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門脈-肝臓領域Na[+]受容器感度および受容器発現に対する高食塩食の影響 / 森田, 啓之, 岐阜大学

Thu, 15 Dec 2005 08:59:59 +0900

森田, 啓之, 岐阜大学. 門脈-肝臓領域Na[+]受容器感度および受容器発現に対する高食塩食の影響. 2001-2002

体液量・電解質調節における腎Na/K/2Cl輸送体(NKCC2)の役割 / 河原, 克雅, 北里大学

Thu, 27 Jan 2022 18:42:12 +0900

河原, 克雅, 北里大学. 体液量・電解質調節における腎Na/K/2Cl輸送体(NKCC2)の役割. 1999-2000

A subpopulation of agouti-related peptide neurons exciting corticotropin-releasing hormone axon terminals in median eminence led to hypothalamic-pituitary-adrenal axis activation in response to food restriction / Yesmin, Mst Ruksana

Mon, 01 Jan 2024 19:04:37 +0900

A subpopulation of agouti-related peptide neurons exciting corticotropin-releasing hormone axon terminals in median eminence led to hypothalamic-pituitary-adrenal axis activation in response to food restriction 15 / Yesmin, Mst Ruksana

Wed, 29 Oct 2025 02:51:04 +0900

Yesmin, Mst Ruksana. A subpopulation of agouti-related peptide neurons exciting corticotropin-releasing hormone axon terminals in median eminence led to hypothalamic-pituitary-adrenal axis activation in response to food restriction 15. Frontiers Media S.A., 2022-09-29; 15
The excitatory action of gamma-aminobutyric-acid (GABA) in the median-eminence (ME) led to the steady-state release of corticotropin-releasing hormone (CRH) from CRH axon terminals, which modulates the hypothalamic-pituitary-adrenal (HPA) axis. However, in ME, the source of excitatory GABAergic input is unknown. We examined agouti-related peptide (AgRP) expressing neurons in the arcuate nucleus as a possible source for excitatory GABAergic input. Here, we show that a subpopulation of activated AgRP neurons directly project to the CRH axon terminals in ME elevates serum corticosterone levels in 60% food-restricted mice. This increase in serum corticosterone is not dependent on activation of CRH neuronal soma in the paraventricular nucleus. Furthermore, conditional deletion of NaC-KC-2Cl⁻ cotransporter-1 (NKCC1), which promotes depolarizing GABA action, from the CRH axon terminals results in significantly lower corticosterone levels in response to food restriction. These findings highlight the important role of a subset of AgRP neurons in HPA axis modulation via NKCC1-dependent GABAergic excitation in ME.