Association Between Serum Vitamin D and All-Cause and Cause-Specific Death in a General Japanese Population - The Hisayama Study -

• Material Type: 博士論文
• Title: Association Between Serum Vitamin D and All-Cause and Cause-Specific Death in a General Japanese Population - The Hisayama Study -
• Author/Editor: 梅原, 薫
• Author Heading: 梅原, 薫
• Publication Date: 2018-03-20
• Publication Date (W3CDTF): 2018-03-20
• Alternative Title: 日本人地域一般住民における血清ビタミンＤレベルと総死亡および死因別死亡との関連 : 久山町研究
• Contributor: 中島, 康晴; 筒井, 裕之; 鴨打, 正浩
• Degree grantor/type: 九州大学
• Date Granted: 2018-03-20
• Date Granted (W3CDTF): 2018-03-20
• Dissertation Number: 甲第13938号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第13938号
• Text Language Code: eng
• Target Audience: 一般
• Note (General): BACKGROUND:Few studies have investigated the association between serum vitamin D levels and mortality in general Asian populations.Methods and Results:We examined the association of serum 1,25-dihydroxyvitamin D (1,25(OH)_2D) levels with the risk of all-cause and cause-specific death in an average 9.5-year follow-up study of 3,292 community-dwelling Japanese subjects aged ≥40 years (2002-2012). The multivariable-adjusted hazard ratio (HR) for all-cause death increased significantly with lower serum 1,25(OH)_2D levels (HR 1.54 [95% confidence interval, 1.18-2.01] for the lowest quartile, 1.31 [0.99-1.73] for the 2nd quartile, 0.94 [0.70-1.25] for the 3rd quartile, 1.00 [Ref.] for highest quartile; P for trend <0.001). A similar association was observed for cardiovascular and respiratory infection death (both P for trend <0.01), but not for cancer death or death from other causes. In the stratified analysis, the association between lower serum 1,25(OH)_2D levels and the risk of respiratory infection death was stronger in subjects with an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m than in those with eGFR ≥60 mL/min/1.73 m ; there was a significant heterogeneity in the association between eGFR levels (P for heterogeneity=0.04). / CONCLUSIONS:The findings suggested that a lower serum 1,25(OH)_2D level is a potential risk factor for all-cause death, especially cardiovascular and respiratory infection death, in the general Japanese population, and that lower serum 1,25(OH)_2D levels greatly increase the risk of respiratory infection death in subjects with kidney dysfunction.; PubMed番号 : 28428487
• DOI: 10.15017/1931791; https://doi.org/10.15017/1931791
• Persistent ID (NDL): info:ndljp/pid/11122676; https://dl.ndl.go.jp/pid/11122676
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2018-08-03T23:36:01+09:00
• Date Created (W3CDTF): 2018-05-30
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://dx.doi.org/10.15017/1931791; http://hdl.handle.net/2324/1931791
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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