誌）: 19313128
• 出版事項（掲載誌）: Elsevier BV
• 件名標目: Diarrhea; Cell Membrane Permeability; Interleukins; Sodium; Enterobacteriaceae Infections; Water; Colitis; Epithelium; Immunity, Innate; Tight Junctions; Up-Regulation; Intestines; Mice, Inbred C57BL; Disease Models, Animal; Mice; Animals; Citrobacter rodentium; Cytokines; Claudin-2; Intestinal Mucosa
• 対象利用者: 一般
• 標準番号（その他）: PMID : 28618266
• DOI: 10.1016/j.chom.2017.05.009; https://doi.org/10.1016/j.chom.2017.05.009
• 作成日（W3CDTF）: 2017-06-14
• 著作権情報: https://www.elsevier.com/tdm/userlicense/1.0/; https://www.elsevier.com/legal/tdmrep-license; http://www.elsevier.com/open-access/userlicense/1.0/
• 関連情報（URI）: https://api.elsevier.com/content/article/PII:S1931312817302020?httpAccept=text/xml; https://api.elsevier.com/content/article/PII:S1931312817302020?httpAccept=text/plain; https://pure.teikyo.jp/en/publications/7927e401-3dfe-40a7-858b-fb7525d1ba7f
• 参照: Possible Involvement of the Mucosal Claudin Expression in the Healing of a Refractory Ileocecal Ulcer in a Patient with Crohn's Disease Successfully Treated with Infliximab; https://cir.nii.ac.jp/crid/1390590061158685440; Functional landscape of mechanistic diversity in 27 claudin family members at tight junctions; https://cir.nii.ac.jp/crid/1360308565920784512; Innate immune sensing of rotavirus by intestinal epithelial cells leads to diarrhea; https://cir.nii.ac.jp/crid/1360025431130973312; Claudin-2 upregulation enhances intestinal permeability, immune activation, dysbiosis, and mortality in sepsis; https://cir.nii.ac.jp/crid/1360584341813718016; Differential dependence on microbiota of <scp>IL</scp>‐23/<scp>IL</scp>‐22‐dependent gene expression between the small‐ and large‐intestinal epithelia; https://cir.nii.ac.jp/crid/1050018218945828224; Double mutation of <i>claudin‐1</i> and <i>claudin‐3</i> causes alopecia in infant mice; https://cir.nii.ac.jp/crid/1360298754812579072; High-fat diet aggravates experimental autoimmune pancreatitis through the activation of type I interferon signaling pathways; https://cir.nii.ac.jp/crid/1360017280661296896; Partners in Leaky Gut Syndrome: Intestinal Dysbiosis and Autoimmunity; https://cir.nii.ac.jp/crid/1360013168828507136; Inactivation of paracellular cation-selective claudin-2 channels attenuates immune-mediated experimental colitis in mice; https://cir.nii.ac.jp/crid/1360576118746800640; The Claudins: From Tight Junctions to Biological Systems; https://cir.nii.ac.jp/crid/1360005517323587584; Interleukin 22 Expands Transit-Amplifying Cells While Depleting Lgr5+ Stem Cells via Inhibition of Wnt and Notch Signaling; https://cir.nii.ac.jp/crid/1360568466945054464; Claudin-3 regulates bile canalicular paracellular barrier and cholesterol gallstone core formation in mice; https://cir.nii.ac.jp/crid/1361975841857515520; Clinical importance of IL-22 cascade in IBD; https://cir.nii.ac.jp/crid/1360283690303400064
• 参照: IL-22 suppresses the infection of porcine enteric coronaviruses and rotavirus by activating STAT3 signal pathway; https://cir.nii.ac.jp/crid/1364233269085754624; Aquaporin-3 mediates hydrogen peroxide-dependent responses to environmental stress in colonic epithelia; https://cir.nii.ac.jp/crid/1362825896204548736; Claudin‐2‐mediated cation and water transport share a common pore; https://cir.nii.ac.jp/crid/1361418519745616384; Interleukin-13 Receptor α1-Dependent Responses in the Intestine Are Critical to Parasite Clearance; https://cir.nii.ac.jp/crid/1363670321085339264; Complementarity and redundancy of IL-22-producing innate lymphoid cells; https://cir.nii.ac.jp/crid/1362262944480247424; Epithelial-intrinsic IKKα expression regulates group 3 innate lymphoid cell responses and antibacterial immunity; https://cir.nii.ac.jp/crid/1361981470239170176; Targeted colonic claudin-2 expression renders resistance to epithelial injury, induces immune suppression, and protects from colitis; https://cir.nii.ac.jp/crid/1360855570497431040; Epithelial IL-22RA1-Mediated Fucosylation Promotes Intestinal Colonization Resistance to an Opportunistic Pathogen; https://cir.nii.ac.jp/crid/1360292621204219392; Separation of Intact Intestinal Epithelium from Mesenchyme; https://cir.nii.ac.jp/crid/1363388844695742080; STAT6 Deficiency Ameliorates Severity of Oxazolone Colitis by Decreasing Expression of Claudin-2 and Th2-Inducing Cytokines; https://cir.nii.ac.jp/crid/1364233268912318976; Loss of Claudins 2 and 15 From Mice Causes Defects in Paracellular Na+ Flow and Nutrient Transport in Gut and Leads to Death from Malnutrition; https://cir.nii.ac.jp/crid/1360846641908502528; Claudin-2 Regulates Colorectal Inflammation via Myosin Light Chain Kinase-Dependent Signaling; https://cir.nii.ac.jp/crid/1360004231345373440; Th22 Cells Are an Important Source of IL-22 for Host Protection against Enteropathogenic Bacteria; https://cir.nii.ac.jp/crid/1361981469311620736; Activated fluid transport regulates bacterial-epithelial interactions and significantly shifts the murine colonic microbiome; https://cir.nii.ac.jp/crid/1360011145736272256; Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium; https://cir.nii.ac.jp/crid/1360565166931746304; Polyethylene glycol diminishes pathological effects of<i>Citrobacter rodentium</i>infection by blocking bacterial attachment to the colonic epithelia; https://cir.nii.ac.jp/crid/1361418518637715968; Interleukin-6 (IL-6) Regulates Claudin-2 Expression and Tight Junction Permeability in Intestinal Epithelium; https://cir.nii.ac.jp/crid/1360846642074168448; Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function; https://cir.nii.ac.jp/crid/1361137046231840000; Epithelial Myosin Light Chain Kinase Activation Induces Mucosal Interleukin-13 Expression to Alter Tight Junction Ion Selectivity; https://cir.nii.ac.jp/crid/1362262944260235392; A Comprehensive Proteomic Analysis of the Type III Secretome of Citrobacter rodentium; https://cir.nii.ac.jp/crid/1363107368512189440; Intestinal mucosal barrier function in health and disease; https://cir.nii.ac.jp/crid/1361699994218980096; Physiology and Function of the Tight Junction; https://cir.nii.ac.jp/crid/1361418521372612096; STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing; https://cir.nii.ac.jp/crid/1361981471294705152; TNFα up-regulates claudin-2 expression in epithelial HT-29/B6 cells via phosphatidylinositol-3-kinase signaling; https://cir.nii.ac.jp/crid/1362544418615642752; Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens; https://cir.nii.ac.jp/crid/1361699995634355200; Claudin profiling in the mouse during postnatal intestinal development and along the gastrointestinal tract reveals complex expression patterns; https://cir.nii.ac.jp/crid/1361137044486142976; Attaching and effacing pathogen-induced tight junction disruption in vivo; https://cir.nii.ac.jp/crid/1360292620188846336; Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo; https://cir.nii.ac.jp/crid/1362262945522935680; Phenotype analysis of aquaporin-8 null mice; https://cir.nii.ac.jp/crid/1361699995459970816; Regulatory Sequences of the Mouse Villin Gene That Efficiently Drive Transgenic Expression in Immature and Differentiated Epithelial Cells of Small and Large Intestines; https://cir.nii.ac.jp/crid/1360011145358529152; Adverse Effect of Lomotil Therapy in Shigellosis; https://cir.nii.ac.jp/crid/1363670319125658880; A BACTERIOLOGICAL AND CLINICAL CONSIDERATION OF BACILLARY DYSENTERY IN ADULTS AND CHILDREN; https://cir.nii.ac.jp/crid/1364233271074989056
• 連携機関・データベース: 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/
• 提供元機関・データベース: Crossref; https://www.crossref.org; 科学研究費助成事業データベース; https://kaken.nii.ac.jp/ja; 学術機関リポジトリデータベース; https://irdb.nii.ac.jp

• 要約等: <p>Diarrhea is a host response to enteric pathogens, but its impact on pathogenesis remains poorly defined. By infecting mice with the attaching and effacing bacteria Citrobacter rodentium, we defined the mechanisms and contributions of diarrhea and intestinal barrier loss to host defense. Increased permeability occurred within 2 days of infection and coincided with IL-22-dependent upregulation of the epithelial tight junction protein claudin-2. Permeability increases were limited to small molecules, as expected for the paracellular water and Na⁺ channel formed by claudin-2. Relative to wild-type, claudin-2-deficient mice experienced severe disease, including increased mucosal colonization by C. rodentium, prolonged pathogen shedding, exaggerated cytokine responses, and greater tissue injury. Conversely, transgenic claudin-2 overexpression reduced disease severity. Chemically induced osmotic diarrhea reduced colitis severity and C. rodentium burden in claudin-2-deficient, but not transgenic, mice, demonstrating that claudin-2-mediated protection is the result of enhanced water efflux. Thus, IL-22-induced claudin-2 upregulation drives diarrhea and pathogen clearance.</p>
• DOI: 10.1016/j.chom.2017.05.009; https://doi.org/10.1016/j.chom.2017.05.009
• 異版（DOI）: 10.1016/j.chom.2017.05.009; https://doi.org/10.1016/j.chom.2017.05.009
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 帝京大学 : 帝京大学研究・教育リポジトリ