Free cholesterol accumulation in hepatic stellate cells: Mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice

• 資料種別: 記事
• タイトル: Free cholesterol accumulation in hepatic stellate cells: Mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice
• 著者標目: Kengo Tomita; Toshiaki Teratani; Takahiro Suzuki; Motonori Shimizu; Hirokazu Sato; Kazuyuki Narimatsu; Yoshikiyo Okada; Chie Kurihara; Rie Irie; Hirokazu Yokoyama; Katsuyoshi Shimamura; Shingo Usui; Hirotoshi Ebinuma; Hidetsugu Saito; https://ci.nii.ac.jp/author/DA10669951; Chikako Watanabe; Shunsuke Komoto; Atsushi Kawaguchi; Shigeaki Nagao; Kazuo Sugiyama; Ryota Hokari; Takanori Kanai; https://orcid.org/0000-0002-1466-4532; Soichiro Miura; Toshifumi Hibi
• 出版年月日等: 2013-11-18
• 出版年（W3CDTF）: 2013-11-18
• 並列タイトル等: Hepatology, Vol. 00, No. X, 2013 Tomita, Teratani, et al.
• タイトル（掲載誌）: Hepatology
• 巻号年月日等（掲載誌）: 59 1
• 掲載巻: 59
• 掲載号: 1
• 掲載ページ: 154-169
• 掲載年月日（W3CDTF）: 2013-11-18
• ISSN（掲載誌）: 02709139
• 出版事項（掲載誌）: Ovid Technologies (Wolters Kluwer Health)
• 件名標目: Liver Cirrhosis; Male; Down-Regulation; Mice; Transforming Growth Factor beta; Hepatic Stellate Cells; Animals; RNA, Messenger; Membrane Proteins; Macrophage Activation; Up-Regulation; Fatty Liver; Mice, Inbred C57BL; PPAR gamma; Toll-Like Receptor 4; Disease Models, Animal; MicroRNAs; Cholesterol; Receptors, LDL; Signal Transduction; Sterol Regulatory Element Binding Protein 2
• 対象利用者: 一般
• 標準番号（その他）: PMID : 23832448
• DOI: 10.1002/hep.26604
• 作成日（W3CDTF）: 2013-07-06
• 著作権情報: http://doi.wiley.com/10.1002/tdm_license_1.1
• 関連情報（URI）: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fhep.26604; http://onlinelibrary.wiley.com/wol1/doi/10.1002/hep.26604/fullpdf
• 参照: Hepatic stellate cells as key target in liver fibrosis; https://cir.nii.ac.jp/crid/1360002215782835840; SREBP-regulated lipid metabolism: convergent physiology — divergent pathophysiology; https://cir.nii.ac.jp/crid/1360002216814432512; Obeticholic acid protects against hepatocyte death and liver fibrosis in a murine model of nonalcoholic steatohepatitis; https://cir.nii.ac.jp/crid/1360004233486421760; IGF1 suppresses cholesterol accumulation in the liver of growth hormone-deficient mice via the activation of ABCA1; https://cir.nii.ac.jp/crid/1360004236319879808; Lipoprotein Lipase Up‐regulation in Hepatic Stellate Cells Exacerbates Liver Fibrosis in Nonalcoholic Steatohepatitis in Mice; https://cir.nii.ac.jp/crid/1360005514701386880; Vitamin A‐coupled liposome system targeting free cholesterol accumulation in hepatic stellate cells offers a beneficial therapeutic strategy for liver fibrosis; https://cir.nii.ac.jp/crid/1360009142649206144; Redox-dependent PPARγ/Tnpo1 complex formation enhances PPARγ nuclear localization and signaling; https://cir.nii.ac.jp/crid/1360009142830540288; CD8+ tissue-resident memory T cells promote liver fibrosis resolution by inducing apoptosis of hepatic stellate cells; https://cir.nii.ac.jp/crid/1360013168834425472; Lysosomal cholesterol overload in macrophages promotes liver fibrosis in a mouse model of NASH; https://cir.nii.ac.jp/crid/1360021390559709952; Ezetimibe for the treatment of non‐alcoholic fatty liver disease: A meta‐analysis; https://cir.nii.ac.jp/crid/1360283693139766784; Aortic carboxypeptidase–like protein, a WNT ligand, exacerbates nonalcoholic steatohepatitis; https://cir.nii.ac.jp/crid/1360283693783234944; Bile acid metabolism regulated by the gut microbiota promotes non-alcoholic steatohepatitis-associated hepatocellular carcinoma in mice; https://cir.nii.ac.jp/crid/1360283694891808384; Establishment of Novel Mouse Model of Dietary NASH Rapidly Progressing into Liver Cirrhosis and Tumors; https://cir.nii.ac.jp/crid/1360302866852014464; Free cholesterol accumulation in liver sinusoidal endothelial cells exacerbates acetaminophen hepatotoxicity via TLR9 signaling; https://cir.nii.ac.jp/crid/1360567182234374912; Metabolic dysfunction‐associated fatty liver disease directly related to liver fibrosis independent of insulin resistance, hyperlipidemia, and alcohol intake in morbidly obese patients; https://cir.nii.ac.jp/crid/1360579819984237312; Pigment Epithelium-Derived Factor (PEDF) Prevents Hepatic Fat Storage, Inflammation, and Fibrosis in Dietary Steatohepatitis of Mice; https://cir.nii.ac.jp/crid/1360846640305452928; MicroRNA-33 Controls Adaptive Fibrotic Response in the Remodeling Heart by Preserving Lipid Raft Cholesterol; https://cir.nii.ac.jp/crid/1360846643659814144; A Combination of Mitochondrial Oxidative Stress and Excess Fat/Calorie Intake Accelerates Steatohepatitis by Enhancing Hepatic CC Chemokine Production in Mice; https://cir.nii.ac.jp/crid/1360848662514552832; Angiopoietin‐like protein 4 deficiency augments liver fibrosis in liver diseases such as nonalcoholic steatohepatitis in mice through enhanced free cholesterol accumulation in hepatic stellate cells; https://cir.nii.ac.jp/crid/1360853567765222272; Altered bile acid composition and disposition in a mouse model of non-alcoholic steatohepatitis; https://cir.nii.ac.jp/crid/1361975842148342400; Impact of Dietary Fat on the Progression of Liver Fibrosis: Lessons from Animal and Cell Studies; https://cir.nii.ac.jp/crid/1362544421276026880; III．NASHにおける腸内細菌叢と腸内代謝産物の役割; https://cir.nii.ac.jp/crid/1390005506397852928; III．NASH/NAFLDと腸内細菌; https://cir.nii.ac.jp/crid/1390282681426992384; 非アルコール性脂肪肝炎の治療標的としての肝星細胞の活性化機序; https://cir.nii.ac.jp/crid/1390845702296935040; Beneficial effects of dietary tempe prepared with Rhizopus stolonifer on liver function in rats fed with high-fat diet; https://cir.nii.ac.jp/crid/1390845713014695040
• 参照: Cholesterol and 25-Hydroxycholesterol Inhibit Activation of SREBPs by Different Mechanisms, Both Involving SCAP and Insigs; https://cir.nii.ac.jp/crid/1360011145191962112; CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis; https://cir.nii.ac.jp/crid/1360292618687932928; Mitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitis; https://cir.nii.ac.jp/crid/1360292620039507584; A High-Cholesterol Diet Exacerbates Liver Fibrosis in Mice via Accumulation of Free Cholesterol in Hepatic Stellate Cells; https://cir.nii.ac.jp/crid/1360565166931752064; Nonalcoholic steatohepatitis; https://cir.nii.ac.jp/crid/1360574096159898240; Cyclodextrin overcomes deficient lysosome-to-endoplasmic reticulum transport of cholesterol in Niemann-Pick type C cells; https://cir.nii.ac.jp/crid/1360855569715550720; Epigenetic cell fate regulation of hepatic stellate cells; https://cir.nii.ac.jp/crid/1360855570078514048; Cholesterol Addition to ER Membranes Alters Conformation of SCAP, the SREBP Escort Protein that Regulates Cholesterol Metabolism; https://cir.nii.ac.jp/crid/1361137045059711104; Sterols regulate processing of carbohydrate chains of wild-type SREBP cleavage-activating protein (SCAP), but not sterol-resistant mutants Y298C or D443N; https://cir.nii.ac.jp/crid/1361699995678756608; Switch-like Control of SREBP-2 Transport Triggered by Small Changes in ER Cholesterol: A Delicate Balance; https://cir.nii.ac.jp/crid/1361699996413599488; Cholesterol-lowering therapy for the treatment of nonalcoholic fatty liver disease; https://cir.nii.ac.jp/crid/1361981470232853760; Direct Binding of Cholesterol to the Purified Membrane Region of SCAP; https://cir.nii.ac.jp/crid/1362262943798307200; The Cholesterol Derivative 27-Hydroxycholesterol Reduces Steatohepatitis in Mice; https://cir.nii.ac.jp/crid/1362262944432663680; Regulation of Lipid Homeostasis by the Bifunctional SREBF2-miR33a Locus; https://cir.nii.ac.jp/crid/1362544419258038656; Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors; https://cir.nii.ac.jp/crid/1362825893354952576; Tumour necrosis factor signalling through activation of Kupffer cells plays an essential role in liver fibrosis of non-alcoholic steatohepatitis in mice; https://cir.nii.ac.jp/crid/1362825893467150720; 27-Hydroxycholesterol: the first identified endogenous SERM; https://cir.nii.ac.jp/crid/1362825895270050560; TLR4 enhances TGF-β signaling and hepatic fibrosis; https://cir.nii.ac.jp/crid/1363107370419600384; A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood; https://cir.nii.ac.jp/crid/1363388843953502208; Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes; https://cir.nii.ac.jp/crid/1363670320500948736; SREBP in signal transduction: cholesterol metabolism and beyond; https://cir.nii.ac.jp/crid/1363670320874375424
• 連携機関・データベース: 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/
• 提供元機関・データベース: Crossref; https://www.crossref.org; 科学研究費助成事業データベース; https://kaken.nii.ac.jp/ja

• 要約等: Although nonalcoholic steatohepatitis (NASH) is associated with hypercholesterolemia, the underlying mechanisms of this association have not been clar...