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細胞内デリバリー制御可能な多機能siRNAの創製と遺伝子サイレンシング

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細胞内デリバリー制御可能な多機能siRNAの創製と遺伝子サイレンシング

Material type
文書・図像類
Author
藤井, 政幸
Publisher
近畿大学
Publication date
2012-01-01
Material Format
Digital
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機関番号:34419; 研究種目:基盤研究(C); 研究期間:2010~2012; 課題番号:22550159; 研究分野:化学; 科研費の分科・細目:複合化学・生体関連化学Research Paperapplication/pdf

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https://kaken.nii.ac.jp/d/r/60199297.ja.html

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Summary, etc.:

研究成果の概要(和文): 固相フラグメント縮合法により化学合成したsiRNA-NESコンジュゲートによりK562細胞に発現するbcr/abl 遺伝子の発現の発現を200nMにおいて8.3%、50nMにおいて11.6 %に抑制した。また、siRNAと新規ペプチド(Pfect)とのコンプレックスを形成さ...

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Digital

Material Type
文書・図像類
Author/Editor
藤井, 政幸
Author Heading
Publication, Distribution, etc.
Publication Date
2012-01-01
Publication Date (W3CDTF)
2012-01-01
Alternative Title
Controlled intracellular delivery of Multi-functional siRNA and gene silencing
Periodical title
科学研究費助成事業研究成果報告書 (2012. )
Pages
1-6