Deletion of Gb3 Synthase in Mice Resulted in the Attenuation of Bone Formation via Decrease in Osteoblasts

• 資料種別: 記事
• タイトル: Deletion of Gb3 Synthase in Mice Resulted in the Attenuation of Bone Formation via Decrease in Osteoblasts
• 著者標目: Kazunori Hamamura; https://orcid.org/0000-0002-8143-338X; Kosuke Hamajima; Shoyoku Yo; Yoshitaka Mishima; Koichi Furukawa; https://orcid.org/0000-0002-3321-9784; Makoto Uchikawa; Yuji Kondo; Hironori Mori; Hisataka Kondo; Kenjiro Tanaka; Ken Miyazawa; Shigemi Goto; Akifumi Togari
• 出版年月日等: 2019-09-18
• 出版年（W3CDTF）: 2019-09-18
• タイトル（掲載誌）: International Journal of Molecular Sciences
• 巻号年月日等（掲載誌）: 20 18
• 掲載巻: 20
• 掲載号: 18
• 掲載ページ: 4619-
• 掲載年月日（W3CDTF）: 2019-09-18
• 出版事項（掲載誌）: MDPI AG
• 件名標目: Male; Mice, Knockout; Osteoblasts; glycosphingolipids; osteoblasts; Osteoclasts; Galactosyltransferases; Article; Glycosphingolipids; Cell Line; Mice; RAW 264.7 Cells; globoside (Gb4); Osteogenesis; Animals; bone metabolism; Cells, Cultured; Gene Deletion
• 対象利用者: 一般
• 標準番号（その他）: PMID : 31540393
• DOI: 10.3390/ijms20184619
• 作成日（W3CDTF）: 2019-09-18
• オンライン閲覧公開範囲: インターネット公開
• 著作権情報: https://creativecommons.org/licenses/by/4.0/
• 関連情報（URI）: https://www.mdpi.com/1422-0067/20/18/4619/pdf
• 参照: Globo-series Gb4 activates ERK and promotes the proliferation of osteoblasts; https://cir.nii.ac.jp/crid/1360302865554734080; Regulation of Glycosylation in Bone Metabolism; https://cir.nii.ac.jp/crid/1360302865560556032; Attenuation of Bone Formation through a Decrease in Osteoblasts in Mutant Mice Lacking the GM2/GD2 Synthase Gene; https://cir.nii.ac.jp/crid/1360861704786276608
• 参照: New era of research on cancer‐associated glycosphingolipids; https://cir.nii.ac.jp/crid/1050583647829294336; Glycosphingolipids in the Regulation of the Nervous System; https://cir.nii.ac.jp/crid/1360004230480743552; Systemic administration of low-dose naltrexone increases bone mass due to blockade of opioid growth factor receptor signaling in mice osteoblasts; https://cir.nii.ac.jp/crid/1360004232348853888; TLR4–MD-2 complex is negatively regulated by an endogenous ligand, globotetraosylceramide; https://cir.nii.ac.jp/crid/1360004233959326720; Functional Activation of Src Family Kinase Yes Protein Is Essential for the Enhanced Malignant Properties of Human Melanoma Cells Expressing Ganglioside GD3; https://cir.nii.ac.jp/crid/1360004233976825344; Fine tuning of cell signals by glycosylation; https://cir.nii.ac.jp/crid/1360004234621172096; Effects of gangliosides on the differentiation of human mesenchymal stem cells into osteoblasts by modulating epidermal growth factor receptors; https://cir.nii.ac.jp/crid/1360011144694720896; The Blood Group P1 Synthase Gene Is Identical to the Gb3/CD77 Synthase Gene; https://cir.nii.ac.jp/crid/1360011146192946688; <scp>α_1B</scp>‐Adrenoceptor signalling regulates bone formation through the up‐regulation of CCAAT/enhancer‐binding protein δ expression in osteoblasts; https://cir.nii.ac.jp/crid/1360285710462323072; Efficient generation of useful monoclonal antibodies reactive with globotriaosylceramide using knockout mice lacking Gb3/CD77 synthase; https://cir.nii.ac.jp/crid/1360567181311831040; Globoside accelerates the differentiation of dental epithelial cells into ameloblasts; https://cir.nii.ac.jp/crid/1360567183361326976; GM1 / GD1b / GA1 synthase expression results in the reduced cancer phenotypes with modulation of composition and raft‐localization of gangliosides in a melanoma cell line; https://cir.nii.ac.jp/crid/1360846643109248640; Glycolipids: Essential regulator of neuro-inflammation, metabolism and gliomagenesis; https://cir.nii.ac.jp/crid/1360848656925187328; Erk Is Essential for Growth, Differentiation, Integrin Expression, and Cell Function in Human Osteoblastic Cells; https://cir.nii.ac.jp/crid/1361418519712022016; Inhibition of ganglioside GD1a synthesis suppresses the differentiation of human mesenchymal stem cells into osteoblasts; https://cir.nii.ac.jp/crid/1361418519772077056; Functional Roles of Gangliosides in Neurodevelopment: An Overview of Recent Advances; https://cir.nii.ac.jp/crid/1361699993427385472; Wnt signaling in osteoblasts and bone diseases; https://cir.nii.ac.jp/crid/1361699994585211392; Gangliosides as a potential new class of stem cell markers: the case of GD1a in human bone marrow mesenchymal stem cells; https://cir.nii.ac.jp/crid/1361699995962504064; Pathogenesis of shigella diarrhea. XI. Isolation of a shigella toxin-binding glycolipid from rabbit jejunum and HeLa cells and its identification as globotriaosylceramide.; https://cir.nii.ac.jp/crid/1361699996030076416; Establishment of human osteoblastic cells derived from periosteum in culture; https://cir.nii.ac.jp/crid/1361699996148551808; Differential effects of glycosphingolipids on protein kinase C activity in PC12D pheochromocytoma cells; https://cir.nii.ac.jp/crid/1362262943360341120; GM1 Ganglioside Promotes Osteogenic Differentiation of Human Tendon Stem Cells; https://cir.nii.ac.jp/crid/1362262945926168064; Globoside promotes activation of ERK by interaction with the epidermal growth factor receptor; https://cir.nii.ac.jp/crid/1362544420210849536; Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and β-catenin signaling; https://cir.nii.ac.jp/crid/1362825894620056704; Globoside-dependent Adhesion of Human Embryonal Carcinoma Cells, Based on Carbohydrate-Carbohydrate Interaction, Initiates Signal Transduction and Induces Enhanced Activity of Transcription Factors AP1 and CREB; https://cir.nii.ac.jp/crid/1362825896340235776; Surface marker antigens in the characterization of human embryonic stem cells; https://cir.nii.ac.jp/crid/1363388843417140992; Targeted Disruption of Gb3/CD77 Synthase Gene Resulted in the Complete Deletion of Globo-series Glycosphingolipids and Loss of Sensitivity to Verotoxins; https://cir.nii.ac.jp/crid/1363388845514178944; PKCα suppresses osteoblastic differentiation; https://cir.nii.ac.jp/crid/1363670319054523520; Defects of glycosyltransferase activities in human fibroblasts of Pk and p blood group phenotypes.; https://cir.nii.ac.jp/crid/1363670320720157824; Deficiency of GD3 Synthase in Mice Resulting in the Attenuation of Bone Loss with Aging; https://cir.nii.ac.jp/crid/1363946393981763968; Monoclonal antibody against a Burkitt lymphoma-associated antigen.; https://cir.nii.ac.jp/crid/1363951794635493632; Stage-specific embryonic antigens (SSEA-3 and -4) are epitopes of a unique globo-series ganglioside isolated from human teratocarcinoma cells.; https://cir.nii.ac.jp/crid/1364233268177229952; In vitro and in silico analysis of an inhibitory mechanism of osteoclastogenesis by salubrinal and guanabenz; https://cir.nii.ac.jp/crid/1364233268933129728; Glycosynapses: microdomains controlling carbohydrate-dependent cell adhesion and signaling; https://cir.nii.ac.jp/crid/1364233270137773184; Zinc Promotes Osteoblast Differentiation in Human Mesenchymal Stem Cells Via Activation of the cAMP-PKA-CREB Signaling Pathway; https://cir.nii.ac.jp/crid/1364233270572579968; The P blood group system: Recent progress in immunochemistry and genetics; https://cir.nii.ac.jp/crid/1370568694261482496; Immunochemical study on the red blood cells. I. Globoside, as the agglutinogen of the ABO system on erythrocytes; https://cir.nii.ac.jp/crid/1370568694261482509; Conditioned medium from rat dental pulp reduces the number of osteoclasts via attenuation of adhesiveness in osteoclast precursors; https://cir.nii.ac.jp/crid/1390001288072025600; Elucidation of the enigma of glycosphingolipids in the regulation of inflammation and degeneration; https://cir.nii.ac.jp/crid/1390282763103043200
• 連携機関・データベース: 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/
• 提供元機関・データベース: Crossref; https://www.crossref.org; 科学研究費助成事業データベース; https://kaken.nii.ac.jp/ja

• 要約等: <jats:p>Glycosphingolipids are known to play a role in developing and maintaining the integrity of various organs and tissues. Among glycosphingolipid...