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Liver-specific deletion of Ngly1 causes abnormal nuclear morphology and lipid metabolism under food stress
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Liver-specific deletion of Ngly1 causes abnormal nuclear morphology and lipid metabolism under food stress
- 資料種別
- 記事
- 著者
- Haruhiko Fujihiraほか
- 出版者
- Elsevier BV
- 出版年
- 2020-03
- 資料形態
- デジタル
- 掲載誌名
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1866 3
- 掲載ページ
- p.165588-
資料詳細
要約等：
- The cytoplasmic peptide:N-glycanase (Ngly1) is a de-N-glycosylating enzyme that cleaves N-glycans from misfolded glycoproteins and is involved in endo...
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デジタル
- 資料種別
- 記事
- 著者標目
- 出版年月日等
- 2020-03
- 出版年（W3CDTF）
- 2020-03
- タイトル（掲載誌）
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- 巻号年月日等（掲載誌）
- 1866 3
- 掲載巻
- 1866
- 掲載号
- 3
- 掲載ページ
- 165588-
- 掲載年月日（W3CDTF）
- 2020-03
- ISSN（掲載誌）
- 09254439
- 出版事項（掲載誌）
- Elsevier BV
- 件名標目
- 対象利用者
- 一般
- 標準番号（その他）
- PMID : 31733337
- DOI
- 10.1016/j.bbadis.2019.165588
- 作成日（W3CDTF）
- 2019-11-13
- 著作権情報
- https://www.elsevier.com/tdm/userlicense/1.0/https://www.elsevier.com/legal/tdmrep-licensehttp://www.elsevier.com/open-access/userlicense/1.0/
- 関連情報（URI）
- 参照
- Direct evidence of cytosolic PNGase activity in <i>Arabidopsis thaliana</i>: <i>in vitro</i> assay system for plant cPNGase activityPhysiological importance of NGLY1, as revealed by rodent model analysesNGLY1: A fascinating, multifunctional moleculeNgly1 −/− rats develop neurodegenerative phenotypes and pathological abnormalities in their peripheral and central nervous systemsCytosolic N-GlcNAc proteins are formed by the action of endo-β-N-acetylglucosaminidaseJF1/B6F1 Ngly1[⁻/⁻] mouse as an isogenic animal model of NGLY1 deficiency
- 参照
- Lethality of mice bearing a knockout of the Ngly1-gene is partially rescued by the additional deletion of the Engase genec‐Jun N‐terminal kinase activation by oxidative stress suppresses retinoid signaling through proteasomal degradation of retinoic acid receptor α protein in hepatic cellsEvidence for an Essential Deglycosylation-Independent Activity of PNGase in Drosophila melanogasterAutophagy regulates lipid metabolismClinical application of exome sequencing in undiagnosed genetic conditionsTranscription Factor Nrf1 Mediates the Proteasome Recovery Pathway after Proteasome Inhibition in Mammalian CellsTranscription Factor Nrf1 Negatively Regulates the Cystine/Glutamate Transporter and Lipid-Metabolizing EnzymesEndurance exercise training and high-fat diet differentially affect composition of diacylglycerol molecular species in rat skeletal muscleDeficiency in the nuclear‐related factor erythroid 2 transcription factor (<scp>N</scp>rf1) leads to genetic instabilityImaging analysis reveals mechanistic differences between first- and second-phase insulin exocytosisProspective phenotyping of NGLY1-CDDG, the first congenital disorder of deglycosylationOxidative Stress Induces Persistent Telomeric DNA Damage Responsible for Nuclear Morphology Change in Mammalian CellsTissue-specific regulation of BMP signaling by Drosophila N-glycanase 1Proteasomal Degradation Is Transcriptionally Controlled by TCF11 via an ERAD-Dependent Feedback LoopEndo-β- <i>N</i> -acetylglucosaminidase forms <i>N</i> -GlcNAc protein aggregates during ER-associated degradation in Ngly1-defective cellsN-glycanase NGLY1 regulates mitochondrial homeostasis and inflammation through NRF1Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasiaA Homeostatic Shift Facilitates Endoplasmic Reticulum Proteostasis through Transcriptional Integration of Proteostatic Stress Response PathwaysCentral nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunctionNF-E2-Related Factor 1 (Nrf1) Serves as a Novel Regulator of Hepatic Lipid Metabolism through Regulation of the <i>Lipin1</i> and <i>PGC-1</i>β GenesSTAR: ultrafast universal RNA-seq alignerclusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters<tt>edgeR</tt> : a Bioconductor package for differential expression analysis of digital gene expression dataSimultaneous activation of p38 and JNK by arachidonic acid stimulates the cytosolic phospholipase A2-dependent synthesis of lipid droplets in human monocytesProteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1Mutations in NGLY1 cause an inherited disorder of the endoplasmic reticulum–associated degradation pathwayCatabolism of N-glycoproteins in mammalian cells: Molecular mechanisms and genetic disorders related to the processesA RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATIONUnexplained death in patients with <i>NGLY1</i> mutations may be explained by adrenal insufficiencyDefects in the Neuroendocrine Axis Contribute to Global Development Delay in a <i>Drosophila</i> Model of NGLY1 DeficiencyTrehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosisDOSE: an R/Bioconductor package for disease ontology semantic and enrichment analysisChanging gears in Nrf1 research, from mechanisms of regulation to its role in disease and preventionSoftware for Computing and Annotating Genomic RangesCre activity in fetal <i>albCre</i> mouse hepatocytes: Utility for developmental studiesMulti‐systemic involvement in NGLY1‐related disorder caused by two novel mutationsNGLY1 mutation causes neuromotor impairment, intellectual disability, and neuropathyVascular actions of 20-HETECytochrome P450 CYP2J9, a New Mouse Arachidonic Acid ω-1 Hydroxylase Predominantly Expressed in BrainTranscriptome and functional analysis in a Drosophila model of NGLY1 deficiency provides insight into therapeutic approachesNovel genetic causes for cerebral visual impairmentMolecular mechanisms underlying chemical liver injuryMitochondrial function requires NGLY1Liver enzyme alteration: a guide for cliniciansNrf1 and Nrf2 Play Distinct Roles in Activation of Antioxidant Response Element-dependent GenesDual Roles for Glucokinase in Glucose Homeostasis as Determined by Liver and Pancreatic β Cell-specific Gene Knock-outs Using Cre RecombinaseThe role of bile acids in nonalcoholic fatty liver disease and nonalcoholic steatohepatitisMolecular and cellular basis for the unique functioning of Nrf1, an indispensable transcription factor for maintaining cell homoeostasis and organ integrityInhibition of NGLY1 Inactivates the Transcription Factor Nrf1 and Potentiates Proteasome Inhibitor CytotoxicityUDP-Glucuronosyltransferase Expression in Mouse Liver Is Increased in Obesity- and Fasting-Induced SteatosisStructure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily
- 連携機関・データベース
- 国立情報学研究所 : CiNii Research
- 提供元機関・データベース
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