医薬品原薬としてのシクロデキストリン : 創薬基盤技術としての新展開 (解説小特集 環状糖類,シクロデキストリンと歩む未来)
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- Material Type
- 記事
- Author/Editor
- 本山 敬一
- Series Title
- Author Heading
- Alternative Title
- Cyclodextrins as Active Pharmaceutical Ingredients : New Developments as a Platform Technology for Drug Discovery
- Periodical title
- 粉体工学会誌 = Journal of the Society of Powder Technology, Japan / 粉体工学会 編
- No. or year of volume/issue
- 63(5)=684:2026
- Volume
- 63
- Issue
- 5
- Sequential issue number
- 684
- Pages
- 194-199
- Publication date of volume/issue (W3CDTF)
- 2026
- ISSN (Periodical Title)
- 0386-6157
- ISSN-L (Periodical Title)
- 0386-6157
- Publication (Periodical Title)
- 京都 : 粉体工学会
- Place of Publication (Country Code)
- JP
- Text Language Code
- jpn
- Subject Heading
- NDLC
- Target Audience
- 一般
- Holding library
- 国立国会図書館
- Call No.
- Z17-38
- Data Provider (Database)
- 国立国会図書館 : 国立国会図書館雑誌記事索引
- Bibliographic ID (NDL)
- 034741333
- Bibliographic Record Category (NDL)
- 632
- Summary, etc.
- <p>Cyclodextrins (CDs) have long been recognized as indispensable molecular scaffolds in the pharmaceutical and biomedical sciences, owing to their capacity to enhance the solubility and stability of hydrophobic compounds. Our laboratory has systematically advanced the application of CDs as enabling technologies in drug development. In particular, our research has encompassed the formulation of poorly water-soluble agents, the stabilization of labile pharmaceuticals, the development of targeted delivery carriers, and the rational design of novel CD derivatives for the modulation of pharmacokinetic behavior. Furthermore, CD-based drug delivery platforms have demonstrated considerable promise in addressing therapeutic areas characterized by substantial unmet medical needs, such as oncology and neurological disorders. Recently, translational research has extended toward the direct utilization of CDs as active pharmaceutical ingredients. In this paper, we will provide a comprehensive account of our research endeavors and delineate future perspectives on the contribution of CD science to innovative drug discovery and development.</p>
- DOI
- 10.4164/sptj.63.194
- Access Restrictions
- インターネット公開
- Data Provider (Database)
- 科学技術振興機構 : J-STAGE
- Summary, etc.
- <p>Cyclodextrins (CDs) have long been recognized as indispensable molecular scaffolds in the pharmaceutical and biomedical sciences, owing to their capacity to enhance the solubility and stability of hydrophobic compounds. Our laboratory has systematically advanced the application of CDs as enabling technologies in drug development. In particular, our research has encompassed the formulation of poorly water-soluble agents, the stabilization of labile pharmaceuticals, the development of targeted delivery carriers, and the rational design of novel CD derivatives for the modulation of pharmacokinetic behavior. Furthermore, CD-based drug delivery platforms have demonstrated considerable promise in addressing therapeutic areas characterized by substantial unmet medical needs, such as oncology and neurological disorders. Recently, translational research has extended toward the direct utilization of CDs as active pharmaceutical ingredients. In this paper, we will provide a comprehensive account of our research endeavors and delineate future perspectives on the contribution of CD science to innovative drug discovery and development.</p>
- DOI
- 10.4164/sptj.63.194
- Related Material (URI)
- References
- A water-soluble β-cyclodextrin polymer reduces cholesterol accumulation and autophagy dysfunction in vitro and in Niemann-Pick type C disease model miceTargeting envelope lipids with 2,6‑di‑ <i>O</i> ‑methyl‑3‑acetyl‑β‑cyclodextrin impairs infectivity of SARS‑CoV‑2 and Japanese encephalitis virusMannose-methyl-β-cyclodextrin suppresses tumor growth by targeting both colon cancer cells and tumor-associated macrophagesシクロデキストンを基盤としたマテリアルの創製と医薬への応用Lactose-Appended Hydroxypropyl-β-Cyclodextrin Lowers Cholesterol Accumulation and Alleviates Motor Dysfunction in Niemann–Pick Type C Disease Model MiceFolic Acid-Appended Hydroxypropyl-β-Cyclodextrin Exhibits Potent Antitumor Activity in Chronic Myeloid Leukemia Cells via Autophagic Cell DeathLactose-appended β-cyclodextrin as an effective nanocarrier for brain deliveryIn vivo Efficacy and Safety Evaluation of Lactosyl-β-cyclodextrin as a Therapeutic Agent for Hepatomegaly in Niemann-Pick Type C DiseaseDAMP-Inducing Adjuvant and PAMP Adjuvants Parallelly Enhance Protective Type-2 and Type-1 Immune Responses to Influenza Split VaccinationReply: Lung toxicity of hydroxyl-β-cyclodextrin infusionPotential use of Folate-appended Methyl-β-Cyclodextrin as an Anticancer AgentEffects of cyclodextrin in two patients with Niemann–Pick Type C diseasePotential use of glucuronylglucosyl-β-cyclodextrin as a novel therapeutic tool for familial amyloidotic polyneuropathyReduced Glutathione Enhances Fertility of Frozen/Thawed C57BL/6 Mouse Sperm after Exposure to Methyl-Beta-Cyclodextrin1Cyclodextrin, a novel therapeutic tool for suppressing amyloidogenic transthyretin misfolding in transthyretin-related amyloidosisEffect of cyclodextrins on transthyretin amyloid formation in transthyretin-related amyloidosisDesign and evaluation of folate-appended methyl-β-cyclodextrin as a new antitumor agent2-Hydroxypropyl-β-Cyclodextrin Raises Hearing Threshold in Normal Cats and in Cats With Niemann-Pick Type C DiseaseCombination medium of cryoprotective agents containing <scp>l</scp>-glutamine and methyl-<i>β</i>-cyclodextrin in a preincubation medium yields a high fertilization rate for cryopreserved C57BL/6J mouse spermInvolvement of PI3K-Akt-Bad pathway in apoptosis induced by 2,6-di-O-methyl-β-cyclodextrin, not 2,6-di-O-methyl-α-cyclodextrin, through cholesterol depletion from lipid rafts on plasma membranes in cellsSugammadex: the first selective binding reversal agent for neuromuscular blockMethyl-Beta-Cyclodextrin Improves Fertilizing Ability of C57BL/6 Mouse Sperm after Freezing and Thawing by Facilitating Cholesterol Efflux from the Cells1Inhibitory effects of dimethylacetyl-β-cyclodextrin on lipopolysaccharide-induced macrophage activation and endotoxin shock in miceDesign and evaluation of cyclodextrin-based drug formulaitonInhibitory Effects of Novel Hydrophilic Cyclodextrin Derivatives on Nitric Oxide Production in Macrophages Stimulated with LipopolysaccharideHeptakis(2,6‐di‐O‐methyl‐3‐O‐acetyl)‐β‐cyclodextrin: A Water‐Soluble cyclodextrin derivative with low hemolytic activityAntiproliferative effect of methyl-β-cyclodextrin in vitro and in human tumour xenografted athymic nude miceCyclodextrin Drug Carrier Systems
- Data Provider (Database)
- 国立情報学研究所 : CiNii Research
- Original Data Provider (Database)
- Japan Link Center雑誌記事索引データベースCrossref
- Bibliographic ID (NDL)
- 034741333