A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of High-Dose Rebamipide Treatment for Low-Dose Aspirin-Induced Moderate-to-Severe Small Intestinal Damage

• 資料種別: 記事
• タイトル: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of High-Dose Rebamipide Treatment for Low-Dose Aspirin-Induced Moderate-to-Severe Small Intestinal Damage
• 著者標目: Toshio Watanabe; Toshihisa Takeuchi; Osamu Handa; https://orcid.org/0000-0003-2228-0405; Yasuhisa Sakata; Tetsuya Tanigawa; Masatsugu Shiba; Yuji Naito; Kazuhide Higuchi; Kazuma Fujimoto; Toshikazu Yoshikawa; Tetsuo Arakawa
• 出版年月日等: 2015-04-15
• 出版年（W3CDTF）: 2015-04-15
• 寄与者: John Green
• タイトル（掲載誌）: PLOS ONE
• 巻号年月日等（掲載誌）: 10 4
• 掲載巻: 10
• 掲載号: 4
• 掲載ページ: e0122330-
• 掲載年月日（W3CDTF）: 2015-04-15
• 出版事項（掲載誌）: Public Library of Science (PLoS)
• 件名標目: Male; Science; Quinolones; Capsule Endoscopy; Severity of Illness Index; Drug Administration Schedule; Double-Blind Method; Intestine, Small; Humans; Aged; Alanine; Aspirin; Dose-Response Relationship, Drug; Q; R; Anti-Ulcer Agents; Intestinal Diseases; Treatment Outcome; Medicine; Female; Research Article
• 対象利用者: 一般
• 標準番号（その他）: PMID : 25874951
• DOI: 10.1371/journal.pone.0122330
• 作成日（W3CDTF）: 2015-04-15
• オンライン閲覧公開範囲: インターネット公開
• 著作権情報: http://creativecommons.org/licenses/by/4.0/
• 関連情報（URI）: http://dx.plos.org/10.1371/journal.pone.0122330
• 参照: Mucus reduction promotes acetyl salicylic acid-induced small intestinal mucosal injury in rats; https://cir.nii.ac.jp/crid/1360285706978817664; Protective Effect of Irsogladine against Aspirin-Induced Mucosal Injury in Human Induced Pluripotent Stem Cell-Derived Small Intestine; https://cir.nii.ac.jp/crid/1360861705601667968; Preventive effect of ecabet sodium on low-dose aspirin-induced small intestinal mucosal injury: a randomized, double-blind, pilot study; https://cir.nii.ac.jp/crid/1361975846707686144; Determination of the adequate dosage of rebamipide, a gastric mucoprotective drug, to prevent low-dose aspirin-induced gastrointestinal mucosal injury; https://cir.nii.ac.jp/crid/1390282679650485120; Does discontinuation of antithrombotics affect the diagnostic yield of small bowel capsule endoscopy in patients demonstrating obscure gastrointestinal bleeding?; https://cir.nii.ac.jp/crid/1390282763041389056; 薬剤と小腸粘膜障害，小腸出血との関連：多施設カプセル内視鏡研究; https://cir.nii.ac.jp/crid/1390845713022809728
• 連携機関・データベース: 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/
• 提供元機関・データベース: Crossref; https://www.crossref.org

• 要約等: Low-dose aspirin (LDA) frequently causes small bowel injury. While some drugs have been reported to be effective in treating LDA-induced small intesti...