SUMOylation attenuates the aggregation propensity and cellular toxicity of the polyglutamine expanded ataxin-7

• 資料種別: 記事
• タイトル: SUMOylation attenuates the aggregation propensity and cellular toxicity of the polyglutamine expanded ataxin-7
• 著者標目: Janer, Alexandre; Werner, Andreas; Takahashi-Fujigasaki, Junko; Daret, Aurélie; Fujigasaki, Hiroto; Takada, Koji; Duyckaerts, Charles; Brice, Alexis; Dejean, Anne; Sittler, Annie
• 出版年月日等: 2009-10-19
• 出版年（W3CDTF）: 2009-10-19
• 寄与者: Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière (CRICM) ; Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS); Organisation Nucléaire et Oncogenèse ; Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM); The Jikei University School of Medicine; Japanese Red Cross Musashino Hospital [Tokyo]; CHU Pitié-Salpêtrière [AP-HP] ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU); This study was funded by EuroSCA European consortium (contract number: LSHM-CT-2004-503304/E04004DD), Verum Foundation and La Ligue contre le Cancer (Equipe Labellisée). We thank the patient's association “Connaitre les Syndromes Cerebelleux” for a fellowship to A.J. and a grant to A.S. A.J. was supported by the French Ministry of Research and the Academie Nationale de Médecine, A.W. by the Fondation Recherche Medicale. J.T.F. was supported by Grant-in-Aid for Young Scientist (A) from the Japanese Ministry of Education, Science and Culture.; European Project: SFRH/BPD/34460/2006,FCT::Pós-Doutoramento,SFRH/2006,SFRH/BPD/34460/2006(2007); Cheriet Rauline, Samia; Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière (CRICM) ; Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC); Organisation Nucléaire et Oncogenèse ; Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM); Service de Neuropathologie [CHU Pitié Salpêtrière] ; CHU Pitié-Salpêtrière [AP-HP] ; Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); Service de Génétique Cytogénétique et Embryologie [CHU Pitié-Salpêtrière] ; CHU Pitié-Salpêtrière [AP-HP] ; Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
• タイトル（掲載誌）: Human Molecular Genetics
• 巻号年月日等（掲載誌）: 19
• 掲載巻: 19
• 掲載ページ: 181-195
• 掲載年月日（W3CDTF）: 2009-10-19
• ISSN（掲載誌）: 09646906
• 出版事項（掲載誌）: Oxford University Press (OUP)
• 件名標目: Male; MESH: Fatal Outcome; MESH: Protein Structure, Quaternary; [SDV]Life Sciences [q-bio]; Intranuclear Inclusion Bodies; MESH: Neurons; Mice; Fatal Outcome; MESH: Child; MESH: Caspase 3; MESH: Trinucleotide Repeat Expansion; MESH: Animals; MESH: Nerve Tissue Proteins; Child; Neurons; MESH: Peptides; Caspase 3; MESH: Proteasome Endopeptidase Complex; [SDV] Life Sciences [q-bio]; Protein Transport; MESH: Ataxin-7; Small Ubiquitin-Related Modifier Proteins; Female; Protein Binding; Subcellular Fractions; Adult; MESH: Protein Transport; MESH: Enzyme Activation; Proteasome Endopeptidase Complex; MESH: Ubiquitin; MESH: Spinocerebellar Ataxias; Nerve Tissue Proteins; MESH: Protein Binding; Animals; Humans; Spinocerebellar Ataxias; MESH: Lysine; Protein Structure, Quaternary; MESH: Mice; Ataxin-7; MESH: Intranuclear Inclusion Bodies; MESH: Humans; Ubiquitin; Lysine; MESH: Adult; MESH: Multiprotein Complexes; MESH: Male; Enzyme Activation; MESH: Small Ubiquitin-Related Modifier Proteins; MESH: Subcellular Fractions; Multiprotein Complexes; Peptides; Trinucleotide Repeat Expansion; MESH: Female
• 対象利用者: 一般
• 標準番号（その他）: PMID : 19843541
• DOI: 10.1093/hmg/ddp478; https://doi.org/10.1093/hmg/ddp478
• オンライン閲覧公開範囲: インターネット公開
• 連携機関・データベース: 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/

• 要約等: Post-translational modification by SUMO (small ubiquitin-like modifier) was proposed to modulate the pathogenesis of several neurodegenerative disease...