Deglycosylated Ginsenosides Are More Potent Inducers of CYP1A1, CYP1A2 and CYP3A4 Expression in HepG2 Cells than Glycosylated Ginsenosides

• 資料種別: 記事
• タイトル: Deglycosylated Ginsenosides Are More Potent Inducers of CYP1A1, CYP1A2 and CYP3A4 Expression in HepG2 Cells than Glycosylated Ginsenosides
• 著者標目: HAO Miao; YIN Jun; LI Jingquan; ZHAO Yuqing; WANG Hui; BA Qian
• 出版年月日等: 2011
• 出版年（W3CDTF）: 2011
• タイトル（掲載誌）: Ｄｒｕｇ Ｍｅｔａｂｏｌｉｓｍ ａｎｄ Ｐｈａｒｍａｃｏｋｉｎｅｔｉｃｓ
• 巻号年月日等（掲載誌）: 26 2
• 掲載巻: 26
• 掲載号: 2
• 掲載ページ: 201-205
• 掲載年月日（W3CDTF）: 2011
• ISSN（掲載誌）: 13474367
• 出版事項（掲載誌）: The Japanese Society for the Study of Xenobiotics
• 本文の言語コード: en
• 件名標目: ginseng; drug interactions; P450; induction; HepG2
• 対象利用者: 一般
• 標準番号（その他）: COI : 1:CAS:528:DC%2BC3MXpvVyjurg%3D; PMID : 21178302
• DOI: 10.2133/dmpk.dmpk-10-nt-056; https://doi.org/10.2133/dmpk.dmpk-10-nt-056
• 関連情報（URI）: http://api.elsevier.com/content/article/PII:S1347436715306613?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S1347436715306613?httpAccept=text/plain; https://search.jamas.or.jp/link/ui/2012093359
• 参照: Increased Levels of Fatty Acids Contributed to Induction of Hepatic CYP3A4 Activity Induced by Diabetes : In Vitro Evidence From HepG2 Cell and Fa2N-4 Cell Lines; https://cir.nii.ac.jp/crid/1390001205178532864
• 参照: 20(S)-25-methoxyl-dammarane-3β, 12β, 20-triol, a novel natural product for prostate cancer therapy: activity in vitro and in vivo and mechanisms of action; https://cir.nii.ac.jp/crid/1360011145535530112; Analysis methods of ginsenosides; https://cir.nii.ac.jp/crid/1360011145955875968; In Vitro Inhibition and Induction of Human Hepatic Cytochrome P450 Enzymes by Modafinil; https://cir.nii.ac.jp/crid/1360022501514324352; Induction of cytochrome P450 1A1 expression by ginsenoside Rg1 and Rb1 in HepG2 cells; https://cir.nii.ac.jp/crid/1360292620101927296; Human Cytochrome P-450 3A4: In Vitro Drug-Drug Interaction Patterns Are Substrate-Dependent; https://cir.nii.ac.jp/crid/1360303271539984768; Ginsenoside Metabolites, Rather Than Naturally Occurring Ginsenosides, Lead to Inhibition of Human Cytochrome P450 Enzymes; https://cir.nii.ac.jp/crid/1360574095042095488; Ginseng pharmacology; https://cir.nii.ac.jp/crid/1360855569771448448; Experimental therapy of prostate cancer with novel natural product anti‐cancer ginsenosides; https://cir.nii.ac.jp/crid/1361137044800299264; Interactions of Herbs with Cytochrome P450; https://cir.nii.ac.jp/crid/1361137045712947840; Herbal Interactions Involving Cytochrome P450 Enzymes; https://cir.nii.ac.jp/crid/1361137046251891968; The Inhibitory Effects of Herbal Components on CYP2C9 and CYP3A4 Catalytic Activities in Human Liver Microsomes; https://cir.nii.ac.jp/crid/1361699993808173184; Panax ginseng; https://cir.nii.ac.jp/crid/1361699996216608256; Cytochrome P450 enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells; https://cir.nii.ac.jp/crid/1361981468439829248; CYP1A Induction and Human Risk Assessment: An Evolving Tale of in Vitro and in Vivo Studies; https://cir.nii.ac.jp/crid/1361981470677696640; Novel ginsenosides 25-OH-PPD and 25-OCH 3 -PPD as experimental therapy for pancreatic cancer: anticancer activity and mechanisms of action; https://cir.nii.ac.jp/crid/1362262944063397632; Regulation of CYP3A4 Expression in Human Hepatocytes by Pharmaceuticals and Natural Products; https://cir.nii.ac.jp/crid/1362262945337534848; IN VITRO AND IN VIVO DRUG INTERACTIONS INVOLVING HUMAN CYP3A; https://cir.nii.ac.jp/crid/1362544419299987072; Variability in commercial ginseng products: an analysis of 25 preparations; https://cir.nii.ac.jp/crid/1362544419565526144; Cytochrome P450: What Have We Learned and What Are the Future Issues?; https://cir.nii.ac.jp/crid/1362544420526950400; Regulation of CYP1A1 by heavy metals and consequences for drug metabolism; https://cir.nii.ac.jp/crid/1362825893895364480; Herb-drug interactions; https://cir.nii.ac.jp/crid/1362825894571493504; Clinical importance of the cytochromes P450; https://cir.nii.ac.jp/crid/1362825895469435136; Determination of 25-OH-PPD in rat plasma by high-performance liquid chromatography–mass spectrometry and its application in rat pharmacokinetic studies; https://cir.nii.ac.jp/crid/1363107368765433984; Effects of ginseng components on c-DNA-expressed cytochrome P450 enzyme catalytic activity; https://cir.nii.ac.jp/crid/1363107371305551744; Pharmacokinetics and bioavailability of ginsenoside Rb1 and Rg1 from Panax notoginseng in rats; https://cir.nii.ac.jp/crid/1363670321212047232; Structure-Activity Relationship and Substrate-Dependent Phenomena in Effects of Ginsenosides on Activities of Drug-Metabolizing P450 Enzymes; https://cir.nii.ac.jp/crid/1363951794213618176; In vitro anti-cancer activity and structure–activity relationships of natural products isolated from fruits of Panax ginseng; https://cir.nii.ac.jp/crid/1364233269040195968; EFFECTS OF INDIVIDUAL GINSENOSIDES, GINKGOLIDES AND FLAVONOIDS ON CYP2C19 AND CYP2D6 ACTIVITY IN HUMAN LIVER MICROSOMES; https://cir.nii.ac.jp/crid/1364233269189278592; Cytochrome P450 phenotypic ratios for predicting herb‐drug interactions in humans; https://cir.nii.ac.jp/crid/1364233269257379712; In Vitro Effect of Standardized Ginseng Extracts and Individual Ginsenosides on the Catalytic Activity of Human CYP1A1, CYP1A2, and CYP1B1; https://cir.nii.ac.jp/crid/1364233269733264128; Cancer prevention and therapeutics: Panax ginseng; https://cir.nii.ac.jp/crid/1371414294793017477; Metabolism and pharmacokinetics of ginsenosides; https://cir.nii.ac.jp/crid/1371414294793017479; The Inhibitory Effect of Intestinal Bacterial Metabolite of Ginsenosides on CYP3A Activity; https://cir.nii.ac.jp/crid/1390282679601432064; Metabolic Activation of Ginsenoside: Deglycosylation by Intestinal Bacteria and Esterification With Fatty Acid; https://cir.nii.ac.jp/crid/1390282680154199680
• 連携機関・データベース: 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/
• 提供元機関・データベース: Japan Link Center; https://japanlinkcenter.org/top; Crossref; https://www.crossref.org; PubMed; https://pubmed.ncbi.nlm.nih.gov; CiNii Articles
• NII論文ID: 130004463178

• 要約等: Ginseng is one of the most commonly used herbal medicines worldwide. Ginsenosides are believed to be responsible for the therapeutic activities of gin...