記事
Computational design of antibody-affinity improvement beyond in vivo maturation
デジタルデータあり（Crossref）
すぐに読む
CiNii Research
Computational design of antibody-affinity improvement beyond in vivo maturation
- 資料種別
- 記事
- 著者
- Shaun M Lippowほか
- 出版者
- Springer Science and Business Media LLC
- 出版年
- 2007-09-23
- 資料形態
- デジタル
- 掲載誌名
- Nature Biotechnology 25 10
- 掲載ページ
- p.1171-1176
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デジタル
- 資料種別
- 記事
- 出版年月日等
- 2007-09-23
- 出版年（W3CDTF）
- 2007-09-23
- タイトル（掲載誌）
- Nature Biotechnology
- 巻号年月日等（掲載誌）
- 25 10
- 掲載巻
- 25
- 掲載号
- 10
- 掲載ページ
- 1171-1176
- 掲載年月日（W3CDTF）
- 2007-09-23
- ISSN（掲載誌）
- 10870156http://id.crossref.org/issn/10870156
- 出版事項（掲載誌）
- Springer Science and Business Media LLC
- 対象利用者
- 一般
- DOI
- 10.1038/nbt1336
- 作成日（W3CDTF）
- 2007-09-23
- 著作権情報
- http://www.springer.com/tdm
- 参照
- Structural features of interfacial tyrosine residue in ROBO1 fibronectin domain‐antibody complex: Crystallographic, thermodynamic, and molecular dynamic analysesComputer-aided antibody designAffinity Improvement of a Therapeutic Antibody by Structure-Based Computational Design: Generation of Electrostatic Interactions in the Transition State Stabilizes the Antibody-Antigen ComplexToward rational antibody design: recent advancements in molecular dynamics simulationsStructural insights into the rational design of a nanobody that binds with high affinity to the SARS-CoV-2 spike variantAnalytical Method for Experimental Validation of Computer-Designed AntibodyHigh-throughput analysis system of interaction kinetics for data-driven antibody designPURE ribosome display and its application in antibody technologyAffinity Improvement of a Cancer-Targeted Antibody through Alanine-Induced Adjustment of Antigen-Antibody InterfaceThermodynamic analyses of amino acid residues at the interface of an antibody B2212A and its antigen roundabout homolog 1Model Building of Antibody–Antigen Complex Structures Using GBSA ScoresFc‐Binding Antibody‐Recruiting Molecules Targeting Prostate‐Specific Membrane Antigen: Defucosylation of Antibody for Efficacy Improvement**Structure-based design and discovery of novel anti-tissue factor antibodies with cooperative double-point mutations, using interaction analysisAntibody Affinity Maturation by Computational DesignExploring designability of electrostatic complementarity at an antigen-antibody interface directed by mutagenesis, biophysical analysis, and molecular dynamics simulationsImproving the affinity of an antibody for its antigen via long-range electrostatic interactionsSeeking high-priority mutations enabling successful antibody-breeding: systematic analysis of a mutant that gained over 100-fold enhanced affinityMolecular Dynamics Simulation of the Antigen–Antibody Complex Formation Process between Hen Egg-White Lysozyme and HyHEL-10Computer-guided library generation applied to the optimization of single-domain antibodiesFc-binding antibody-recruiting molecules exploit endogenous antibodies for anti-tumor immune responsesSystematic classification of CDR‐L3 in antibodies: Implications of the light chain subtypes and the V<sub>L</sub>–V<sub>H</sub> interfaceExpression, Purification and Structural Analysis of Human IL-18 Binding Protein: A Potent Therapeutic Molecule for AllergyThermodynamics of antibody-antigen interaction revealed by mutation analysis of antibody variable regions
- 連携機関・データベース
- 国立情報学研究所 : CiNii Research
- 提供元機関・データベース
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