https://ndlsearch.ndl.go.jp/search?cs=bib&from=0&size=20&q-subject=%22free-fatty%20acids%22 トップページ等で使われる標準の書誌検索定義 Sat, 18 Jul 2026 00:00:00 +0900 https://ndlsearch.ndl.go.jp/books/R000000025-I011890004293777 北野, 裕子. Oral administration of L-carnitine improves the clinical outcome of fertility in patients with IVF treatment. 三重大学, 2019-03-25 https://ndlsearch.ndl.go.jp/books/R000000025-I011890004293777 博士論文 Fri, 03 Nov 2023 18:17:23 +0900 https://ndlsearch.ndl.go.jp/books/R100000039-I11378277 北野, 裕子. Oral administration of L-carnitine improves the clinical outcome of fertility in patients with IVF treatment. 三重大学, 2019-03-25<br>Age-dependent decline of mitochondrial function has been proposed to be a main cause of decline of embryo quality. Then, L-carnitine plays important roles in reducing the membranous toxicity of free-fatty acids by forming acyl-carnitine and promoting b-oxidation, preventing cell damage. Recent research revealed that L-carnitine played important roles in vitro in oocyte growth, oocyte maturation and embryo development. However, such beneficial effects of L-carnitine in vivo have yet to be verified. The effect of oral L-carnitine supplementation on embryo quality and implantation potential was examined. A total of 214 patients were included in this study. They all previously received in vitro fertilization-embryo transfer (IVF-ET) and failed to conceive. Then they were administered L-carnitine for 82 days on average and underwent IVF-ET again. There were no significant differences in the total number of retrieved oocytes, and their maturation and fertilization rates between before and after L -carnitine administration. The quality of embryos on Days 3 and 5 after insemination was improved following L-carnitine administration (p<.05) in cycles after L-carnitine administration compared with previous cycles. Healthy neonates were born after IVF-ET following L-carnitine administration. Our data suggested that oral administration of L-carnitine to fertility patients improved the developmental competence of their oocytes after insemination. https://ndlsearch.ndl.go.jp/books/R100000039-I11378277 博士論文 Thu, 30 Oct 2025 01:05:06 +0900