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変形性関節疾患に続発する膝関節の滑膜脂肪増殖 / 鈴木, 智大

Thu, 26 Sep 2024 18:36:37 +0900

鈴木, 智大. 変形性関節疾患に続発する膝関節の滑膜脂肪増殖. 東北ジャーナル刊行会, 2019-05

ラクトバチルスによる処置はマウスに接種した頭頸部扁平上皮癌細胞の増殖を阻害する / 宮口, 潤

Thu, 10 Oct 2024 20:59:21 +0900

宮口, 潤. ラクトバチルスによる処置はマウスに接種した頭頸部扁平上皮癌細胞の増殖を阻害する. 東北ジャーナル刊行会, 2018-08

The A>T Polymorphism of the Tribbles Homolog 1 Gene Is Associated with Serum Triglyceride Concentrations in Japanese Community-Dwelling Women / 池岡, 俊幸

Thu, 24 Aug 2023 18:51:19 +0900

池岡, 俊幸. The A>T Polymorphism of the Tribbles Homolog 1 Gene Is Associated with Serum Triglyceride Concentrations in Japanese Community-Dwelling Women. 東北ジャーナル刊行会, 2015-03-20

Smoking Aggravates the Impaired Pulmonary Function of Officially Acknowledged Female Victims of Air Pollution of 40 Years Ago / 西中川, 剛

Thu, 24 Aug 2023 18:51:16 +0900

西中川, 剛. Smoking Aggravates the Impaired Pulmonary Function of Officially Acknowledged Female Victims of Air Pollution of 40 Years Ago. 東北ジャーナル刊行会, 2015-02-04

Pulmonary Rehabilitation Improves Exercise Capacity and Dyspnea in Air Pollution-Related Respiratory Disease / 宮本, 直美

Thu, 24 Aug 2023 18:50:35 +0900

宮本, 直美. Pulmonary Rehabilitation Improves Exercise Capacity and Dyspnea in Air Pollution-Related Respiratory Disease. 東北ジャーナル刊行会, 2014-03-20

Air Pollution Irreversibly Impairs Lung Function: A Twenty-Year Follow-Up of Officially Acknowledged Victims in Japan / 柳田, 賴英

Thu, 24 Aug 2023 18:50:34 +0900

柳田, 賴英. Air Pollution Irreversibly Impairs Lung Function: A Twenty-Year Follow-Up of Officially Acknowledged Victims in Japan. 東北ジャーナル刊行会, 2014-03-20

変形性関節疾患に続発する膝関節の滑膜脂肪増殖 248 1 / 鈴木, 智大

Fri, 31 Oct 2025 00:27:34 +0900

鈴木, 智大. 変形性関節疾患に続発する膝関節の滑膜脂肪増殖 248 1. 東北ジャーナル刊行会, 2019-05; 248 1

ラクトバチルスによる処置はマウスに接種した頭頸部扁平上皮癌細胞の増殖を阻害する 245 4 / 宮口, 潤

Fri, 31 Oct 2025 00:26:06 +0900

宮口, 潤. ラクトバチルスによる処置はマウスに接種した頭頸部扁平上皮癌細胞の増殖を阻害する 245 4. 東北ジャーナル刊行会, 2018-08; 245 4

The A>T Polymorphism of the Tribbles Homolog 1 Gene Is Associated with Serum Triglyceride Concentrations in Japanese Community-Dwelling Women 233 2 / 池岡, 俊幸

Thu, 30 Oct 2025 00:47:06 +0900

池岡, 俊幸. The A>T Polymorphism of the Tribbles Homolog 1 Gene Is Associated with Serum Triglyceride Concentrations in Japanese Community-Dwelling Women 233 2. 東北ジャーナル刊行会, 2015-03-20; 233 2
Recent genome-wide association studies have identified Tribbles homolog 1 (TRIB1) as one of the candidate genes associated with lipid profiles. TRIB1 is known to interact with MAP kinases, thereby regulating their activities. The single nucleotide polymorphism rs2954029 of TRIB1 is located within an intron and is associated with lipid profiles. The aim of the present study is to investigate the TRIB1 rs2954029 (A>T polymorphism) with conventional predictors of coronary artery diseases such as carotid intima-media thickness (CIMT) and cardio-ankle vascular index (CAVI), and with lipid profiles in general population. This study enrolled 2,581 Japanese adults, 942 men and 1,639 women with a median age of 68 years (range 29 to 94 years), who participated in a screening program for the general population living in Goto City, Nagasaki Prefecture, Japan from 2008 to 2010. For the determination of TRIB1 rs2954029 genotypes, the polymerase chain reaction method was used. The differences in each parameter among the TRIB1 rs2954029 genotypes were evaluated using analysis of covariance. Genotype frequencies of TRIB1 rs2954029 in all participants were 25.5% for AA, 50.4% for AT, and 24.0% for TT. In women, the AA genotype showed significantly higher log triglyceride (TG) concentrations than the AT genotype (P = 0.004) and the AT + TT genotypes (P = 0.004). On the other hand, there were no associations with CIMT and CAVI among the TRIB1 rs2954029 genotypes. In conclusion, the TRIB1 rs2954029 is associated with serum TG concentrations in Japanese community-dwelling women.

Smoking Aggravates the Impaired Pulmonary Function of Officially Acknowledged Female Victims of Air Pollution of 40 Years Ago 234 2 / 西中川, 剛

Thu, 30 Oct 2025 20:39:45 +0900

西中川, 剛. Smoking Aggravates the Impaired Pulmonary Function of Officially Acknowledged Female Victims of Air Pollution of 40 Years Ago 234 2. 東北ジャーナル刊行会, 2015-02-04; 234 2
Air pollution due to industrial waste and tobacco smoke is detrimental to pulmonary function. However, the combined effects of air pollution and smoking on pulmonary function have not been investigated. We examined the combined effect of air pollution of 40 years ago and concurrent smoking on the pulmonary function of officially acknowledged female victims in Japan, because females are more susceptible to the adverse effects of both irritants than males. The subjects comprised 655 female victims living in one of two areas with air pollution of 40 years ago and 572 females living in an area without air pollution. All victims have been prescribed standard respiratory medications. Pulmonary function was measured in 2000 for air-pollution groups (130 smokers and 525 non-smokers; mean age, 68.4 years) and during the period of 2004 to 2013 for non-air-pollution groups (113 smokers and 459 non-smokers; mean age, 69.0 years). The smokers included both current smokers and ex-smokers. The victims with a history of smoking had significantly lower forced expiratory volume in 1 second (FEV1% predicted) (mean, 74%) and significantly lower FEV1/forced vital capacity (FVC) (mean, 70%) than the other groups (P < 0.001). Thus, smoking aggravates the pulmonary function in officially acknowledged female victims, despite the improved air pollution and the continuous medical care provided by the government. In conclusion, exposure to air pollution of 40 years ago and cigarette smoking are associated with reduced pulmonary function. These results highlight the importance of measures aimed at smoking cessation and limiting air pollution.

Air Pollution Irreversibly Impairs Lung Function: A Twenty-Year Follow-Up of Officially Acknowledged Victims in Japan 230 3 / 柳田, 賴英

Thu, 30 Oct 2025 20:42:00 +0900

柳田, 賴英. Air Pollution Irreversibly Impairs Lung Function: A Twenty-Year Follow-Up of Officially Acknowledged Victims in Japan 230 3. 東北ジャーナル刊行会, 2014-03-20; 230 3
Lung function is one of the strongest determinants of cardiopulmonary health and longevity. Long-term exposure to air pollution has been associated with decreased lung function. We undertook a retrospective study to compare the long-term consequences of air pollution in two areas of Japan: Mizushima, Okayama Prefecture and Kitakyushu, Fukuoka Prefecture. Industrialization began in Mizushima in the 1940s, whereas it began in Kitakyushu in the early 1900s. In Kitakyushu, levels of nitrogen dioxide have been higher compared to the Mizushima area. The subjects comprised 623 officially acknowledged victims of pollution-related illness (489 from Mizushima and 134 from Kitakyushu). All subjects were lifetime non-smokers and aged 65 years or older at the time of their last medical examination in 2009. Demographic data including diagnosed lung diseases and lung function at the time of certification assessment performed between 1973 and 1988 were obtained. The subjects from Kitakyushu were significantly younger (47.1 vs. 51.0 years, p < 0.001) and a higher percentage had asthma (91.2 vs. 36.8%, p < 0.001) compared to those from Mizushima. Furthermore, all measures of lung function were significantly lower in Kitakyushu group at the time of the certification assessment (p < 0.001) and at the follow-up (p < 0.001). However, no significant differences were observed in the annual mean decline in lung function between the two groups, despite the overall decrease in air pollution. In conclusion, the normal lung function is not restored even after improvement of air pollution. It is essential for every city to prevent air pollution.

Pulmonary Rehabilitation Improves Exercise Capacity and Dyspnea in Air Pollution-Related Respiratory Disease 232 1 / 宮本, 直美

Thu, 30 Oct 2025 00:11:45 +0900

宮本, 直美. Pulmonary Rehabilitation Improves Exercise Capacity and Dyspnea in Air Pollution-Related Respiratory Disease 232 1. 東北ジャーナル刊行会, 2014-03-20; 232 1
Air pollution in Japan caused respiratory disease, such as chronic bronchitis and asthma, in many individuals in the 1960s. Although air pollution has decreased, many victims of air pollution-related respiratory disease are limited in their activities of daily living because of respiratory symptoms. The purpose of this study was to evaluate the efficacy of pulmonary rehabilitation in victims of air pollution-related chronic bronchitis or asthma. Subjects were enrolled in a 12-week (2-week inpatient followed by 10-week outpatient) pulmonary rehabilitation program. The program comprised conditioning, strength training, endurance training, and patient education. We assessed the Modifed Medical Research Council (MMRC) dyspnea grade, pulmonary function, peripheral muscle force, incremental shuttle walk distance (ISWD), and physical activity at baseline and immediately after the program. Twenty-nine subjects (mean age 74.2 ± 10.1 years, 11 males) completed the program, including 11 subjects with COPD and 18 subjects with asthma. Following rehabilitation, the participants (n = 29) showed signifcant improvements in MMRC dyspnea grade, vital capacity % predicted, quadriceps force and ISWD (all P < 0.05). Sub-group analyses revealed that all these variables were signifcantly improved in subjects with asthma. In contrast, subjects with COPD showed signifcant improvements only in quadriceps force and ISWD (both P < 0.05). Thus, pulmonary rehabilitation is an effective method of improving exercise capacity and dyspnea in officially acknowledged victims of air pollution-related asthma. In conclusion, we recommend that patients with chronic bronchitis or asthma, resulting from exposure to air pollution, are referred for pulmonary rehabilitation.

Tohoku Journal of Experimental Medicine

Tue, 09 Dec 2025 16:04:17 +0900

Tohoku Journal of Experimental Medicine. 東北ジャーナル刊行会