Echocardiographic Epicardial Adipose Tissue Thickness Is Associated with Symptomatic Coronary Vasospasm during Provocative Testing

• Material Type: 博士論文
• Title: Echocardiographic Epicardial Adipose Tissue Thickness Is Associated with Symptomatic Coronary Vasospasm during Provocative Testing
• Author/Editor: Nishio, Susumu; Kusunose, Kenya; Yamada, Hirotsugu; Hirata, Yukina; Ise, Takayuki; Yamaguchi, Koji; Yagi, Shusuke; Soeki, Takeshi; Wakatsuki, Tetsuzo; Shimabukuro, Michio; Sata, Masataka
• Author Heading: Nishio, Susumu; Kusunose, Kenya; Yamada, Hirotsugu; Hirata, Yukina; Ise, Takayuki; Yamaguchi, Koji; Yagi, Shusuke; Soeki, Takeshi; Wakatsuki, Tetsuzo; Shimabukuro, Michio; Sata, Masataka
• Publication, Distribution, etc.: The American Society of Echocardiography|Elsevier
• Publication Date: 2017-08-23
• Publication Date (W3CDTF): 2017-08-23
• Alternative Title: 心エコー図検査で計測した心外膜下脂肪厚は誘発試験中の症候性冠攣縮と関連する
• Periodical title: Journal of the American Society of Echocardiography
• No. or year of volume/issue: 30 10
• Volume: 30
• Issue: 10
• Pages: 1021-1027.e1
• ISSN (Periodical Title): ISSN : 0894-7317
• Degree grantor/type: 徳島大学
• Date Granted: 2017-09-28
• Dissertation Number: 甲第3104号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Echocardiography; Epicardial adipose tissue; Vasospasm in patients with angina; Anterior interventricular groove
• Target Audience: 一般
• Note (General): Background: Epicardial adipose tissue (EAT) is the ectopic visceral fat surrounding the heart, which plays an important role in atherosclerosis of the coronary arteries via endothelial damage. Several studies have also suggested that vasospasmwith angina (VSA) causes endothelial dysfunction in the coronary arteries. The aimof this study was to evaluate the thickness of EAT in the anterior interventricular groove (EAT-AIG) using echocardiography in patients who had no obstructive coronary artery disease and were suspected of having VSA. Methods: Sixty-five patients who underwent intracoronary acetylcholine provocation testing for clinical indications were prospectively enrolled. VSA was diagnosed by coronary artery stenosis increase of >90% and the presentation of chest pain with ischemic changes on electrocardiography. Results: Subjects were divided into two groups, with and without significant coronary spasm (VSA group, 30 patients; non-VSA group, 35 patients), consistent with acetylcholine provocation testing. EAT-AIG thickness was significantly greater in the VSA group than in the non-VSA group (8.2±2.7 vs 6.1±2.5 mm, P = .002). By receiver operating characteristic analysis, EAT-AIG thickness had a high C statistic (area under the curve = 0.81, P < .001) after adjustment for conventional risk factors (smoking, diabetes mellitus, and dyslipidemia). EAT-AIG thickness had incremental diagnostic value over other conventional risk factors (area under the curve = 0.81 vs 0.64, P for comparison = .020). Conclusions: EAT-AIG thickness, which is noninvasively and easily measured using transthoracic echocardiography, can be one of multiple clinical variables associated with VSA.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1016/j.echo.2017.06.024
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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