Developing mouse models of inflammation-driven invasive gastric cancer to reveal novel therapeutic targets

Material type: 文書・図像類

Author: Nicholas, Barker

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Publication date: 2020-07-01

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Note (General)：: 金沢大学医薬保健研究域医学系新たな治療標的となるがん幹細胞集団を見出し、胃がん進行に対するそれらの寄与を見積もるためには、ヒト胃がんの発生を正確に模倣できる侵襲性・転移性胃がんマウスモデルの開発が喫緊の課題である。我々は、Lgr5陽性の胃がん細胞ががん幹細胞である可能性を検証し、胃がんの進展に対する...

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Material Type: 文書・図像類
Title: Developing mouse models of inflammation-driven invasive gastric cancer to reveal novel therapeutic targets
Author/Editor: Nicholas, Barker
Author Heading: Nicholas, Barker
Publication Date: 2020-07-01
Publication Date (W3CDTF): 2020-07-01
Alternative Title: Developing mouse models of inflammation-driven invasive gastric cancer to reveal novel therapeutic targets
Periodical title: 令和1(2019)年度科学研究費補助金基盤研究(A) 研究成果報告書 = 2019 Fiscal Year Final Research Report
No. or year of volume/issue: 2017-04-01 – 2020-03-31
Volume: 2017-04-01 – 2020-03-31
Pages: 9p.-
Text Language Code: eng
Subject Heading: Gastric cancer
Mouse model
Inflammation
Lgr5
Organoid
Tumor biology
Target Audience: 一般
Note (General): 金沢大学医薬保健研究域医学系
新たな治療標的となるがん幹細胞集団を見出し、胃がん進行に対するそれらの寄与を見積もるためには、ヒト胃がんの発生を正確に模倣できる侵襲性・転移性胃がんマウスモデルの開発が喫緊の課題である。我々は、Lgr5陽性の胃がん細胞ががん幹細胞である可能性を検証し、胃がんの進展に対するそれらの役割を明らかにするため、炎症依存的に侵襲性胃がんを発症する新規胃がんマウスモデルを作製した。これらのマウスモデルは、将来の抗がん治療の有効性/選択性を正確に評価するためのスクリーニング方法としても非常に重要であり、得られた知見は独創的で胃がん研究分野に大きな影響を与えると予想される。
There is an urgent, unmet need for accurate mouse models of invasive, metastatic gastric cancer that can be used to derive important mechanistic insight into gastric cancer progression and to identify candidate cancer stem cell populations as novel therapeutic targets. We generated the first inflammation-driven mouse models of invasive gastric cancer for use in studying gastric cancer development in the stomach, with a particular focus on understanding the role of Lgr5+ stem cells and Lgr5+ cancer stem cells in this process.These mouse models will also be invaluable as screening modalities for accurately evaluating the efficacy/selectivity of future anti-cancer therapeutics. The mouse models and experimental procedures detailed here are original and will deliver results that are expected to have a major impact on the gastric cancer research field.
研究課題/領域番号:17H01399, 研究期間(年度):2017-04-01 – 2020-03-31
出典：「Developing mouse models of inflammation-driven invasive gastric cancer to reveal novel therapeutic targets」研究成果報告書　課題番号17H01399（KAKEN：科学研究費助成事業データベース（国立情報学研究所））（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-17H01399/17H01399seika/)を加工して作成
DOI: 10.24517/00058574
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/ja/search/?kw=30787651
https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-17H01399/
https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-17H01399/17H01399seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA