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排卵・妊娠維持ほか各種産科婦人科学領域におけるG-CSFの動態に関する研究 / 牧野田, 知, 金沢医科大学

Tue, 29 Nov 2005 08:59:59 +0900

牧野田, 知, 金沢医科大学. 排卵・妊娠維持ほか各種産科婦人科学領域におけるG-CSFの動態に関する研究. 1998-1999

顆粒球コロニー刺激因子 : G-CSFの基礎と臨床 / 高久史麿編

Fri, 06 Mar 2026 10:03:02 +0900

高久史麿編. 顆粒球コロニー刺激因子 : G-CSFの基礎と臨床. 医薬ジャーナル, 1990; 1990.12. ISBN:4753212920

早産児の修正月齢満期の脳損傷と関連する臍帯動脈炎の最適な予測因子としての臍帯血顆粒球コロニー刺激因子濃度 / 楡井, 淳

Wed, 29 Oct 2025 02:57:14 +0900

楡井, 淳. 早産児の修正月齢満期の脳損傷と関連する臍帯動脈炎の最適な予測因子としての臍帯血顆粒球コロニー刺激因子濃度. 2024-03-25
Objective: The study aimed 1) to evaluate the association between the presence or absence of umbilical cord arteritis (UCA) and the cord blood cytokine levels, and 2) morbidity and mortality of preterm neonates; and 3) to identify predictive markers for UCA of preterm neonates. Study design: In this single-center retrospective observational cohort study, preterm neonates born at gestational age (GA) < 36 weeks were categorized pathologically according to the severity of intrauterine inflammation; those without UCA as Group 1, those with UCA as Group 2, and those without any intrauterine inflammation as Group 3 (control), and subgroup analyses classified by their GA were performed. We compared morbidity and mortality, and eight representative cytokine levels in cord blood samples between the groups. Subsequently, receiver operating characteristics (ROC) curves for UCA diagnosis for each cytokine were created, and values of areas under the curve (AUC) were calculated to determine the optimal predictive markers. Results: In total, 105 patients (36, 58, and 11 in Groups 1, 2, and 3, respectively) were included. Multivariate logistic analysis revealed that patients with UCA had higher incidence of brain injury (Odds Ratio [OR] = 8.53, P = 0.0049, 95% Confidence Interval [CI]: 1.91 – 38.0), at term equivalent age in the subgroup analysis with GA < 32 weeks. Although the median value of cord blood granulocyte colony-stimulating factor (G-CSF) was signifi-cantly higher in Group 2 than in Group 1 or 3, only the G-CSF level was found to be high in the subgroup analysis with GA < 32 weeks. For UCA diagnosis, the AUC values of G-CSF were the highest among eight cytokines including interleukin 6 (IL-6). These findings were similar in the subgroup analysis with GA < 32 weeks. Conclusions: Preterm neonates, especially born at GA < 32 week, had higher morbidity from brain injury in the group with UCA. The cord blood G-CSF level was highly accurate for predicting UCA and could thus be used as an optimal biomarker.

Granulocyte colony-stimulating factor potentiates all-trans retinoic acid-induced granulocytic differentiation in acute promyelocytic leukemia cell line HT93A / 内野,慶人

Thu, 30 Oct 2025 01:13:43 +0900

内野,慶人. Granulocyte colony-stimulating factor potentiates all-trans retinoic acid-induced granulocytic differentiation in acute promyelocytic leukemia cell line HT93A. 2017-11-13. DOI:10.15006/32665B7206; 10.15006/32665B7206

急性前骨髄性白血病細胞株HT93A においてG-CSF の併用はATRA 及び亜ヒ酸の分化誘導と亜ヒ酸の細胞内取り込みを増強させる / 入山, 規良

Thu, 30 Oct 2025 00:48:22 +0900

入山, 規良. 急性前骨髄性白血病細胞株HT93A においてG-CSF の併用はATRA 及び亜ヒ酸の分化誘導と亜ヒ酸の細胞内取り込みを増強させる. 2013-07-01. DOI:10.15006/32665B7022; 10.15006/32665B7022

早産児の修正月齢満期の脳損傷と関連する臍帯動脈炎の最適な予測因子としての臍帯血顆粒球コロニー刺激因子濃度 / 楡井, 淳

Tue, 22 Apr 2025 18:07:27 +0900

楡井, 淳. 早産児の修正月齢満期の脳損傷と関連する臍帯動脈炎の最適な予測因子としての臍帯血顆粒球コロニー刺激因子濃度