Autologous Bone Marrow-Derived Mononuclear Cell Therapy Prevents the Damage of Viable Myocardium and Improves Rat Heart Function Following Acute Anterior Myocardial Infarction
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- 資料種別
- 記事
- 著者標目
- 出版年月日等
- 2008
- 出版年（W3CDTF）
- 2008
- タイトル（掲載誌）
- Circulation Journal
- 巻号年月日等（掲載誌）
- 72 8
- 掲載巻
- 72
- 掲載号
- 8
- 掲載ページ
- 1336-1345
- 掲載年月日（W3CDTF）
- 2008
- ISSN（掲載誌）
- 13469843
- ISSN-L（掲載誌）
- 13469843
- 出版事項（掲載誌）
- The Japanese Circulation Society
- 本文の言語コード
- en
- 件名標目
- 対象利用者
- 一般
- 標準番号（その他）
- COI : 1:CAS:528:DC%2BD1cXhtVajtrvMPMID : 18654023
- DOI
- 10.1253/circj.72.1336
- 関連情報（URI）
- 参照
- Antioxidant, EUK-8, Prevents Murine Dilated CardiomyopathyTongue Muscle-Derived Stem Cells Express Connexin 43 and Improve Cardiac Remodeling and Survival After Myocardial Infarction in MicePrompt Bone Marrow-Derived Mesenchymal Stem Cell Therapy Enables Early Porcine Heart Function Recovery from Acute Myocardial InfarctionSix-Month Angiographic Study of Immediate Autologous Bone Marrow Mononuclear Cell Implantation on Acute Anterior Wall Myocardial Infarction Using a Mini-Pig ModelGap Junctions Mediate the Spread of Ischemia-Reperfusion InjuryMechanisms of Remodelling A Question of Life (Stem Cell Production) and Death (Myocyte Apoptosis)Ischemia Enhances Translocation of Connexin43 and Gap Junction Intercellular Communication, Thereby Propagating Contraction Band Necrosis After ReperfusionEffects of Autologous Bone Marrow Mononuclear Cells Implantation in Canine Model of Pulmonary HypertensionImprovement of Cardiac Function by Intracoronary Freshly Isolated Bone Marrow Cells Transplantation in Patients With Acute Myocardial InfarctionRole of Endostatin in Cardiovascular RemodelingInhibition of Endostatin/Collagen XVIII Deteriorates Left Ventricular Remodeling and Heart Failure in Rat Myocardial Infarction Model
- 参照
- Stress Pathways and Heart FailureMyocardial homing and neovascularization by human bone marrow angioblasts is regulated by IL-8/Gro CXC chemokinesAccelerated Onset and Increased Incidence of Ventricular Arrhythmias Induced by Ischemia in Cx43-Deficient MiceCytotoxic T Lymphocytes Are Activated Following Myocardial Infarction and Can Recognize and Kill Healthy Myocytes In VitroRecommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements.Repair of Infarcted Myocardium by Autologous Intracoronary Mononuclear Bone Marrow Cell Transplantation in HumansQuantitative two-dimensional echocardiographic measurements are major predictors of adverse cardiovascular events after acute myocardial infarction. The protective effects of captopril.The coronary delivery of marrow stromal cells for myocardial regeneration: Pathophysiologic and therapeutic implicationsHuman Mesenchymal Stem Cells Differentiate to a Cardiomyocyte Phenotype in the Adult Murine HeartActivated neutrophils induce prolonged DNA damage in neighboring cellsCardiomyocytes can be generated from marrow stromal cells in vitroAllogeneic Mesenchymal Stem Cell Transplantation in Postinfarcted Rat MyocardiumAngiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantationChamber-related Differences in Connexin Expression in the Human HeartRETRACTED ARTICLE: Pluripotency of mesenchymal stem cells derived from adult marrowSerial echocardiographic assessment of left ventricular geometry and function after large myocardial infarction in the rat.Immunocytochemical analysis of connexin expression in the healthy and diseased cardiovascular systemDesmopressin and blood loss after cardiac surgeryTransplantation of Mesenchymal Stem Cells Improves Cardiac Function in a Rat Model of Dilated CardiomyopathyThe Gap Junction Communication ChannelProgrammed Cell Death and the Control of Cell Survival: Lessons from the Nervous SystemClinical Implications of Apoptosis in Ischemic MyocardiumCell Death During Development of the Nervous SystemRegeneration of ischemic cardiac muscle and vascular endothelium by adult stem cellsChimerism of the Transplanted HeartConnexins and Impulse Propagation in the Mouse HeartMesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted heartsReduced cardiac conduction velocity and predisposition to arrhythmias in connexin40-deficient miceDistal Microcirculatory Protection During Percutaneous Coronary Intervention in Acute ST-Segment Elevation Myocardial Infarction<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>Upregulation of Connexin43 Gap Junctions Between Smooth Muscle Cells After Balloon Catheter Injury in the Rat Carotid ArteryValsartan, Captopril, or Both in Myocardial Infarction Complicated by Heart Failure, Left Ventricular Dysfunction, or BothShock Wave Therapy Applied to Rat Bone Marrow-Derived Mononuclear Cells Enhances Formation of Cells Stained Positive for CD31 and Vascular Endothelial Growth FactorSafety and Efficacy of Autologous Progenitor Cell Transplantation for Therapeutic Angiogenesis in Patients With Critical Limb IschemiaAutologous bone marrow mononuclear cell implantation induces angiogenesis and bone formation in a patient with compartment syndrome.In Vitro Assessment of the Effect of Interleukin-1.BETA. on Angiogenic Potential of Bone Marrow Cells
- 連携機関・データベース
- 国立情報学研究所 : CiNii Research
- 提供元機関・データベース
- Japan Link CenterCrossrefPubMedCiNii ArticlesCrossrefCrossrefCrossrefCrossrefCrossrefCrossrefCrossrefCrossrefCrossrefCrossrefCrossref
- NII論文ID
- 110006835738
- 要約等
- <b>Background</b> We examined the effects of bone marrow-derived mononuclear cells (BMDMNCs) on preventing viable myocardium damage from myocardial infarction (MI) in a rat MI model. <b>Methods and Results</b> Saline (group 1) or BMDMNCs (group 2) were implanted into the infarct area (IA) of 1-week-old anterior wall MI Sprague - Dawley (SD) rats. Twenty SD rats without MI served as the controls (group 3). The results demonstrated that in remote viable myocardium, the integrated area (μm<sup>2</sup>) of connexin43 spots was lower, whereas the number of apoptotic nuclei were higher in group 1 than in groups 2 and 3 on day 90 following BMDMNC implantation (all p<0.001). Additionally, the number of vessels and survival myocardium in the IA was lower in group 1 than in groups 2 and 3 (all p<0.005). Furthermore, the mRNA expressions of nitric oxide synthase, interleukin-8/Gro-α, interleukin-10 and matrix metalloproteinase-9 were higher in group 2 than in groups 1 and 3 in peri-IA (all p<0.05). On days 42 and 90, the left ventricular (LV) function was lower in group 1 than in groups 2 and 3 (p<0.001). <b>Conclusions</b> Autologous BMDMNC therapy improves LV function, and mitigates molecular and cellular perturbation following MI. (<i>Circ J</i> 2008; <b>72:</b> 1336 - 1345)<br>
- DOI
- 10.1253/circj.72.1336
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