記事
α-Synuclein Locus Triplication Causes Parkinson's Disease
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CiNii Research
α-Synuclein Locus Triplication Causes Parkinson's Disease
- 資料種別
- 記事
- 著者
- A. B. Singletonほか
- 出版者
- American Association for the Advancement of Science (AAAS)
- 出版年
- 2003-10-31
- 資料形態
- デジタル
- 掲載誌名
- Science 302 5646
- 掲載ページ
- p.841-841
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デジタル
- 資料種別
- 記事
- 著者標目
- 出版年月日等
- 2003-10-31
- 出版年（W3CDTF）
- 2003-10-31
- タイトル（掲載誌）
- Science
- 巻号年月日等（掲載誌）
- 302 5646
- 掲載巻
- 302
- 掲載号
- 5646
- 掲載ページ
- 841-841
- 掲載年月日（W3CDTF）
- 2003-10-31
- ISSN（掲載誌）
- 00368075
- 出版事項（掲載誌）
- American Association for the Advancement of Science (AAAS)
- 対象利用者
- 一般
- DOI
- 10.1126/science.1090278
- 作成日（W3CDTF）
- 2003-10-31
- 参照
- Extracellular alpha-synuclein drives sphingosine 1-phosphate receptor subtype 1 out of lipid rafts, leading to impaired inhibitory G-protein signalingAnimal Model for Prodromal Parkinson’s DiseaseExtracellular alpha-synuclein induces sphingosine 1-phosphate receptor subtype 1 uncoupled from inhibitory G-protein leaving beta-arrestin signal intactImpairment of PDGF-induced chemotaxis by extracellular α-synuclein through selective inhibition of Rac1 activationTrehalose intake induces chaperone molecules along with autophagy in a mouse model of Lewy body diseaseAlpha-synuclein overexpression and aggregation exacerbates impairment of mitochondrial functions by augmenting oxidative stress in human neuroblastoma cellsFamilial Parkinson disease mutations influence α-synuclein assemblyPhosphorylation of α-Synuclein Protein at Ser-129 Reduces Neuronal Dysfunction by Lowering Its Membrane Binding Property in Caenorhabditis elegansFABP3 Protein Promotes α-Synuclein Oligomerization Associated with 1-Methyl-1,2,3,6-tetrahydropiridine-induced NeurotoxicityPseudo‐heterozygous rearrangement mutation of <i>parkin</i>Localization of MAP1-LC3 in Vulnerable Neurons and Lewy Bodies in Brains of Patients With Dementia With Lewy BodiesClipCrop: a tool for detecting structural variations with single-base resolution using soft-clipping informationBridging Molecular Genetics and Biomarkers in Lewy Body and Related DisordersAnimal Models for Parkinson’s Disease Research: Trends in the 2000sStructures of α-synuclein filaments from multiple system atrophyAlpha‐synuclein dynamics in induced pluripotent stem cell‐derived dopaminergic neurons from a Parkinson’s disease patient (<i>PARK4</i>) with <i>SNCA</i> triplicationParkinson's disease: Alterations in iron and redox biology as a key to unlock therapeutic strategiesProteomic analysis of subcellular compartments containing disseminated alpha-synuclein seedsCommon Marmoset Model of α-Synuclein Propagation<scp>α‐Synuclein V15A</scp> Variant in Familial Parkinson's Disease Exhibits a Weaker Lipid‐Binding PropertyPathological and physiological functional cross-talks of α-synuclein and tau in the central nervous systemPhosphorylation of α-synuclein at T64 results in distinct oligomers and exerts toxicity in models of Parkinson’s diseaseOverview of the Impact of Pathogenic LRRK2 Mutations in Parkinson’s DiseaseLoss of GBA in zebrafish leads to dopaminergic neurodegeneration, but overexpression of α-synuclein does not further worsen degenerationBrain region‐dependent differential expression of alpha‐synucleinPopulation‐specific frequencies for <i>LRRK2</i> susceptibility variants in the genetic epidemiology of Parkinson's disease (GEO‐PD) consortiumIncrease expression of α-synuclein in aged human brain associated with neuromelanin accumulationα-Synuclein BAC transgenic mice as a model for Parkinson's disease manifested decreased anxiety-like behavior and hyperlocomotionNeuroprotective Function of 14-3-3 Proteins in NeurodegenerationMitochondrial-Associated Membranes in Parkinson’s DiseaseGaucher-Associated ParkinsonismExpression of α-synuclein is regulated in a neuronal cell type-dependent mannerThe interplay of intrinsic disorder and macromolecular crowding on <i>α</i>-synuclein fibril formation<scp>p</scp>62 Deficiency Enhances α‐Synuclein Pathology in MiceDopamine-Mediated Oxidation of Methionine 127 in α-Synuclein Causes Cytotoxicity and Oligomerization of α-SynucleinAutophagy system as a potential therapeutic target for neurodegenerative diseasesTargeting of Lysosomal Pathway Genes for Parkinson's Disease Modification: Insights From Cellular and Animal ModelsDeciphering the prion-like behavior of pathogenic protein aggregates in neurodegenerative diseasesMeasurement of GCase Activity in Cultured CellsStructures of α-synuclein filaments from human brains with Lewy pathologyHost-to-graft propagation of inoculated α-synuclein into transplanted human induced pluripotent stem cell-derived midbrain dopaminergic neuronsDevelopment and validation of an expanded antibody toolset that captures alpha-synuclein pathological diversity in Lewy body diseasesAngiogenin variants in Parkinson disease and amyotrophic lateral sclerosisPropagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studiesThe Lewy Body in Parkinson’s Disease and Related Neurodegenerative DisordersSimple screening method for copy number variations associated with physical featuresNormalization of Overexpressed α-Synuclein Causing Parkinson's Disease By a Moderate Gene Silencing With RNA InterferenceA progressive dopaminergic phenotype associated with neurotoxic conversion of α-synuclein in BAC-transgenic ratsPhosphorylated α‐synuclein can be detected in blood plasma and is potentially a useful biomarker for Parkinson's diseaseTherapeutic effects of human mesenchymal and hematopoietic stem cells on rotenone‐treated parkinsonian micePrefoldin prevents aggregation of α-synucleinImmunohistochemical localization of apoptosome-related proteins in Lewy bodies in Parkinson׳s disease and dementia with Lewy bodiesAndrogen receptor inclusions acquire GRP78/BiP to ameliorate androgen-induced protein misfolding stress in embryonic stem cellsGenetic and clinical analysis in a Chinese parkinsonism-predominant spinocerebellar ataxia type 2 familyYY1 binds to α-synuclein 3′-flanking region SNP and stimulates antisense noncoding RNA expressionSerine 129 phosphorylation of membrane-associated α-synuclein modulates dopamine transporter function in a G protein–coupled receptor kinase–dependent mannerGBA haploinsufficiency accelerates alpha-synuclein pathology with altered lipid metabolism in a prodromal model of Parkinson’s diseaseBiomarkers for the diagnosis and management of Parkinson's diseaseα-Synuclein filaments from transgenic mouse and human synucleinopathy-containing brains are major seed-competent speciesLipids: Key Players That Modulate α-Synuclein Toxicity and Neurodegeneration in Parkinson’s DiseaseAnti-aggregation Effects of Phenolic Compounds on α-synucleinAssembly of α-synuclein and neurodegeneration in the central nervous system of heterozygous M83 mice following the peripheral administration of α-synuclein seedsRoles of α-Synuclein and Disease-Associated Factors in Drosophila Models of Parkinson’s DiseaseRapid Induction of Dopaminergic Neuron Loss Accompanied by Lewy Body-Like Inclusions in A53T BAC-SNCA Transgenic Miceα-Synuclein-mediated neurodegeneration in Dementia with Lewy bodies: the pathobiology of a paradoxDOPAnization of tyrosine in α-synuclein by tyrosine hydroxylase leads to the formation of oligomersStructures of tau and α-synuclein filaments from brains of patients with neurodegenerative diseasesUltrastructural and biochemical classification of pathogenic tau, α-synuclein and TDP-43Photo‐oxygenation of histidine residue inhibits α‐synuclein aggregationPathological role of lipid interaction with α-synuclein in Parkinson's diseasePrion-like spreading of pathological α-synuclein in brainPropagation of pathological α-synuclein in marmoset brainA case of α‐<i>synuclein</i> gene duplication presenting with head‐shaking movementsRole of genomics in translational research for Parkinson’s diseaseGenomic aspects of sporadic neurodegenerative diseases<i>In Vivo</i> Application of an RNAi Strategy for the Selective Suppression of a Mutant Alleleα-Synuclein: Experimental PathologyAntiandrogen Flutamide Protects Male Mice From Androgen-Dependent Toxicity in Three Models of Spinal Bulbar Muscular AtrophyCan parkin be a target for future treatment of Parkinson's disease?<i>α</i>-Synuclein Transgenic<i>Drosophila</i>As a Model of Parkinson's Disease and Related SynucleinopathiesFatty Acid-Binding Protein 3 Expression in the Brain and Skin in Human SynucleinopathiesRetrogradely transmitted α-synuclein is taken up by the endophilin-independent endocytosis in the C. elegans neural circuitSeeded assembly <i>in vitro</i> does not replicate the structures of α‐synuclein filaments from multiple system atrophyAstrocytes Protect Human Dopaminergic Neurons from α-Synuclein Accumulation and PropagationUnraveling the Complex Interplay between Alpha-Synuclein and Epigenetic ModificationClinical Manifestations and Molecular Backgrounds of Parkinson's Disease Regarding Genes Identified From Familial and Population StudiesNew SNCA mutation and structures of α-synuclein filaments from juvenile-onset synucleinopathyIdentifying inducers of BDNF gene expression from pharmacologically validated compounds; antipyretic drug dipyrone increases BDNF mRNA in neuronsFatty Acid Binding Protein 3 Enhances the Spreading and Toxicity of α-Synuclein in Mouse BrainGeneration of a human induced pluripotent stem cell line derived from a Parkinson's disease patient carrying SNCA duplicationLimited spread of pathology within the brainstem of α-synuclein BAC transgenic mice inoculated with preformed fibrils into the gastrointestinal tractPrion-like propagation of α-synuclein in neurodegenerative diseasesAmido-bridged nucleic acid (AmNA)-modified antisense oligonucleotides targeting α-synuclein as a novel therapy for Parkinson’s diseaseE46K mutant α-synuclein is more degradation resistant and exhibits greater toxic effects than wild-type α-synuclein in Drosophila models of Parkinson's diseaseLewy body disease and dementia with Lewy bodiesHighlighted paper selected by editor-in-chief: Parkinsonian rotenone mouse model: reevaluation of long-term administration of rotenone in C57BL/6 miceTherapeutic Application of Stem Cell Technology toward the Treatment of Parkinson’s DiseaseCytoprotective effect of chlorogenic acid against a-synuclein-related toxicity in catecholaminergic PC12 cellsModification of α-synuclein by lipid peroxidation products derived from polyunsaturated fatty acids promotes toxic oligomerization: its relevance to Parkinson diseaseシンポジウム７‐２ パーキンソン病の病因・診断・治療研究の進歩 孤発性パーキンソン病の病因：リスク遺伝子と環境因子II．遺伝子研究の発展とParkinson病の病因Does Proteosome Inhibition Decrease or Accelerate Toxin-Induced Dopaminergic Neurodegeneration?3）αシヌクレインヒト幹細胞由来神経細胞を用いた神経回路形成と機能再生
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