Brain Pericytes are a Major Source of Lipocalin-type Prostaglandin D2 Synthase in the Cerebral Cortex after Ischemic Stroke

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Brain Pericytes are a Major Source of Lipocalin-type Prostaglandin D2 Synthase in the Cerebral Cortex after Ischemic Stroke

Material type: 博士論文

Author: 宮谷, 尚伽

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Name of awarding university/degree: 大阪歯科大学,博士（歯学）

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Note (General)：: Lipocalin-type prostaglandin D2 Synthase (LPGDS), a major cerebrospinal fluid (CSF) protein known as β-trace, reportedly scavenges biliverdin in the C...

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Material Type: 博士論文
Title: Brain Pericytes are a Major Source of Lipocalin-type Prostaglandin D2 Synthase in the Cerebral Cortex after Ischemic Stroke
Author/Editor: 宮谷, 尚伽
Author Heading: 宮谷, 尚伽
Alternative Title: 脳ペリサイトは脳梗塞後におけるリポカリン型プロスタグランジンD2合成酵素の起源である
Degree grantor/type: 大阪歯科大学
Date Granted: 2020-03-06
Dissertation Number: 甲第872号
Degree Type: 博士（歯学）
Text Language Code: eng
Subject Heading: LPGDS
iPC
Ishemic stroke
Brain pericytes
CNS
Target Audience: 一般
Note (General): Lipocalin-type prostaglandin D2 Synthase (LPGDS), a major cerebrospinal fluid (CSF) protein known as β-trace, reportedly scavenges biliverdin in the CSF of patients with subarachnoid hemorrhage and functions as a major amyloid β-chaperone, suggesting a clearance role in the central nervous system. However, the source of LPGDS in the cerebral cortex following stroke has not been elucidated. We examined changes in the cellular localization of LPGDS in post-stroke cerebral cortices of mice. Immunofluorescence staining were performed to determine the localization of LPGDS. Immunoelectron microscopy for LPGDS was also performed. In normal cerebral cortices, immunoreactive LPGDS structures were rarely observed. However, higher LPGDS expression levels were observed on PDGFRβ+ pericytes and nestin+ stem cells. Immunoelectron microscopy confirmed that pericytes in association with the endothelial cells expressed LPGDS. It is strongly expressed in brain pericytes following ischemic insult, suggesting that the ischemic pericytes are the major site of LPGDS expression following stroke. Knowledge of these expression profiles may be useful for future PC-based stem cell therapies.
2019年度
Source: fulltext
https://osaka-dent.repo.nii.ac.jp/?action=repository_action_common_download&item_id=255&item_no=1&attribute_id=20&file_no=2
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https://osaka-dent.repo.nii.ac.jp/?action=repository_action_common_download&item_id=255&item_no=1&attribute_id=20&file_no=1
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Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
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Original Data Provider (Database): 大阪歯科大学 : 大阪歯科大学学術リポジトリ