Refining the In Vitro and In Vivo Critical Parameters for P-Glycoprotein, [I]/IC₅₀ and [I₂]/IC₅₀, That Allow for the Exclusion of Drug Candidates from Clinical Digoxin Interaction Studies

• 資料種別: 記事
• タイトル: Refining the In Vitro and In Vivo Critical Parameters for P-Glycoprotein, [I]/IC₅₀ and [I₂]/IC₅₀, That Allow for the Exclusion of Drug Candidates from Clinical Digoxin Interaction Studies
• 著者標目: Jack A. Cook; Bo Feng; Katherine S. Fenner; Sarah Kempshall; Ray Liu; Charles Rotter; Dennis A. Smith; Matthew D. Troutman; Mohammed Ullah; Caroline A. Lee
• 出版年月日等: 2010-01-28
• 出版年（W3CDTF）: 2010-01-28
• タイトル（掲載誌）: Molecular Pharmaceutics
• 巻号年月日等（掲載誌）: 7 2
• 掲載巻: 7
• 掲載号: 2
• 掲載ページ: 398-411
• 掲載年月日（W3CDTF）: 2010-01-28
• ISSN（掲載誌）: 15438384
• 出版事項（掲載誌）: American Chemical Society (ACS)
• 対象利用者: 一般
• DOI: 10.1021/mp900174z
• 作成日（W3CDTF）: 2009-12-21
• 関連情報（URI）: https://pubs.acs.org/doi/pdf/10.1021/mp900174z
• 参照: Transporter biology in drug approval: Regulatory aspects; https://cir.nii.ac.jp/crid/1360285707328793728; Physiological based pharmacokinetic modeling to estimate in vivo Ki of ketoconazole on renal P-gp using human drug-drug interaction study result of fesoterodine and ketoconazole; https://cir.nii.ac.jp/crid/1360567182052413184; Nonlinear concentration gradients regulated by the width of channels for observation of half maximal inhibitory concentration (IC₅₀) of transporter proteins; https://cir.nii.ac.jp/crid/1360567183535833984
• 連携機関・データベース: 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/
• 提供元機関・データベース: Crossref; https://www.crossref.org