The expression of 11β-hydroxysteroid dehydrogenase type 1 is increased in experimental periodontitis in rats

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The expression of 11β-hydroxysteroid dehydrogenase type 1 is increased in experimental periodontitis in rats

Material type: 博士論文

Author: 中田, 貴也

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Name of awarding university/degree: 大阪歯科大学,博士（歯学）

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Note (General)：: The involvement of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which converts inactive glucocorticoids into active glucocorticoids intracellul...

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Material Type: 博士論文
Title: The expression of 11β-hydroxysteroid dehydrogenase type 1 is increased in experimental periodontitis in rats
Author/Editor: 中田, 貴也
Author Heading: 中田, 貴也
Alternative Title: ラットの実験的歯周炎において11β-hydroxysteroid dehydrogenase type 1の発現が増加する
Degree grantor/type: 大阪歯科大学
Date Granted: 2017-03-10
Dissertation Number: 甲第788号
Degree Type: 博士（歯学）
Text Language Code: eng
Subject Heading: 11β-HSD1
Gulucocorticoids
Chronic periodontitis
Target Audience: 一般
Note (General): The involvement of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which converts inactive glucocorticoids into active glucocorticoids intracellularly, in metabolic diseases and chronic inflammatory diseases has been elucidated. To clarify the role of 11β-HSD1 in chronic periodontitis, the expression of 11β-HSD1 was investigated in an experimental periodontitis model in rats. Experimental periodontitis was induced by silk ligature. The expression of 11β-HSD1 was examined using real time PCR. The expression of 11β-HSD1 mRNA was significantly increased in experimental periodontitis compared with the control. This result suggests that the increased expression of 11β-HSD1, which results in increased levels of intracellular glucocorticoids, may play a role in the pathophysiology of experimental periodontitis.
2016年度
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https://osaka-dent.repo.nii.ac.jp/?action=repository_action_common_download&item_id=146&item_no=1&attribute_id=20&file_no=2
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https://osaka-dent.repo.nii.ac.jp/?action=repository_action_common_download&item_id=146&item_no=1&attribute_id=20&file_no=1
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Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
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Original Data Provider (Database): 大阪歯科大学 : 大阪歯科大学学術リポジトリ