Activating transcription factor 4 mediates hyperglycaemia-induced endothelial inflammation and retinal vascular leakage through activation of STAT3 in a mouse model of type 1 diabetes

• 資料種別: 記事
• タイトル: Activating transcription factor 4 mediates hyperglycaemia-induced endothelial inflammation and retinal vascular leakage through activation of STAT3 in a mouse model of type 1 diabetes
• 著者標目: Y. Chen; J. J. Wang; J. Li; K. I. Hosoya; R. Ratan; T. Townes; S. X. Zhang
• 出版年月日等: 2012-06-04
• 出版年（W3CDTF）: 2012-06-04
• タイトル（掲載誌）: Diabetologia
• 巻号年月日等（掲載誌）: 55 9
• 掲載巻: 55
• 掲載号: 9
• 掲載ページ: 2533-2545
• 掲載年月日（W3CDTF）: 2012-06-04
• ISSN（掲載誌）: 0012186X
• 出版事項（掲載誌）: Springer Science and Business Media LLC
• 件名標目: Inflammation; Male; Mice, Knockout; STAT3 Transcription Factor; Diabetic Retinopathy; Retinal Vessels; Endoplasmic Reticulum; Activating Transcription Factor 4; Mice; Diabetes Mellitus, Type 1; Gene Expression Regulation; Hyperglycemia; Animals; Endothelium, Vascular; Cells, Cultured; Signal Transduction
• 対象利用者: 一般
• 標準番号（その他）: PMID : 22660795
• DOI: 10.1007/s00125-012-2594-1
• 作成日（W3CDTF）: 2012-06-04
• オンライン閲覧公開範囲: インターネット公開
• 著作権情報: http://www.springer.com/tdm
• 関連情報（URI）: http://link.springer.com/content/pdf/10.1007/s00125-012-2594-1.pdf; http://link.springer.com/article/10.1007/s00125-012-2594-1/fulltext.html; http://link.springer.com/content/pdf/10.1007/s00125-012-2594-1
• 参照: Fasudil inhibits ER stress-induced VCAM-1 expression by modulating unfolded protein response in endothelial cells; https://cir.nii.ac.jp/crid/1360004232000771968; JNK and ATF4 as two important platforms for tumor necrosis factor‐α–stimulated shedding of receptor for advanced glycation end products; https://cir.nii.ac.jp/crid/1360004234785984128; TGP attenuates endoplasmic reticulum stress and regulates the expression of thioredoxin-interacting protein in the kidneys of diabetic rats; https://cir.nii.ac.jp/crid/1390282680714552704; Investigation of the pronounced erythropoietin-induced reduction in hyperglycemia in type 1-like diabetic rats; https://cir.nii.ac.jp/crid/1390282681279051392
• 連携機関・データベース: 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/
• 提供元機関・データベース: Crossref; https://www.crossref.org

• 要約等: There is convincing evidence that endoplasmic reticulum (ER) stress is implicated in the pathogenesis of diabetes and its complications; however, the ...