原発性胆汁性肝硬変における自己胆管上皮細胞に対するひ臓由来の細胞傷害性Ｔ細胞活性の測定

Material type: 記事

Author: 中田収作ほか

Publisher: The Japan Society of Hepatology

Publication date: 1991

Material Format: Digital

Journal name: 肝臓 32 6

Publication Page: p.596-603

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Summary, etc.：: 原発性胆汁性肝硬変(PBC)患者の脾臓リンパ球の自己胆管上皮細胞に対する細胞傷害活性を測定する系を確立し,胆管上皮細胞の傷害機序を検討した.PBC 3症例の脾臓リンパ球は自己胆管上皮細胞に対して全例が細胞傷害活性を示したが,対照疾患6症例は全例細胞傷害活性を示さなかった.細胞傷害活性はT細胞分画に検...

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Material Type: 記事
Title: 原発性胆汁性肝硬変における自己胆管上皮細胞に対するひ臓由来の細胞傷害性Ｔ細胞活性の測定
Author Heading: 中田収作
西原利治
https://ci.nii.ac.jp/author/DA15350731
山本泰猛
大西三朗
https://ci.nii.ac.jp/author/DA12340764
Publication Date: 1991
Publication Date (W3CDTF): 1991
Periodical title: 肝臓
No. or year of volume/issue: 32 6
Volume: 32
Issue: 6
Pages: 596-603
Publication date of volume/issue (W3CDTF): 1991
ISSN (Periodical Title): 04514203
ISSN-L (Periodical Title): 04514203
Publication (Periodical Title): The Japan Society of Hepatology
Text Language Code: ja
Subject Heading: HLA
原発性胆汁性肝硬変
抗胆管上皮細胞抗体
胆管上皮細胞
細胞傷害性T細胞
Target Audience: 一般
DOI: 10.2957/kanzo.32.596
https://doi.org/10.2957/kanzo.32.596
Related Material (URI): http://www.jstage.jst.go.jp/article/kanzo1960/32/6/32_6_596/_pdf
Data Provider (Database): 国立情報学研究所 : CiNii Research
https://cir.nii.ac.jp/
Original Data Provider (Database): Japan Link Center
https://japanlinkcenter.org/top
Crossref
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CiNii Articles
NAID: 130000878097

Digital

Summary, etc.: The mechanism of biliary epithelial cell injury was examined by assessing spleen-derived lymphocyte cytotoxicity to autologous biliary epithelial cells in patients with primary biliary cirrhosis(PBC). Spleen-lymphocytes had cytotoxicity against autologous biliary epithelial cells in all of 3 patients with PBC but in none of 6 patients with non-PBC. The cytotoxicity was found in T cells butnot in non-T cells. CD8 positive T lymphocytes were shown to be responsible for the cytotoxicity by negative depletion and the cytotoxicity was partially suppressed by anti-MHC class I. It was suggested that T cell cytotoxicity functioned through the interaction with MHC class I antigens. The cytotoxicity was dose-dependently suppressed by anti-biliary epithelial cell antibody. Our data support the current hypothesis that the pathogenesis of PBC is due to T cell autoimmunity against biliary epithelium.
原発性胆汁性肝硬変(PBC)患者の脾臓リンパ球の自己胆管上皮細胞に対する細胞傷害活性を測定する系を確立し,胆管上皮細胞の傷害機序を検討した.PBC 3症例の脾臓リンパ球は自己胆管上皮細胞に対して全例が細胞傷害活性を示したが,対照疾患6症例は全例細胞傷害活性を示さなかった.細胞傷害活性はT細胞分画に検出され,non-T細胞分面には検出されなかった.T細胞の細胞傷害活性はnegative depletionよりCD8陽性細胞集団に検出され,抗MHC class I抗体添加により部分的抑制を認め,細胞傷害活性の発現にMHC class I抗原の関与が示唆された.またT細胞傷害活性は抗胆管上皮抗体添加により濃度依存性に抑制された.以上の成績は,PBCの自己免疫機序による胆管上皮細胞傷害に,より直接的な根拠を与えるものと考えられる.
DOI: 10.2957/kanzo.32.596
Access Restrictions: インターネット公開
Data Provider (Database): 科学技術振興機構 : J-STAGE
http://www.jstage.jst.go.jp

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