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軸索路形成を調節する糖鎖chondroitin sulfateを受容する分子機構 / 一條裕之, 筑波大学 [著]

Wed, 15 Dec 2004 19:18:26 +0900

一條裕之, 筑波大学 [著]. 軸索路形成を調節する糖鎖chondroitin sulfateを受容する分子機構. [一條裕之], 2002-2003; 2004.3

ネコ網膜神経節細胞の軸索変性・再生に関する電気生理学的・分子生物学的研究 / 福田淳, 大阪大学 [著]

Mon, 31 Jan 2022 23:12:52 +0900

福田淳, 大阪大学 [著]. ネコ網膜神経節細胞の軸索変性・再生に関する電気生理学的・分子生物学的研究. [福田淳], 1996-1998

Optimized Culture System to Induce Neurite Outgrowth From Retinal Ganglion Cells in Three-Dimensional Retinal Aggregates Differentiated From Mouse and Human Embryonic Stem Cells / 前川, 有紀

Thu, 24 Aug 2023 18:45:27 +0900

The retina and circadian rhythms / Gianluca Tosini ... [et al.], editors

Fri, 06 Mar 2026 10:03:02 +0900

Gianluca Tosini ... [et al.], editors. The retina and circadian rhythms. Springer, c2014. ISBN:9781461496120

Parallel processing in the visual system : the classification of retinal ganglion cells and its impact on the neurobiology of vision / Jonathan Stone.

Sat, 26 Dec 1987 09:00:00 +0900

Parallel processing in the visual system : the classification of retinal ganglion cells and its impact on the neurobiology of vision / Jonathan Stone.. Plenum Press, c1983., Perspectives in vision research. ISBN:0306412209

神経保護評価に向けた網膜神経節細胞の細胞体と軸索の生体内定量的観察法の確立 / 東出, 朋巳ほか

Tue, 11 Jul 2023 20:22:19 +0900

東出, 朋巳; Higashide, Tomomi. 神経保護評価に向けた網膜神経節細胞の細胞体と軸索の生体内定量的観察法の確立. 金沢大学附属病院眼科, 2007-03. DOI:10.24517/00050729

Parallel processing in the visual system : the classification of retinal ganglion cells and its impact on the neurobiology of vision / Jonathan Stone

Fri, 06 Mar 2026 10:03:02 +0900

Jonathan Stone. Parallel processing in the visual system : the classification of retinal ganglion cells and its impact on the neurobiology of vision. Plenum Press, c1983. ISBN:0306412209

The neurons of the first optic ganglion of the bee (Apis mellifera) : Berlin, Heidelberg, New York / Willi A. Ribi

Fri, 09 Jan 2026 11:13:45 +0900

Willi A. Ribi. The neurons of the first optic ganglion of the bee (Apis mellifera) : Berlin, Heidelberg, New York; : New York, Heidelberg, Berlin. Springer-Verlag, 1975. ISBN:3540070966; 0387070966

網膜神経節細胞傷害に対するバロシン含有タンパク質モジュレーターによる神経保護におけるエンドセリン系の関与 / 日下, 真実

Sat, 07 Mar 2026 14:40:14 +0900

日下, 真実. 網膜神経節細胞傷害に対するバロシン含有タンパク質モジュレーターによる神経保護におけるエンドセリン系の関与. Kyoto University, 2024-03-25. DOI:10.14989/doctor.k25160; 10.14989/doctor.k25160

Gene expression changes in the retina after systemic administration of aldosterone / 小野, 葵

Thu, 30 Oct 2025 00:56:14 +0900

小野, 葵. Gene expression changes in the retina after systemic administration of aldosterone. 2018-09-27
PurposeRetinal ganglion cell (RGC) loss associated with thinning of the retinal nerve fiber layer without elevated intraocular pressure (IOP) occurs after the systemic administration of aldosterone. Since it is important to determine the mechanism of cell death independent of the IOP, we examined gene expression changes in the retina after the systemic administration of aldosterone.; MethodsFollowing subcutaneous implantation of an osmotic minipump into the mid-scapular region of rats, we administered an 80 μg/kg/day dose of aldosterone. Differences in the gene expression in the retina between normal rats and aldosterone-treated rats were investigated using microarrays. Real-time PCR was used to confirm the differential expression.; ResultsAnalysis of the microarray data sets revealed the upregulation of 24 genes and the downregulation of 24 genes of key apoptosis-specific genes. Real-time PCR revealed 4 genes (Cdkn1a, Tbox5, Pf4, Vdr) were upregulated while 12 genes (Acvr1c, Asns, Bard1, Card9, Crh, Fcgr1a, Inhba, Kcnh8, Lck, Phlda1, Ptprc, Sh3rf1) were downregulated.; ConclusionsSignificant increases and decreases were noted in several genes after the systemic administration of aldosterone. Further studies will need to be undertaken in order to definitively clarify the role of these genes in the eyes of animals with normal-tension glaucoma.

レーザーによる軸索障害後の網膜神経節細胞のミトコンドリアの軸索内輸送速度の変化 / 横田, 聡

Sat, 07 Mar 2026 14:36:44 +0900

横田, 聡. レーザーによる軸索障害後の網膜神経節細胞のミトコンドリアの軸索内輸送速度の変化. 京都大学 (Kyoto University), 2017-03-23. DOI:10.14989/doctor.k20244; 10.14989/doctor.k20244

Optimized Culture System to Induce Neurite Outgrowth From Retinal Ganglion Cells in Three-Dimensional Retinal Aggregates Differentiated From Mouse and Human Embryonic Stem Cells 41 4 / 前川, 有紀

Thu, 30 Oct 2025 00:12:10 +0900

前川, 有紀. Optimized Culture System to Induce Neurite Outgrowth From Retinal Ganglion Cells in Three-Dimensional Retinal Aggregates Differentiated From Mouse and Human Embryonic Stem Cells 41 4. Taylor & Francis, 2016-09-30; 41 4
Purpose: To establish a practical research tool for studying the pathogenesis of retinal ganglion cell (RGC) diseases, we optimized culture procedures to induce neurite outgrowth from three-dimensional self-organizing optic vesicles (3D-retinas) differentiated in vitro from mouse and human embryonic stem cells (ESCs). Materials and methods: The developing 3D-retinas isolated at various time points were placed on Matrigel-coated plates and cultured in media on the basis of the 3D-retinal culture or the retinal organotypic culture protocol. The number, length, and morphology of the neurites in each culturecondition were compared. Results: First, we confirmed that Venus-positive cells were double-labeled with a RGC marker, Brn3a, in the 3D-retina differentiated from Fstl4::Venus mouse ESCs, indicating specific RGC-subtype differentiation. Second, Venus-positive neurites grown from these RGC subsets werepositive for beta-III tubulin and SMI312 by immunohistochemistry. Enhanced neurite outgrowth was observed in the B27-supplemented Neurobasal-A medium on Matrigel-coated plates from the optic vesicles isolated after 14 days of differentiation from mouse ESCs. For the differentiated RGCs from human ESCs, we obtained neurite extension of >4?mm by modifying Matrigel coating and the culture medium from the mouse RGC culture. Conclusion: We successfully optimized the culture conditions to enhance lengthy and high-frequency neurite outgrowth in mouse and humanmodels. The procedure would be useful for not only developmental studies of RGCs, including maintenance and projection, but also clinical,pathological, and pharmacological studies of human RGC diseases.

Gene expression changes in the retina after systemic administration of aldosterone / 小野, 葵

Sat, 24 Aug 2024 18:05:50 +0900

小野, 葵. Gene expression changes in the retina after systemic administration of aldosterone