発育期における長期間の自発走運動とカロリー制限が雌ラット骨格筋の細胞内シグナル伝達に及ぼす影響
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- 資料種別
- 記事
- 著者・編者
- 小川 咲桜長谷川 雄彦吉原 利典
- 並列タイトル等
- Effects of long-term voluntary running exercise and caloric restriction during development on intracellular signaling in female rat skeletal muscles
- タイトル（掲載誌）
- 体力科学 = The Japanese journal of physical fitness and sports medicine
- 巻号年月日等（掲載誌）
- 74(3):2025.6
- 掲載巻
- 74
- 掲載号
- 3
- 掲載ページ
- 155-170
- 掲載年月日（W3CDTF）
- 2025-06
- ISSN（掲載誌）
- 0039-906X
- ISSN-L（掲載誌）
- 0039-906X
- 出版事項（掲載誌）
- 東京 : 日本体力医学会
- 出版地（国名コード）
- JP
- 本文の言語コード
- jpn
- 件名標目
- NDLC
- 対象利用者
- 一般
- 所蔵機関
- 国立国会図書館
- 請求記号
- Z7-301
- 連携機関・データベース
- 国立国会図書館 : 国立国会図書館雑誌記事索引
- 書誌ID（NDLBibID）
- 034201626
- 整理区分コード
- 632
- 要約等
- <p>In this study, we aimed to investigate the effects of long-term voluntary running exercise and caloric restriction during development on the skeletal muscle mass and intracellular signaling in female rats. Four-week-old female Wistar rats (n = 23) were randomly divided into the sedentary (SED) and voluntary running exercise (EX) groups, and then acclimated to a new environment. At 5 weeks of age, the rats in both groups were further divided into the ad libitum (AD+SED or AD+EX, n = 6) and calorie-restricted (CR+SED or CR+EX, n = 5-6) groups. EX group underwent 12 weeks of voluntary running exercise. CR group was only fed 70% of the food fed to the AD + SED group. After 12 weeks of intervention, soleus and plantaris muscles were removed, and the levels of intracellular signal transduction proteins involved in protein synthesis and degradation were measured by Western blotting. Significant diet × condition interactions were observed in the body, soleus muscle, and plantaris muscle weights. Specifically, plantaris muscle weight in the CR + EX group was significantly lower than that in the other groups; however, their soleus muscle weight was similar to that in the CR + SED group. In the plantaris muscles, significant diet × condition interactions were observed in the phosphorylation levels of 4E-binding protein 1, UNC-51-like autophagy-activating kinase-1, and light chain 3-II/I. Moreover, these factors were significantly altered in the CR + EX group than in the other groups. Notably, no significant interactions were observed in the soleus muscles. Our data suggest that long-term voluntary running exercise and caloric restriction exacerbate skeletal muscle loss, possibly mediated by muscle type-specific intracellular signaling mechanisms involved in protein synthesis and degradation.</p>
- DOI
- 10.7600/jspfsm.74.155
- オンライン閲覧公開範囲
- インターネット公開
- 連携機関・データベース
- 科学技術振興機構 : J-STAGE
- 要約等
- <p>In this study, we aimed to investigate the effects of long-term voluntary running exercise and caloric restriction during development on the skeletal muscle mass and intracellular signaling in female rats. Four-week-old female Wistar rats (n = 23) were randomly divided into the sedentary (SED) and voluntary running exercise (EX) groups, and then acclimated to a new environment. At 5 weeks of age, the rats in both groups were further divided into the ad libitum (AD+SED or AD+EX, n = 6) and calorie-restricted (CR+SED or CR+EX, n = 5-6) groups. EX group underwent 12 weeks of voluntary running exercise. CR group was only fed 70% of the food fed to the AD + SED group. After 12 weeks of intervention, soleus and plantaris muscles were removed, and the levels of intracellular signal transduction proteins involved in protein synthesis and degradation were measured by Western blotting. Significant diet × condition interactions were observed in the body, soleus muscle, and plantaris muscle weights. Specifically, plantaris muscle weight in the CR + EX group was significantly lower than that in the other groups; however, their soleus muscle weight was similar to that in the CR + SED group. In the plantaris muscles, significant diet × condition interactions were observed in the phosphorylation levels of 4E-binding protein 1, UNC-51-like autophagy-activating kinase-1, and light chain 3-II/I. Moreover, these factors were significantly altered in the CR + EX group than in the other groups. Notably, no significant interactions were observed in the soleus muscles. Our data suggest that long-term voluntary running exercise and caloric restriction exacerbate skeletal muscle loss, possibly mediated by muscle type-specific intracellular signaling mechanisms involved in protein synthesis and degradation.</p>
- DOI
- 10.7600/jspfsm.74.155
- 関連情報（URI）
- 参照
- The Interaction of Voluntary Running Exercise and Food Restriction Induces Low Bone Strength and Low Bone Mineral Density in Young Female RatsThe Preventive Effect of Calcium Supplementation on Weak Bones Caused by the Interaction of Exercise and Food Restriction in Young Female Rats During the Period from Acquiring Bone Mass to Maintaining Bone MassCaloric Restriction and Aging: Studies in Mice and Monkeys4E-BP1 and S6K1: translational integration sites for nutritional and hormonal information in musclemTOR at the nexus of nutrition, growth, ageing and diseaseLow energy availability: history, definition and evidence of its endocrine, metabolic and physiological effects in prospective studies in females and malesWeight Loss Strategies and the Risk of Skeletal Muscle Mass LossLow energy availability reduces myofibrillar and sarcoplasmic muscle protein synthesis in trained femalesA novel nutritional supplement prevents muscle loss and accelerates muscle mass recovery in caloric-restricted miceEffects of high‐resistance wheel running on hallmarks of endurance and resistance training adaptations in miceProgression Models in Resistance Training for Healthy AdultsEndurance exercise-induced histone methylation modification involved in skeletal muscle fiber type transition and mitochondrial biogenesisModulation of autophagy signaling with resistance exercise and protein ingestion following short-term energy deficitEffects of Rapid or Slow Body Weight Reduction on Intramuscular Protein Degradation Pathways During Equivalent Weight Loss on RatsThe Effects of Endurance, Strength, and Power Training on Muscle Fiber Type ShiftingAdequate Energy Intake Prevents Low Bone Mass Under Exercise and Low Intake of Nutrients in Young Female Rats2023 International Olympic Committee’s (IOC) consensus statement on Relative Energy Deficiency in Sport (REDs)Calorie Restriction-Regulated Molecular Pathways and Its Impact on Various Age Groups: An OverviewFemale Athlete Triad and Male Athlete Triad Syndrome Induced by Low Energy Availability: An Animal ModelEndocrine Effects of Relative Energy Deficiency in SportAkt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo2014 Female Athlete Triad Coalition Consensus Statement on Treatment and Return to Play of the Female Athlete TriadEnergy state and myosin heavy chain isoforms in single fibres of normal and transforming rabbit musclesStaging of the estrous cycle and induction of estrus in experimental rodents: an updatePerforming Vaginal Lavage, Crystal Violet Staining, and Vaginal Cytological Evaluation for Mouse Estrous Cycle Staging IdentificationProtein Degradation by the Ubiquitin–Proteasome Pathway in Normal and Disease StatesReduced resting skeletal muscle protein synthesis is rescued by resistance exercise and protein ingestion following short-term energy deficitRegulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networksThe effect of fasting or calorie restriction on autophagy induction: A review of the literatureLong-Term Sensitivity of Uterus and Hypothalamus/Pituitary Axis to 17β-Estradiol Is Higher Than That of Bone in RatsThe Female Athlete TriadCalorie restriction in humans inhibits the <scp>PI</scp>3<scp>K</scp>/<scp>AKT</scp> pathway and induces a younger transcription profileEffects of food deprivation on protein synthesis and degradation in rat skeletal musclesCaloric restriction optimizes the proteasome pathway with aging in rat plantaris muscle: implications for sarcopeniaAutophagic flux and oxidative capacity of skeletal muscles during acute starvationA chronic increase in physical activity inhibits fed-state mTOR/S6K1 signaling and reduces IRS-1 serine phosphorylation in rat skeletal muscleMechanisms for fiber-type specificity of skeletal muscle atrophyMuscle Glycogen Content during Endurance Training under Low Energy AvailabilityCalorie restriction in humans: An updateModified activity-stress paradigm in an animal model of the female athlete triadRegulatory mechanisms of muscle fiber types and their possible interactions with external nutritional stimuliEffect of Food Restriction and Intense Physical Training on Estrous Cyclicity and Plasma Leptin Concentrations in Rats
- 連携機関・データベース
- 国立情報学研究所 : CiNii Research
- 提供元機関・データベース
- Japan Link Center雑誌記事索引データベースCrossref
- 書誌ID（NDLBibID）
- 034201626