Electrospun collagen core/poly-l-lactic acid shell nanofibers for prolonged release of hydrophilic drug

Material type: 文書・図像類

Author: Huang, Wan-Yingほか

Publisher: Royal Society of Chemistry

Publication date: 2021-02-02

Material Format: Digital

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Note (General)：: The development of sustained control drug release for delivering hydrophilic drugs has been challenging due to a burst release. Nanofibers are used as...

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Material Type: 文書・図像類
Title: Electrospun collagen core/poly-l-lactic acid shell nanofibers for prolonged release of hydrophilic drug
Author/Editor: Huang, Wan-Ying
Hibino, Toshiya
Suye, Shin-ichiro
Fujita, Satoshi
Author Heading: Huang, Wan-Ying
Hibino, Toshiya
Suye, Shin-ichiro
Fujita, Satoshi
Publication, Distribution, etc.: Royal Society of Chemistry
Publication Date: 2021-02-02
Publication Date (W3CDTF): 2021-02-02
Periodical title: RSC Advances
No. or year of volume/issue: 2021 11
Volume: 2021
Issue: 11
Pages: 5703-5711
Text Language Code: eng
Target Audience: 一般
Note (General): The development of sustained control drug release for delivering hydrophilic drugs has been challenging due to a burst release. Nanofibers are used as materials that enable efficient drug delivery systems. In this study, we designed drug-encapsulated core–shell nanofibers comprising a hydrophilic core of collagen (Col) incorporated with berberine chloride (BC), an anti-inflammatory and anti-cancer agent used as a model drug, and a hydrophobic shell of poly-L-lactic acid (PLLA). Long-term drug release profiles under both the physiological and hydrolysis-accelerated conditions were measured and analyzed using a Korsmeyer–Peppas kinetics model. We found that the Col/PLLA core–shell fiber achieved a controllable long-term release of the hydrophilic drug incorporated inside the core by the slow degradation of the PLLA shell to prevent the burst release while PLLA monolithic fibers showed early release due to the dissolution of drug and the following rapid hydrolysis of fibers. As shown by the results of Col/PLLA core–shell fiber under a hydrolysis-accelerated condition to promote the release of drugs test, it would provide sustained release over 16 days under physiological conditions. Here, the development of the nanomaterial for the long-term drug release of hydrophilic drugs was achieved, leading to its potential medical application including cancer treatment.
source:https://pubs.rsc.org/en/content/articlelanding/2021/ra/d0ra08353d
Source: https://u-fukui.repo.nii.ac.jp/?action=repository_action_common_download&item_id=28891&item_no=1&attribute_id=22&file_no=1
https://u-fukui.repo.nii.ac.jp/?action=repository_action_common_download&item_id=28891&item_no=1&attribute_id=22&file_no=1
Access Restrictions: 限定公開
Rights (production): CC BY-NC
Related Material (DOI): 10.1039/D0RA08353D
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 福井大学 : 福井大学学術機関リポジトリ