ナローバンドUVBを発光するLEDを用いたアレルギー性鼻炎の光治療装置の開発(武田憲昭教授退任記念総説集)

• 資料種別: 記事
• タイトル: ナローバンドUVBを発光するLEDを用いたアレルギー性鼻炎の光治療装置の開発
• 著者・編者: 神村 盛一郎; 北村 嘉章; 藤井 達也; 福井 裕行; 水口 博之; 武田 憲昭
• シリーズタイトル: 武田憲昭教授退任記念総説集
• 著者標目: 神村 盛一郎; 北村 嘉章; 藤井 達也; 福井 裕行; 水口 博之; 武田 憲昭
• 並列タイトル等: Development of a Phototherapy Device for Allergic Rhinitis Using LEDs Emitting Narrowband UVB
• タイトル（掲載誌）: 耳鼻咽喉科臨床. 補冊 = Practica oto-rhino-laryngologica. Suppl / 耳鼻咽喉科臨床学会 編
• 巻号年月日等（掲載誌）: (158):2022.2
• 掲載号: 158
• 掲載ページ: 20-28
• 掲載年月日（W3CDTF）: 2022-02
• ISSN（掲載誌）: 0912-1870
• ISSN-L（掲載誌）: 0912-1870
• 出版事項（掲載誌）: 京都 : 耳鼻咽喉科臨床学会
• 出版地（国名コード）: JP
• 本文の言語コード: jpn
• 件名標目: allergic rhinitis; apoptosis; histamine H₁ receptor; narrow-band ultraviolet B; phototherapy
• NDLC: ZS43
• 対象利用者: 一般
• 所蔵機関: 国立国会図書館
• 請求記号: Z19-1772
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館雑誌記事索引; https://ndlsearch.ndl.go.jp
• 書誌ID（NDLBibID）: 031985319; http://id.ndl.go.jp/bib/031985319
• 整理区分コード: 632

• 要約等: <p>Narrowband ultraviolet B (NB-UVB) phototherapy has been used clinically for the treatment of atopic dermatitis (AD). Therefore, NB-UVB phototherapy could also be effective for the treatment of allergic rhinitis (AR), because AR is also a Th2-dominant disease like AD. Recently, light-emitting diodes (LEDs) that emit selective UVB spectra at a wavelength of 310 nm (NB-UVB) have been developed, that are small enough for intranasal phototherapy. In order to develop NB-UVB phototherapy for AR, we first examined the effects of NB-UVB irradiation on the <i>H1R</i> gene expression in HeLa cells. We demonstrated that low-dose NB-UVB irradiation reversibly suppressed PMA-induced upregulation of H1R mRNA in a wavelength-specific and dose-dependent manner, without inducing apoptosis of the HeLa cells. We then conducted an <i>in vivo</i> study using toluene 2,4-diisocyanate (TDI)-sensitized rats, an animal model of AR. We demonstrated that intranasal NB-UVB pre-irradiation suppressed TDI-induced upregulation of H1R mRNA in the nasal mucosa in a dose-dependent manner, without induction of DNA damage, causing suppression of the TDI-induced nasal symptoms in this animal model of AR. These findings suggest that low-dose NB-UVB phototherapy could be effectively and safely applied for the treatment of AR. Finally, we have developed a prototype of an NB-UVB phototherapy device and demonstrated its safety in phase I and early phase II clinical trials.</p>
• DOI: 10.5631/jibirinsuppl.158.20
• オンライン閲覧公開範囲: インターネット公開
• 連携機関・データベース: 科学技術振興機構 : J-STAGE; http://www.jstage.jst.go.jp

• 要約等: <p>Narrowband ultraviolet B (NB-UVB) phototherapy has been used clinically for the treatment of atopic dermatitis (AD). Therefore, NB-UVB phototherapy could also be effective for the treatment of allergic rhinitis (AR), because AR is also a Th2-dominant disease like AD. Recently, light-emitting diodes (LEDs) that emit selective UVB spectra at a wavelength of 310 nm (NB-UVB) have been developed, that are small enough for intranasal phototherapy. In order to develop NB-UVB phototherapy for AR, we first examined the effects of NB-UVB irradiation on the <i>H1R</i> gene expression in HeLa cells. We demonstrated that low-dose NB-UVB irradiation reversibly suppressed PMA-induced upregulation of H1R mRNA in a wavelength-specific and dose-dependent manner, without inducing apoptosis of the HeLa cells. We then conducted an <i>in vivo</i> study using toluene 2,4-diisocyanate (TDI)-sensitized rats, an animal model of AR. We demonstrated that intranasal NB-UVB pre-irradiation suppressed TDI-induced upregulation of H1R mRNA in the nasal mucosa in a dose-dependent manner, without induction of DNA damage, causing suppression of the TDI-induced nasal symptoms in this animal model of AR. These findings suggest that low-dose NB-UVB phototherapy could be effectively and safely applied for the treatment of AR. Finally, we have developed a prototype of an NB-UVB phototherapy device and demonstrated its safety in phase I and early phase II clinical trials.</p>
• DOI: 10.5631/jibirinsuppl.158.20; https://doi.org/10.5631/jibirinsuppl.158.20
• 関連情報（URI）: http://id.ndl.go.jp/bib/031985319; https://ndlsearch.ndl.go.jp/books/R000000004-I031985319; https://www.jstage.jst.go.jp/article/jibirinsuppl/158/0/158_20/_pdf; https://search.jamas.or.jp/link/ui/2022109247
• 参照: Effects of irradiation with narrowband-ultraviolet B on up-regulation of histamine H1 receptor mRNA and induction of apoptosis in HeLa cells and nasal mucosa of rats; https://cir.nii.ac.jp/crid/1360004232315037312; Irradiation with narrowband-ultraviolet B suppresses phorbol ester-induced up-regulation of H₁receptor mRNA in HeLa cells; https://cir.nii.ac.jp/crid/1360004239194284928; Preseasonal prophylactic treatment with antihistamines suppresses nasal symptoms and expression of histamine H1 receptor mRNA in the nasal mucosa of patients with pollinosis; https://cir.nii.ac.jp/crid/1360285712383165312; Transcriptional up‐regulation of histamine receptor‐1 in epithelial, mucus and inflammatory cells in perennial allergic rhinitis; https://cir.nii.ac.jp/crid/1360292618594215296; Reversal of atopic dermatitis with narrow-band UVB phototherapy and biomarkers for therapeutic response; https://cir.nii.ac.jp/crid/1360292620644559104; Endonasal phototherapy with Rhinolight^®for the treatment of allergic rhinitis; https://cir.nii.ac.jp/crid/1360574093902491520; Increased expression of histamine H₁ receptor mRNA in allergic rhinitis; https://cir.nii.ac.jp/crid/1360574094986721536; PMA-induced dissociation of Ku86 from the promoter causes transcriptional up-regulation of histamine H1 receptor; https://cir.nii.ac.jp/crid/1360848658454912000; Effects of narrow‐band <scp>UVB</scp> on nasal symptom and upregulation of histamine <scp>H₁</scp> receptor <scp>mRNA</scp> in allergic rhinitis model rats; https://cir.nii.ac.jp/crid/1360853567450534784; PUVA treatment of the nasal cavity improves the clinical symptoms of allergic rhinitis and inhibits the immediate-type hypersensitivity reaction in the skin; https://cir.nii.ac.jp/crid/1361418520025821696; Rhinophototherapy: A new therapeutic tool for the management of allergic rhinitis; https://cir.nii.ac.jp/crid/1361418520464547456; Narrow-Band Red Light Phototherapy in Perennial Allergic Rhinitis and Nasal Polyposis; https://cir.nii.ac.jp/crid/1361699994804611456; Ultraviolet light phototherapy for allergic rhinitis; https://cir.nii.ac.jp/crid/1362262945312837632; Ultraviolet B 308-nm excimer laser treatment of psoriasis: a new phototherapeutic approach; https://cir.nii.ac.jp/crid/1362544418555507456; Effects of antihistamine on up-regulation of histamine H1 receptor mRNA in the nasal mucosa of patients with pollinosis induced by controlled cedar pollen challenge in an environmental exposure unit; https://cir.nii.ac.jp/crid/1362825893503413760
• 連携機関・データベース: 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/
• 提供元機関・データベース: Japan Link Center; https://japanlinkcenter.org/top; 雑誌記事索引データベース; https://ndlsearch.ndl.go.jp; Crossref; https://www.crossref.org; CiNii Articles
• 書誌ID（NDLBibID）: 031985319; http://id.ndl.go.jp/bib/031985319
• NII論文ID: 40022823278