SNX-2112 Induces Apoptosis and Autophagy of Nara-H Cells

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DOI[info:doi/10.21873/anticanres.12840]to the data of the same series

SNX-2112 Induces Apoptosis and Autophagy of Nara-H Cells

Persistent ID (NDL): info:ndljp/pid/11246018

Material type: 博士論文

Author: 福岡, 奈津子

Publisher: -

Publication date: 2018-12-26

Material Format: Digital

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Name of awarding university/degree: 香川大学,博士（医学）

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Note (General)：: Background/Aim: Selective heat shock protein 90 (Hsp90) inhibitor SNX-2112 exhibits antitumor activity in multiple cancer cell types. Here, the antitu...

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Material Type: 博士論文
Title: SNX-2112 Induces Apoptosis and Autophagy of Nara-H Cells
Author/Editor: 福岡, 奈津子
Author Heading: 福岡, 奈津子
Publication Date: 2018-12-26
Publication Date (W3CDTF): 2018-12-26
Degree grantor/type: 香川大学
Date Granted: 2018-12-26
Date Granted (W3CDTF): 2018-12-26
Dissertation Number: 甲第699号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第699号
Text Language Code: eng
Alias of Author: Fukuoka, Natsuko
Subject Heading: SNX-2112
apoptosis
autophagy
undifferentiated pleomorphic sarcoma
Target Audience: 一般
Note (General): Background/Aim: Selective heat shock protein 90 (Hsp90) inhibitor SNX-2112 exhibits antitumor activity in multiple cancer cell types. Here, the antitumor activity of SNX-2112 in Nara-H cells was analyzed.
Materials and Methods: Antitumor activity of SNX-2112 was assessed using a cell proliferation assay. We also examined the signalling pathways involved in SNX-2112-mediated autophagy and apoptosis of Nara-H cells by western blot and morphological analyses.
Results: Cell proliferation assays demonstrated that SNX-2112 inhibited Nara-H cell growth. Western blotting revealed that SNX-2112 induced apoptosis and autophagy, inhibited mammalian target of rapamycin (mTOR) phosphorylation, and suppressed the mitogen-activated protein kinase (MAPK) signalling pathway. Morphological analysis confirmed that SNX-2112 induced autophagy and apoptosis.
Conclusion: SNX-2112 induced autophagy and apoptosis of Nara-H cells by inhibiting mTOR and MAPK pathways. Our results support developing SNX-2112 to treat human soft tissue sarcomas.
DOI: info:doi/10.21873/anticanres.12840
https://doi.org/info:doi/10.21873/anticanres.12840
Persistent ID (NDL): info:ndljp/pid/11246018
https://dl.ndl.go.jp/pid/11246018
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2019-03-03T03:58:25+09:00
Date Created (W3CDTF): 2020-10-27
Format (IMT): PDF
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): https://kagawa-u.repo.nii.ac.jp/records/342
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp