Lyotropic Liquid Crystals Prepared with Biocompatible Ionic Liquids for Improving Transdermal Permeation

• 資料種別: 記事
• タイトル: Lyotropic Liquid Crystals Prepared with Biocompatible Ionic Liquids for Improving Transdermal Permeation
• 著者・編者: Koki Hara; Masahiro Goto
• 著者標目: Koki Hara; Masahiro Goto
• タイトル（掲載誌）: 膜 = Membrane / 膜編集委員会 編
• 巻号年月日等（掲載誌）: 50(5)=299:2025.9
• 掲載巻: 50
• 掲載号: 5
• 掲載通号: 299
• 掲載ページ: 229-236
• 掲載年月日（W3CDTF）: 2025-09
• ISSN（掲載誌）: 0385-1036
• ISSN-L（掲載誌）: 0385-1036
• 出版事項（掲載誌）: 東京 : 日本膜学会
• 出版地（国名コード）: JP
• 本文の言語コード: eng
• 件名標目: liquid crystals; favipiravir; ionic liquids; transdermal drug delivery
• NDLC: ZR2
• 対象利用者: 一般
• 所蔵機関: 国立国会図書館
• 請求記号: Z18-1127
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館雑誌記事索引; https://ndlsearch.ndl.go.jp
• 書誌ID（NDLBibID）: 034369910; http://id.ndl.go.jp/bib/034369910
• 整理区分コード: 632

• 要約等: Lyotropic liquid crystals (LLCs) have been attracting attention as new transdermal drug delivery carriers because of their high stability compared with that of other liquid carriers, such as emulsions, micelles, and liposomes. However, the transdermal delivery performance of LLCs is not satisfactory because their high viscosity often reduces the permeation rate of the drugs. In the present study, to improve the performance of LLCs as a drug delivery carrier, we have developed an ionic liquid crystal (ILC) formulation by adding an ionic liquid (IL) component as a mesogen, which can enhance transdermal permeation. A biocompatible ionic liquid IL[Cho][Ole], composed of choline and oleic acid, was synthesized for pharmaceutical applications. The ILC formulations loaded with 1 wt% of favipiravir (FAV), which had potential as a therapeutic agent for coronavirus infections, showed excellent stability. In vitro drug permeation experiments using mouse skin indicated that the ILCs enhanced the permeability of FAV. In particular, FAV–ILC–70 (IL[Cho][Ole] : water = 7 : 3 (w/w)), which has a gyroid structure, significantly improved the transdermal delivery of FAV by fluidizing the stratum corneum lipids. These results suggest that liquid crystalline formulations with biocompatible ILs are promising new transdermal drug delivery carriers.
• DOI: 10.5360/membrane.50.229
• オンライン閲覧公開範囲: インターネット公開
• 連携機関・データベース: 科学技術振興機構 : J-STAGE; http://www.jstage.jst.go.jp

• 要約等: Lyotropic liquid crystals (LLCs) have been attracting attention as new transdermal drug delivery carriers because of their high stability compared with that of other liquid carriers, such as emulsions, micelles, and liposomes. However, the transdermal delivery performance of LLCs is not satisfactory because their high viscosity often reduces the permeation rate of the drugs. In the present study, to improve the performance of LLCs as a drug delivery carrier, we have developed an ionic liquid crystal (ILC) formulation by adding an ionic liquid (IL) component as a mesogen, which can enhance transdermal permeation. A biocompatible ionic liquid IL[Cho][Ole], composed of choline and oleic acid, was synthesized for pharmaceutical applications. The ILC formulations loaded with 1 wt% of favipiravir (FAV), which had potential as a therapeutic agent for coronavirus infections, showed excellent stability. In vitro drug permeation experiments using mouse skin indicated that the ILCs enhanced the permeability of FAV. In particular, FAV–ILC–70 (IL[Cho][Ole] : water = 7 : 3 (w/w)), which has a gyroid structure, significantly improved the transdermal delivery of FAV by fluidizing the stratum corneum lipids. These results suggest that liquid crystalline formulations with biocompatible ILs are promising new transdermal drug delivery carriers.
• DOI: 10.5360/membrane.50.229; https://doi.org/10.5360/membrane.50.229
• 関連情報（URI）: http://id.ndl.go.jp/bib/034369910; https://ndlsearch.ndl.go.jp/books/R000000004-I034369910; https://www.jstage.jst.go.jp/article/membrane/50/5/50_229/_pdf; https://search.jamas.or.jp/link/ui/2026089997
• 連携機関・データベース: 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/
• 提供元機関・データベース: Japan Link Center; https://japanlinkcenter.org/top; 雑誌記事索引データベース; https://ndlsearch.ndl.go.jp; Crossref; https://www.crossref.org
• 書誌ID（NDLBibID）: 034369910; http://id.ndl.go.jp/bib/034369910