面性不斉エノラートを経由した不斉合成を基盤とする生理活性天然物の全合成研究

Material type: 文書・図像類

Author: 吉村, 智之ほか

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Publication date: 2011-05-31

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Note (General)：: 金沢大学医薬保健研究域薬学系有用な生理活性天然物合成で鍵となる面性不斉エノラートを経由する分子内不斉共役付加反応及び分子内不斉アルキル化反応を詳細に検討した。その結果、分子内不斉共役付加反応ではマイケルアクセプターが、分子内不斉アルキル化では、エノラート及び求電子側鎖の隣接位にある芳香環上の置換基が...

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Material Type: 文書・図像類
Title: 面性不斉エノラートを経由した不斉合成を基盤とする生理活性天然物の全合成研究
Author/Editor: 吉村, 智之
Yoshimura, Tomoyuki
Author Heading: 吉村, 智之
Yoshimura, Tomoyuki
Publication Date: 2011-05-31
Publication Date (W3CDTF): 2011-05-31
Alternative Title: Asymmetric Total Synthesis of Bioactive Natural Products via Planar Chiral Enolate
Periodical title: 平成22(2010)年度科学研究費補助金若手研究(B) 研究成果報告書 = 2010 Fiscal Year Final Research Report
No. or year of volume/issue: 2009-2010
Volume: 2009-2010
Pages: 5p.-
Text Language Code: jpn
Subject Heading: 有機化学
全合成
面性不斉
Target Audience: 一般
Note (General): 金沢大学医薬保健研究域薬学系
有用な生理活性天然物合成で鍵となる面性不斉エノラートを経由する分子内不斉共役付加反応及び分子内不斉アルキル化反応を詳細に検討した。その結果、分子内不斉共役付加反応ではマイケルアクセプターが、分子内不斉アルキル化では、エノラート及び求電子側鎖の隣接位にある芳香環上の置換基がそれぞれ生成物の収率及び光学純度に重要な役割を果たすことが分かった。
Asymmetric intramolecular conjugate addition reaction and intramolecular alkylation reaction via planar chiral enolates were investigated in detail. As a result of various exanimation of reaction conditions, it was found that electron-withdrawing groups in the part of Michael acceptor played an important role in yield and optical purity of products in asymmetric conjugate addition reaction. On the other hand, the substituents on aromatic ring which are adjacent to enolate and electrophilic residue were found to affect yield and optical purity of products in asymmetric intramolecular alkylation reaction. These reactions would be used in the total syntheses of bioactive natural products as a key step.
出典：研究課題「面性不斉エノラートを経由した不斉合成を基盤とする生理活性天然物の全合成研究」課題番号21790014（KAKEN：科学研究費助成事業データベース（国立情報学研究所））（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21790014/21790014seika/)を加工して作成
DOI: 10.24517/00050878
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/search/?qm=20432320
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790014/
https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21790014/21790014seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA