Correlation of bone marrow 2-deoxy-2-[¹⁸F]fluoro-D-glucose uptake with systemic inflammation in patients with newly diagnosed endometrial cancer

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Correlation of bone marrow 2-deoxy-2-[¹⁸F]fluoro-D-glucose uptake with systemic inflammation in patients with newly diagnosed endometrial cancer

Persistent ID (NDL): info:ndljp/pid/12863782

Material type: 博士論文

Author: 石橋, めぐみ

Publisher: -

Publication date: 2023-02-15

Material Format: Digital

Capacity, size, etc.: -

Name of awarding university/degree: 香川大学,博士（医学）

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Note (General)：: Objective: To clarify the relationship between 2-deoxy-2-[¹⁸F]fluoro-D-glucose (FDG) uptake of bone marrow and systemic inflammation in patients with ...

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Material Type: 博士論文
Title: Correlation of bone marrow 2-deoxy-2-[¹⁸F]fluoro-D-glucose uptake with systemic inflammation in patients with newly diagnosed endometrial cancer
Author/Editor: 石橋, めぐみ
Author Heading: 石橋, めぐみ
Publication Date: 2023-02-15
Publication Date (W3CDTF): 2023-02-15
Alternative Title: 子宮内膜がん患者における骨髄2-deoxy-2-[¹⁸F] fluoro-D-glucose集積と全身性炎症反応との関連性
Degree grantor/type: 香川大学
Date Granted: 2023-02-15
Date Granted (W3CDTF): 2023-02-15
Dissertation Number: 乙第300号
Degree Type: 博士（医学）
Text Language Code: eng
Alias of Author: Ishibashi, Megumi
Subject Heading: bone marrow
endometrial cancer
fluoro-D-glucose
PET
Target Audience: 一般
Note (General): Objective: To clarify the relationship between 2-deoxy-2-[¹⁸F]fluoro-D-glucose (FDG) uptake of bone marrow and systemic inflammation in patients with newly diagnosed endometrial cancer.
Methods: A total of 119 patients with untreated endometrial cancer underwent FDG PET/computed tomography (CT). For bone marrow FDG uptake, the mean standardized uptake value (SUVmean) of the five vertebrae (T11-12 and L3-L5) was measured and averaged (bone marrow SUV). The bone marrow-to-liver ratio (BLR) was calculated by dividing the bone marrow SUV by the SUVmean of the normal liver. FDG PET parameters were correlated with white blood cell count, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and C-reactive protein (CRP), albumin, and hemoglobin levels. They were also correlated with FIGO stage.
Results: Bone marrow SUV and BLR showed significant positive correlations with white blood cell count, NLR, and CRP level and significant negative correlations with albumin level. BLR also showed a significant positive correlation with PLR. No significant differences in bone marrow SUV and BLR were apparent according to FIGO stage.
Conclusion: Pretreatment FDG PET/CT in patients with newly diagnosed endometrial cancer may provide information on host systemic inflammation as assessed by bone marrow FDG uptake.
Persistent ID (NDL): info:ndljp/pid/12863782
https://dl.ndl.go.jp/pid/12863782
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2023-05-05T22:12:34+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): https://kagawa-u.repo.nii.ac.jp/records/11715
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp