Impact of gender in renal cell carcinoma: the relationship of FABP7 and BRN2 expression with overall survival

• Material Type: 博士論文
• Title: Impact of gender in renal cell carcinoma: the relationship of FABP7 and BRN2 expression with overall survival
• Author/Editor: Tan, Cheng
• Author Heading: Tan, Cheng
• Publication, Distribution, etc.: SAGE Publications
• Publication Date: 2014
• Publication Date (W3CDTF): 2014
• Alternative Title: 腎癌における性別の影響: 全生存期間に及ぼすFABP7 とBRN2 発現の関係
• Periodical title: Clinical Medicine Insights: Oncology
• Degree grantor/type: 浜松医科大学
• Date Granted: 2014-03-17
• Date Granted (W3CDTF): 2014-03-17
• Dissertation Number: 甲第682号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第682号
• Text Language Code: eng
• Subject Heading: BRN2; FABP7; gender; overall survival; renal cell carcinoma
• Target Audience: 一般
• Note (General): doctoral; 医学系研究科; Objective: To investigate the relationship between gender differences in fatty acid-binding protein7 (FABP7) and BRN2 (POU class 3 homeobox 2) expression in renal cell carcinoma (RCC) and the prognosis of patients with RCC.Materials and Methods: immunohistochemical (IHC) staining as well as reverse transcription-polymerase chain reaction (RT-PCR) was performed in renal tissues from 103 patients (83 men, mean age=63.6 years old; 20 women, mean age=63.1 years old) underwent radical nephrectomy from January 1, 2001 through December 31, 2010. The probability of overall patient survival was estimated using the Kaplan-Meier method.Results: FABP7 mRNA expression was more frequent in men (P=0.07) while BRN2 protein expression was significantly more frequent in women (P=0.029). In particular, FABP7 was expressed in 100% of G1 renal cell carcinoma both in mRNA and protein levels. In women, FABP7 (-) and BRN2 (+) groups had a worse prognosis both in mRNA level (P=0.038) and protein level (P=0.058). BRN2 was expressed 100% of papillary RCC both in mRNA and protein levels.Conclusions: Our results demonstrated that gender was a key factor in FABP7 and BRN2 expression in RCC, and the combination with FABP7 and BRN2 stratified by gender could be a new potential prognostic factor in patients with RCC.
• DOI: info:doi/10.4137/CMO.S13684; https://doi.org/info:doi/10.4137/CMO.S13684
• Persistent ID (NDL): info:ndljp/pid/8953196; https://dl.ndl.go.jp/pid/8953196
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Available (W3CDTF): 2015-03-03
• Date Accepted (W3CDTF): 2015-02-03T05:25:05+09:00
• Date Created (W3CDTF): 2018-08-27
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10271/2786; https://hama-med.repo.nii.ac.jp/records/2654
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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