Characterization of the role of aldehyde dehydrogensase-2 (ALDH2) and the effect of its human mutant allele (ALDH2*2) on airway stem cells function and predisposition to lung diseases

Material type: 文書・図像類

Author: Hegab, Ahmed

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Publication date: 2015

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Note (General)：: type:textALDH2はアルデヒド分解酵素の1つである。ALDH2の遺伝子多型は東アジアおける人口の40%程度にみられ, アルコールフラッシンク症候群の他, アルツハイマー病, 心疾患や食道癌などの悪性腫瘍を含む多くの疾患の危険因子となっていることがわかっている。しかし, ALDH2の遺伝子多...

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科研費研究者番号 : 00507915

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Material Type: 文書・図像類
Title: Characterization of the role of aldehyde dehydrogensase-2 (ALDH2) and the effect of its human mutant allele (ALDH2*2) on airway stem cells function and predisposition to lung diseases
Author/Editor: Hegab, Ahmed
Author Heading: Hegab, Ahmed
Publication Date: 2015
Publication Date (W3CDTF): 2015
Periodical title: 科学研究費補助金研究成果報告書
Text Language Code: jpn
eng
Subject Heading: ALDH2,aldehyde,lung,stem cell,mitochondria
Target Audience: 一般
Note (General): type:text
ALDH2はアルデヒド分解酵素の1つである。ALDH2の遺伝子多型は東アジアおける人口の40%程度にみられ, アルコールフラッシンク症候群の他, アルツハイマー病, 心疾患や食道癌などの悪性腫瘍を含む多くの疾患の危険因子となっていることがわかっている。しかし, ALDH2の遺伝子多型が気管・気管支・肺に及ほす影響に関しては, これまで研究がなされていない。我々は, ヒトとマウスの検体を利用して, ALDH2の遺伝子多型が呼吸器系に及ぼす影響を明らかにした。 Aldehyde dehydrogenases (ALDHs) play a major role in detoxification of aldehydes. High ALDH expression is observed in the stem cells of many organs. A common mutation in ALDH2 gene (ALDH2*2), which affects 40% of East Asians, results in inactivation of the enzyme. This mutation is associated with alcohol flushing syndrome and increased risk for cardiovascular and Alzheimer's diseases, and some cancers. However, the effect of this ALDH2 mutation on the lung has not been thoroughly examined. We detected several subtle effects of ALDH2 mutation on lungs. Some of these effects are similar to changes observed during normal aging, suggesting a "premature lung aging" effect.
研究種目 : 基盤研究(C)(一般) 研究期間 : 2013～2015 課題番号 : 25461196 研究分野 : 呼吸器内科
Access Restrictions: 限定公開
Related Material: 科研費研究者番号 : 00507915
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 慶應義塾大学 : 慶應義塾大学学術情報リポジトリ