シクロデキストリンを用いた人工ヘモグロビンの開発およびガス中毒解毒薬への応用 (解説小特集 環状糖類,シクロデキストリンと歩む未来)
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- Material Type
- 記事
- Author/Editor
- 北岸 宏亮
- Series Title
- Author Heading
- Alternative Title
- Cyclodextrin-based Development of Artificial Hemoglobin and Its Use for Antidote Against Gas Poisoning
- Periodical title
- 粉体工学会誌 = Journal of the Society of Powder Technology, Japan / 粉体工学会 編
- No. or year of volume/issue
- 63(5)=684:2026
- Volume
- 63
- Issue
- 5
- Sequential issue number
- 684
- Pages
- 187-193
- Publication date of volume/issue (W3CDTF)
- 2026
- ISSN (Periodical Title)
- 0386-6157
- ISSN-L (Periodical Title)
- 0386-6157
- Publication (Periodical Title)
- 京都 : 粉体工学会
- Place of Publication (Country Code)
- JP
- Text Language Code
- jpn
- NDLC
- Target Audience
- 一般
- Holding library
- 国立国会図書館
- Call No.
- Z17-38
- Data Provider (Database)
- 国立国会図書館 : 国立国会図書館雑誌記事索引
- Bibliographic ID (NDL)
- 034741329
- Bibliographic Record Category (NDL)
- 632
- Summary, etc.
- <p>Cyclodextrin functions as a host molecule that can include external guest molecules in its hydrophobic cavity in water. In our laboratory, we have found that per-<i>O</i>-methylated β-cyclodextrin (TMe-β-CD) forms a stable 2:1 inclusion complex with 5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrin (TPPS). The inclusion complex has a strong hydrophobic cavity around the porphyrin scaffold, similar to the environment of heme in heme proteins. We have synthesized a per-<i>O</i>-methylated β-CD dimer having pyridine linker (Py3CD) to make a biomimetic model compound of hemoglobin (Hb) and myoglobin (Mb). The inclusion complex of Py3CD with iron complex of TPPS (FeTPPS) is the first biomimetic Hb/Mb model complex in water. The complex, hemoCD, showed a very high CO binding affinity <i>in vivo</i>. When hemoCD was injected to animals (mice and rats) after exposure to CO, hemoCD captured CO during circulation and was excreted in urine without showing any toxic effect. These properties seem appropriate for the use of hemoCD as an injectable antidote against CO poisoning. We have just started the drug development to implement hemoCD as a CO antidote for clinical use.</p>
- DOI
- 10.4164/sptj.63.187
- Access Restrictions
- インターネット公開
- Data Provider (Database)
- 科学技術振興機構 : J-STAGE
- Summary, etc.
- <p>Cyclodextrin functions as a host molecule that can include external guest molecules in its hydrophobic cavity in water. In our laboratory, we have found that per-<i>O</i>-methylated β-cyclodextrin (TMe-β-CD) forms a stable 2:1 inclusion complex with 5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrin (TPPS). The inclusion complex has a strong hydrophobic cavity around the porphyrin scaffold, similar to the environment of heme in heme proteins. We have synthesized a per-<i>O</i>-methylated β-CD dimer having pyridine linker (Py3CD) to make a biomimetic model compound of hemoglobin (Hb) and myoglobin (Mb). The inclusion complex of Py3CD with iron complex of TPPS (FeTPPS) is the first biomimetic Hb/Mb model complex in water. The complex, hemoCD, showed a very high CO binding affinity <i>in vivo</i>. When hemoCD was injected to animals (mice and rats) after exposure to CO, hemoCD captured CO during circulation and was excreted in urine without showing any toxic effect. These properties seem appropriate for the use of hemoCD as an injectable antidote against CO poisoning. We have just started the drug development to implement hemoCD as a CO antidote for clinical use.</p>
- DOI
- 10.4164/sptj.63.187
- Related Material (URI)
- References
- Nitric Oxide Binding to Ferric and Ferrous Porphyrins Encapsulated in the Cyclodextrin Nanocavities in Aqueous SolutionDetoxification of hydrogen sulfide by synthetic heme model compoundsA synthetic porphyrin as an effective dual antidote against carbon monoxide and cyanide poisoningSensitive quantification of carbon monoxide in vivo reveals a protective role of circulating hemoglobin in CO intoxicationCircadian clock disruption by selective removal of endogenous carbon monoxideDetection and Removal of Endogenous Carbon Monoxide by Selective and Cell-Permeable Hemoprotein Model ComplexesFeedback Response to Selective Depletion of Endogenous Carbon Monoxide in the BloodA Diatomic Molecule Receptor That Removes CO in a Living OrganismIron Porphyrin−Cyclodextrin Supramolecular Complex as a Functional Model of Myoglobin in Aqueous SolutionDioxygen Binding to a Simple Myoglobin Model in Aqueous SolutionFunctional Analogues of Cytochrome <i>c</i> Oxidase, Myoglobin, and HemoglobinThe Molecular Mechanism of Autoxidation for Myoglobin and Hemoglobin: A Venerable PuzzleTetraarylporphyrins as Probes for Studying Mechanism of Inclusion-complex Formation of Cyclodextrins. Effect of Microscopic Environment on Inclusion of Ionic GuestsPolymerized liposome/lipid Heme as an oxygen transporter under physiological conditions
- Data Provider (Database)
- 国立情報学研究所 : CiNii Research
- Original Data Provider (Database)
- Japan Link Center雑誌記事索引データベースCrossref
- Bibliographic ID (NDL)
- 034741329