Relationship between Serum TNF Activity and Insulin Resistance in Dairy Cows Affected with Naturally Occurring Fatty Liver
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- Material Type
- 記事
- Author/Editor
- 大塚 浩通小岩 政照初谷 敦 他
- Alternative Title
- 乳牛の脂肪肝における血清TNF活性とインスリン抵抗性の関連
- Periodical title
- The journal of veterinary medical science = 日本獣醫學会会誌
- No. or year of volume/issue
- 63(9) 2001.9
- Volume
- 63
- Issue
- 9
- Pages
- 1021～1025
- Publication date of volume/issue (W3CDTF)
- 2001-09
- ISSN (Periodical Title)
- 0916-7250
- ISSN-L (Periodical Title)
- 0916-7250
- Publication (Periodical Title)
- 東京 : 日本獣医学会
- Place of Publication (Country Code)
- JP
- Text Language Code
- eng
- NDLC
- Target Audience
- 一般
- Holding library
- 国立国会図書館
- Call No.
- Z18-350
- Data Provider (Database)
- 国立国会図書館 : 国立国会図書館雑誌記事索引
- Bibliographic ID (NDL)
- 5938492
- Bibliographic Record Category (NDL)
- 632
- Summary, etc.
- To clarify the relationship between tumor necrosis factor (TNF) and insulin resistance in dairy cows affected with fatty liver, naturally occurring cases were investigated. The affected cows were classified into following three groups according to histopathologic findings of the liver: mild fat droplet deposition (group 1; n=11), severe fat droplet deposition (group 2; n=10), and cloudy swelling (group 3; n=8). Serum TNF activities in Group 2 (8.67 ± 2.16 U/m<i>l</i>) and Group 3 (11.65 ± 1.92 U/m<i>l</i>) were significantly higher than that in Group 1 (3.57 ± 0.81 U/m<i>l</i>) (p<0.05). The insulin-tolerance tests showed that the insulin-stimulated glucose disposal rates (GDR) in Group 2 (27.6 ± 7.8%) and Group 3 (15.8 ± 9.1%) were significantly lower than that in Group 1 (41.7 ± 9.8%). There was a significant negative correlation between serum TNF activity and GDR in affected cows (r=-0.56, p<0.01). These results indicate that serum TNF activity is correlated with insulin resistance in cows with fatty liver.
- DOI
- 10.1292/jvms.63.1021
- Access Restrictions
- インターネット公開
- Data Provider (Database)
- 科学技術振興機構 : J-STAGE
- Summary, etc.
- To clarify the relationship between tumor necrosis factor (TNF) and insulin resistance in dairy cows affected with fatty liver, naturally occurring cases were investigated. The affected cows were classified into following three groups according to histopathologic findings of the liver: mild fat droplet deposition (group 1; n=11), severe fat droplet deposition (group 2; n=10), and cloudy swelling (group 3; n=8). Serum TNF activities in Group 2 (8.67 ± 2.16 U/m<i>l</i>) and Group 3 (11.65 ± 1.92 U/m<i>l</i>) were significantly higher than that in Group 1 (3.57 ± 0.81 U/m<i>l</i>) (p<0.05). The insulin-tolerance tests showed that the insulin-stimulated glucose disposal rates (GDR) in Group 2 (27.6 ± 7.8%) and Group 3 (15.8 ± 9.1%) were significantly lower than that in Group 1 (41.7 ± 9.8%). There was a significant negative correlation between serum TNF activity and GDR in affected cows (r=-0.56, p<0.01). These results indicate that serum TNF activity is correlated with insulin resistance in cows with fatty liver.
- DOI
- 10.1292/jvms.63.1021
- Access Restrictions
- インターネット公開
- Related Material (URI)
- Is Referenced By
- 周産期疾病発生牛群に対する免疫プロファイルテストの有用性Slow Recovery of Blood Glucose in the Insulin Tolerance Test during the Prepartum Transition Period Negatively Impacts the Nutritional Status and Reproductive Performance Postpartum of Dairy CowsRelationship between the degree of insulin resistance during late gestation and postpartum performance in dairy cows and factors that affect growth and metabolic status of their calves乳牛における潜在性ルーメンアシドーシス（SARA）に関する研究Influence of hepatic load from far-off dry period to early postpartum period on the first postpartum ovulation and accompanying subsequent fertility in dairy cows乳牛の周産期に発生した肝脂肪化と血清中遊離アミノ酸濃度Comparison of the Insulin Reaction of Peripheral Blood T Cells between Healthy Holstein Dairy Cows and JB during the Periparturient PeriodInternal medicine: Effect of hoof trimming before the dry period on productive performance in perinatal dairy cowsInternal medicine: Relationship between plasma vitamin C and serum diagnostic biochemical markers in lactating cows
- References
- Increased Milk Production Versus Reproductive and Energy Status of High Producing Dairy CowsTumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose outputProtection from obesity-induced insulin resistance in mice lacking TNF-α functionMetabolic Characteristics of Induced Ketosis in Normal and Obese Dairy CowsUltrastructural changes of the liver in spontaneously ketotic cowsTNF-α-Induced Insulin Resistance In Vivo and Its Prevention by TroglitazonePlasma Glucose Clearance and Insulin Response in Cows with Abomasal Displacement*Metabolic Changes in Blood and Liver During Development and Early Treatment of Experimental Fatty Liver and Ketosis in CowsIncreased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.A Body Condition Scoring Chart for Holstein Dairy CowsImpaired Glucose Tolerance and Heterogeneity of Insulin Responses in Cows with Abomasal DisplacementPrimary Ketosis in the High-Producing Dairy Cow: Clinical and Subclinical Disorders, Treatment, Prevention, and OutlookTumor necrosis factor-alpha suppresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates.
- Data Provider (Database)
- 国立情報学研究所 : CiNii Research
- Original Data Provider (Database)
- Japan Link Center雑誌記事索引データベースCrossrefPubMedCiNii ArticlesCrossrefCrossrefCrossrefCrossrefCrossrefCrossrefCrossrefCrossrefCrossref
- Bibliographic ID (NDL)
- 5938492
- NAID
- 110003920739