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            <title>Oral administration of L-carnitine improves the clinical outcome of fertility in patients with IVF treatment / &#x5317;&#x91ce;, &#x88d5;&#x5b50;</title>
            <link>https://ndlsearch.ndl.go.jp/books/R000000025-I011890004293777</link>
            <description>&#x5317;&#x91ce;, &#x88d5;&#x5b50;. Oral administration of L-carnitine improves the clinical outcome of fertility in patients with IVF treatment. &#x4e09;&#x91cd;&#x5927;&#x5b66;, 2019-03-25</description>
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            <pubDate>Fri, 03 Nov 2023 18:17:23 +0900</pubDate>
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            <title>Oral administration of L-carnitine improves the clinical outcome of fertility in patients with IVF treatment / &#x5317;&#x91ce;, &#x88d5;&#x5b50;</title>
            <link>https://ndlsearch.ndl.go.jp/books/R100000039-I11378277</link>
            <description>&#x5317;&#x91ce;, &#x88d5;&#x5b50;. Oral administration of L-carnitine improves the clinical outcome of fertility in patients with IVF treatment. &#x4e09;&#x91cd;&#x5927;&#x5b66;, 2019-03-25&lt;br&gt;Age-dependent decline of mitochondrial function has been proposed to be a main cause of decline of embryo quality. Then, L-carnitine plays important roles in reducing the membranous toxicity of free-fatty acids by forming acyl-carnitine and promoting b-oxidation, preventing cell damage. Recent research revealed that L-carnitine played important roles in vitro in oocyte growth, oocyte maturation and embryo development. However, such beneficial effects of L-carnitine in vivo have yet to be verified. The effect of oral L-carnitine supplementation on embryo quality and implantation potential was examined. A total of 214 patients were included in this study. They all previously received in vitro fertilization-embryo transfer (IVF-ET) and failed to conceive. Then they were administered L-carnitine for 82 days on average and underwent IVF-ET again. There were no significant differences in the total number of retrieved oocytes, and their maturation and fertilization rates between before and after L -carnitine administration. The quality of embryos on Days 3 and 5 after insemination was improved following L-carnitine administration (p&lt;.05) in cycles after L-carnitine administration compared with previous cycles. Healthy neonates were born after IVF-ET following L-carnitine administration. Our data suggested that oral administration of L-carnitine to fertility patients improved the developmental competence of their oocytes after insemination.</description>
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            <link>https://ndlsearch.ndl.go.jp/books/R100000039-I14491826</link>
            <description>&#x9752;&#x67f3;, &#x512a;&#x5b50;. &#x4e0d;&#x598a;&#x6cbb;&#x7642;&#x5f8c;&#x306e;&#x598a;&#x7523;&#x5a66;&#x306b;&#x5bfe;&#x3059;&#x308b;&#x52a9;&#x7523;&#x5e2b;&#x306e;&#x502b;&#x7406;&#x7684;&#x5b9f;&#x8df5;&#x3068;&#x95a2;&#x9023;&#x8981;&#x56e0;. 2017-09-19. DOI:10.34414/0000000239; 10.34414/0000000239</description>
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            <pubDate>Fri, 21 Nov 2025 22:21:37 +0900</pubDate>
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