Noxa determines localization and stability of MCL-1 and consequently ABT-737 sensitivity in small cell lung cancer

• 資料種別: 記事
• タイトル: Noxa determines localization and stability of MCL-1 and consequently ABT-737 sensitivity in small cell lung cancer
• 著者標目: W Nakajima; M A Hicks; N Tanaka; G W Krystal; H Harada
• 出版年月日等: 2014-02-13
• 出版年（W3CDTF）: 2014-02-13
• タイトル（掲載誌）: Cell Death & Disease
• 巻号年月日等（掲載誌）: 5 2
• 掲載巻: 5
• 掲載号: 2
• 掲載ページ: e1052-e1052
• 掲載年月日（W3CDTF）: 2014-02-13
• 出版事項（掲載誌）: Springer Science and Business Media LLC
• 件名標目: Proteasome Endopeptidase Complex; Lung Neoplasms; Cell Survival; Antineoplastic Agents; Apoptosis; Transfection; Piperazines; Nitrophenols; Animals; Humans; Phosphorylation; Mice, Knockout; Sulfonamides; Dose-Response Relationship, Drug; ABT-737; Protein Stability; Noxa; Biphenyl Compounds; Ubiquitination; Small Cell Lung Carcinoma; Mitochondria; Protein Transport; lung cancer; HEK293 Cells; Proto-Oncogene Proteins c-bcl-2; protein stability; Mutation; Myeloid Cell Leukemia Sequence 1 Protein; RNA Interference; Original Article; MCL-1; HeLa Cells
• 対象利用者: 一般
• 標準番号（その他）: PMID : 24525728
• DOI: 10.1038/cddis.2014.6
• 作成日（W3CDTF）: 2014-02-13
• オンライン閲覧公開範囲: インターネット公開
• 著作権情報: http://www.springer.com/tdm
• 関連情報（URI）: http://www.nature.com/articles/cddis20146.pdf; http://www.nature.com/articles/cddis20146; https://www.nature.com/articles/cddis20146.pdf
• 参照: Unmasking BCL-2 Addiction in Synovial Sarcoma by Overcoming Low NOXA; https://cir.nii.ac.jp/crid/1360576118788705152; Cisplatin-induced apoptosis in non-small-cell lung cancer cells is dependent on Bax- and Bak-induction pathway and synergistically activated by BH3-mimetic ABT-263 in p53 wild-type and mutant cells; https://cir.nii.ac.jp/crid/1360848656931702784
• 参照: Phosphate-binding tag: a new tool to visualized phosphorylated proteins; https://cir.nii.ac.jp/crid/1050014791011100928; ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor; https://cir.nii.ac.jp/crid/1360011143717204736; BH3 Profiling Identifies Three Distinct Classes of Apoptotic Blocks to Predict Response to ABT-737 and Conventional Chemotherapeutic Agents; https://cir.nii.ac.jp/crid/1360011145079030656; NCI-navy medical oncology branch cell line data base; https://cir.nii.ac.jp/crid/1360292617906604032; Mcl-1 Ubiquitination and Destruction; https://cir.nii.ac.jp/crid/1360292619904187008; Extensive-disease small-cell lung cancer: the thrill of victory; the agony of defeat.; https://cir.nii.ac.jp/crid/1360292620282095360; Influence of Bcl-2 Family Members on the Cellular Response of Small-Cell Lung Cancer Cell Lines to ABT-737; https://cir.nii.ac.jp/crid/1360292621613853568; Mcl‐1; the molecular regulation of protein function; https://cir.nii.ac.jp/crid/1360574093492205952; Increased Dose-Intensity in Small-Cell Lung Cancer: A Failed Strategy?; https://cir.nii.ac.jp/crid/1360574093645757824; The Bcl-2 apoptotic switch in cancer development and therapy; https://cir.nii.ac.jp/crid/1361137044376215936; Small-cell lung cancer; https://cir.nii.ac.jp/crid/1361137045550762240; Involvement of BH3-only proteins in hematologic malignancies; https://cir.nii.ac.jp/crid/1361418519648430080; An inhibitor of Bcl-2 family proteins induces regression of solid tumours; https://cir.nii.ac.jp/crid/1361699993959998208; The Molecular Mechanism of Noxa-induced Mitochondrial Dysfunction in p53-Mediated Cell Death; https://cir.nii.ac.jp/crid/1361699995846782720; The BCL-2 protein family: opposing activities that mediate cell death; https://cir.nii.ac.jp/crid/1361981469352187008; Phase I Study of Navitoclax (ABT-263), a Novel Bcl-2 Family Inhibitor, in Patients With Small-Cell Lung Cancer and Other Solid Tumors; https://cir.nii.ac.jp/crid/1362262943325851264; ‘Seed’ analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737; https://cir.nii.ac.jp/crid/1362262945788403712; NOXA, a sensor of proteasome integrity, is degraded by 26S proteasomes by an ubiquitin-independent pathway that is blocked by MCL-1; https://cir.nii.ac.jp/crid/1362262946140457472; Targeting Multiple Arms of the Apoptotic Regulatory Machinery; https://cir.nii.ac.jp/crid/1362825893923016064; Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis; https://cir.nii.ac.jp/crid/1363388843889955328; Cisplatin, Etoposide, and Paclitaxel in the Treatment of Patients With Extensive Small-Cell Lung Carcinoma; https://cir.nii.ac.jp/crid/1363388844100877952; Role of NOXA and its ubiquitination in proteasome inhibitor-induced apoptosis in chronic lymphocytic leukemia cells; https://cir.nii.ac.jp/crid/1363670319834011392; Differential Targeting of Prosurvival Bcl-2 Proteins by Their BH3-Only Ligands Allows Complementary Apoptotic Function; https://cir.nii.ac.jp/crid/1363670320726845056; Proapoptotic Bak is sequestered by Mcl-1 and Bcl-x_L, but not Bcl-2, until displaced by BH3-only proteins; https://cir.nii.ac.jp/crid/1363951793764371840; Alterations in the Noxa/Mcl-1 axis determine sensitivity of small cell lung cancer to the BH3 mimetic ABT-737; https://cir.nii.ac.jp/crid/1363951793941518080; The BCL-2 Family Reunion; https://cir.nii.ac.jp/crid/1364233269549116032; Targeting the B-Cell Lymphoma/Leukemia 2 Family in Cancer; https://cir.nii.ac.jp/crid/1364233270095129728; Activity of the Bcl-2 Family Inhibitor ABT-263 in a Panel of Small Cell Lung Cancer Xenograft Models; https://cir.nii.ac.jp/crid/1364233270301764096
• 連携機関・データベース: 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/
• 提供元機関・データベース: Crossref; https://www.crossref.org; 科学研究費助成事業データベース; https://kaken.nii.ac.jp/ja

• 要約等: The sensitivity to ABT-737, a prototype BH3 mimetic drug, varies in a broad range in small cell lung cancer (SCLC) cells. We have previously shown tha...