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卵巣摘出骨粗鬆症サルにおける顎骨・歯周組織病変の解析 : 画像解析システム開発へのアプローチ / 阪本真弥, 東北大学 [著]

Wed, 24 Nov 2004 23:03:09 +0900

阪本真弥, 東北大学 [著]. 卵巣摘出骨粗鬆症サルにおける顎骨・歯周組織病変の解析 : 画像解析システム開発へのアプローチ. [阪本真弥], 2001-2003; 2004.3

Effects of gonadal status and the estrogen milieu on hypothalamic oxytocin gene expression and serum oxytocin levels in female rats / 德井, 貴子ほか

Fri, 12 Jun 2026 12:39:50 +0900

The Roles of ROS Generation in RANKL-Induced Osteoclastogenesis : Suppressive Effects of Febuxostat / アシテル, モハナッドほか

Fri, 12 Jun 2026 12:33:05 +0900

The accumulation of brain water-free sodium is associated with ischemic damage independent of the blood pressure in female rats / 住吉, 学ほか

Fri, 12 Jun 2026 12:13:21 +0900

住吉, 学; キタザト, ケイコ; 八木, 謙次; 宮本, 健志; 倉敷, 佳孝; 松下, 展久; 木内, 智也; 桑山, 一行; 里見, 淳一郎; 永廣, 信治. The accumulation of brain water-free sodium is associated with ischemic damage independent of the blood pressure in female rats. Elsevier, 2015-05-07

Laparoscopic hysterectomy and oophorectomy : a practical manual and colour atlas / Jeffrey H. Phipps ; foreword by B. Victor Lewis ; illustrations by Peter Cox

Fri, 06 Mar 2026 10:03:02 +0900

Jeffrey H. Phipps ; foreword by B. Victor Lewis ; illustrations by Peter Cox. Laparoscopic hysterectomy and oophorectomy : a practical manual and colour atlas. Churchill Livingstone, 1993. ISBN:0443049297

Therapieergebnisse bei Mammakarzinom nach Androgenbehandlung und Ovarektomie / von Armin Schöll

Fri, 09 Jan 2026 11:13:45 +0900

von Armin Schöll. Therapieergebnisse bei Mammakarzinom nach Androgenbehandlung und Ovarektomie. G. Thieme, 1975. ISBN:3131230010

Bericht über 235 in der Jenaischen Frauenklinik in den Jahren 1888-1898 ausgeführte Ovariotomien / vorgelegt von Max Seyerlen

Fri, 09 Jan 2026 11:13:45 +0900

vorgelegt von Max Seyerlen. Bericht über 235 in der Jenaischen Frauenklinik in den Jahren 1888-1898 ausgeführte Ovariotomien. G. Neuenhahn, 1900

Effects of gonadal status and the estrogen milieu on hypothalamic oxytocin gene expression and serum oxytocin levels in female rats 133 / 德井, 貴子ほか

Sat, 04 Jul 2026 21:46:24 +0900

德井, 貴子; 河北, 貴子; ヤナギハラ, リエ; 鎌田, 周平; 湊, 沙希; 武田, 明日香; 今泉, 絢貴; 山本, 由理; 吉田, 加奈子; 加藤, 剛志; 苛原, 稔; 岩佐, 武. Effects of gonadal status and the estrogen milieu on hypothalamic oxytocin gene expression and serum oxytocin levels in female rats 133. Elsevier, 2021-06-08; 133
Oxytocin (OT) and its receptor (OTR) play various roles in the central and peripheral regulation of appetite and body weight. Previously, we have shown that the administration of OT markedly decreased appetite and body weight gain in ovariectomized (OVX) obese rats. In addition, recent studies have shown that the endogenous OT system is also affected by endogenous or exogenous estrogen. In this study, we showed that ovariectomy decreased rats' hypothalamic OT/OTR mRNA and serum OT levels, but did not affect their visceral fat OTR mRNA levels. The chronic administration of estradiol (E2) abrogated these ovariectomy-induced changes; i.e., it increased the rats' hypothalamic OT/OTR mRNA and serum OT levels, and may be associated with reductions in food intake and body weight gain. In addition, acute E2 administration increased the rats' hypothalamic OTR mRNA and serum OT levels, but did not affect their hypothalamic OT mRNA levels. Taken together, these results suggest that endogenous OT and/or OTR expression might be positively regulated by E2 and that the suppressive effects of E2 on appetite and body weight gain might be mediated, at least in part, by the OT system. Thus, we consider that OT might be a target hormone to pursue subsequent interventions of menopause for menopause-induced metabolic disorders.

The Roles of ROS Generation in RANKL-Induced Osteoclastogenesis : Suppressive Effects of Febuxostat 12 4 / アシテル, モハナッドほか

Sat, 04 Jul 2026 21:47:25 +0900

アシテル, モハナッド; 天眞, 寛文; 寺町, 順平; Bat-Erdene, Ariunzaya; 日浅, 雅博; オダ, アスカ; 谷本, 幸多朗; 清水, 宗; ヒガ, ヨシキ; 原田, 武志; 大浦, 雅博; 曽我部, 公子; 中村, 信元; 藤井, 志朗; 住谷, 龍平; 三木, 浩和; ウダカ, ケンゴ; タカハシ, マミコ; 賀川, 久美子; 遠藤, 逸朗; 田中, 栄二; 松本, 俊夫; 安倍, 正博. The Roles of ROS Generation in RANKL-Induced Osteoclastogenesis : Suppressive Effects of Febuxostat 12 4. MDPI, 2020-04-09; 12 4
Receptor activator of NF-κB ligand (RANKL), a critical mediator of osteoclastogenesis, is upregulated in multiple myeloma (MM). The xanthine oxidase inhibitor febuxostat, clinically used for prevention of tumor lysis syndrome, has been demonstrated to effectively inhibit not only the generation of uric acid but also the formation of reactive oxygen species (ROS). ROS has been demonstrated to mediate RANKL-mediated osteoclastogenesis. In the present study, we therefore explored the role of cancer-treatment-induced ROS in RANKL-mediated osteoclastogenesis and the suppressive effects of febuxostat on ROS generation and osteoclastogenesis. RANKL dose-dependently induced ROS production in RAW264.7 preosteoclastic cells; however, febuxostat inhibited the RANKL-induced ROS production and osteoclast (OC) formation. Interestingly, doxorubicin (Dox) further enhanced RANKL-induced osteoclastogenesis through upregulation of ROS production, which was mostly abolished by addition of febuxostat. Febuxostat also inhibited osteoclastogenesis enhanced in cocultures of bone marrow cells with MM cells. Importantly, febuxostat rather suppressed MM cell viability and did not compromise Dox’s anti-MM activity. In addition, febuxostat was able to alleviate pathological osteoclastic activity and bone loss in ovariectomized mice. Collectively, these results suggest that excessive ROS production by aberrant RANKL overexpression and/or anticancer treatment disadvantageously impacts bone, and that febuxostat can prevent the ROS-mediated osteoclastic bone damage.

拘束性ストレスと卵巣摘出による口腔内灼熱症候群モデルマウス作製とピオグリタゾン大槽内投与の効果 / 米本,真実子

Thu, 09 Jul 2026 22:15:03 +0900

米本,真実子. 拘束性ストレスと卵巣摘出による口腔内灼熱症候群モデルマウス作製とピオグリタゾン大槽内投与の効果. 2026-03-25. DOI:10.15006/0002004495; 10.15006/0002004495

バーニングマウス症候群の病態に関する内分泌学的検討 / 関根,尚彦

Mon, 03 Jun 2024 18:46:19 +0900

関根,尚彦. バーニングマウス症候群の病態に関する内分泌学的検討. DOI:10.15006/32665A5631